{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T15:47:46Z","timestamp":1782920866409,"version":"3.54.5"},"reference-count":30,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:00:00Z","timestamp":1781136000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100031665","name":"Medical Research Center, Hamad Medical Corporation","doi-asserted-by":"publisher","award":["(MRC-01-20-056)."],"award-info":[{"award-number":["(MRC-01-20-056)."]}],"id":[{"id":"10.13039\/100031665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder associated with considerable morbidity and mortality, particularly due to frequent hospitalisations. This study aimed to describe the causes, clinical course, and outcomes of hospitalisations among patients with SLE in a multinational cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective cohort included adults (aged \u226518 years) with SLE hospitalised at Hamad General Hospital, Qatar, between June 2016 and August 2020. Each admission was considered separately. Data included demographics, clinical features, SLE Disease Activity Index (SLEDAI), serological markers, complications, treatments, and prognoses. Predictors of intensive care unit (ICU) admission were evaluated using univariable and multivariable logistic regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There were 281 admissions among 153 patients. Most patients (87%)\u2002were female, with a median age of 34 years (IQR: 26\u201344). The principal causes of admission were lupus flares, haematologic (38%), renal (28%), and articular (20%), followed by infection (20%). The median hospital stay was 7 days (IQR: 4\u201312). Re-admission occurred in 51% of the patients, and 17% of the admissions required ICU care. ICU admission was associated with a longer hospital stay (median 16 vs 6 days,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.001) and higher mortality (11% vs 0%,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.001). Factors predicting ICU admission were a higher SLEDAI score (odds ratio (OR) 1.14, 95% confidence interval (CI)1.07\u20131.21,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.001), sepsis (OR 4.91, 95% CI 2.02\u201311.89,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.001), and cardiac involvement (OR 7.57, 95% CI 1.74\u201332.93,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.007).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this multinational cohort, SLE flares and infections were the leading causes of hospitalisation. Sepsis, comorbid conditions, and high disease activity are associated with adverse outcomes. Optimising disease control, preventing infection, and managing comorbidities are essential to improve hospitalisation outcomes and reduce mortality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09612033261458573","type":"journal-article","created":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T07:02:26Z","timestamp":1781161346000},"page":"983-991","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Outcomes of systemic lupus erythematosus hospitalisations in Qatar: Insights from a multinational tertiary centre experience"],"prefix":"10.1177","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9470-1569","authenticated-orcid":false,"given":"Miral H.","family":"Gharib","sequence":"first","affiliation":[{"name":"Division of Rheumatology, Department of Medicine, Hamad Medical Corporation, Doha, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karima","family":"Becetti","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Medicine, Hamad Medical Corporation, Doha, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hana J.","family":"Abukhadijah","sequence":"additional","affiliation":[{"name":"Clinical Trials Unit, Medical Care and Research Center, Hamad Medical Corporation, Doha, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiaz","family":"Alam","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Medicine, Hamad Medical Corporation, Doha, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aishwariya","family":"Padmakumari","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Medicine, Hamad Medical Corporation, Doha, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"AL-Kahlout","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Medicine, Hamad Medical Corporation, Doha, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rawan","family":"Saleh","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Medicine, Hamad Medical Corporation, Doha, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Bilal","family":"Jamshaid","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Medicine, Hamad Medical Corporation, Doha, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7942-4831","authenticated-orcid":false,"given":"Samar","family":"AL-Emadi","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Medicine, Hamad Medical Corporation, Doha, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,6,11]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-021-00668-1"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.39"},{"key":"e_1_3_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2005.11.034"},{"key":"e_1_3_7_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-022-02878-8"},{"key":"e_1_3_7_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/acr2.11195"},{"key":"e_1_3_7_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/0961203313505689"},{"key":"e_1_3_7_8_2","first-page":"1559","article-title":"Incidence of and risk factors for hospitalizations in systemic lupus erythematosus: a prospective study of the Hopkins lupus cohort","volume":"19","author":"Petri M","year":"1992","unstructured":"Petri M, Genovese M. Incidence of and risk factors for hospitalizations in systemic lupus erythematosus: a prospective study of the Hopkins lupus cohort. J Rheumatol 1992; 19: 1559\u20131565, PMID: 1464868.","journal-title":"J Rheumatol"},{"key":"e_1_3_7_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199905)42:5<891::AID-ANR7>3.0.CO;2-B"},{"key":"e_1_3_7_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kes391"},{"key":"e_1_3_7_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-022-06251-7"},{"key":"e_1_3_7_12_2","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.919381"},{"key":"e_1_3_7_13_2","doi-asserted-by":"publisher","DOI":"10.1177\/09612033241283551"},{"key":"e_1_3_7_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keac610"},{"key":"e_1_3_7_15_2","doi-asserted-by":"publisher","DOI":"10.1186\/s43166-021-00102-0"},{"issue":"20211018","key":"e_1_3_7_16_2","first-page":"e18858","article-title":"Causes of hospitalization for systemic lupus erythematosus in Saudi Arabia compared with the global setting: a retrospective single-center observational study","volume":"13","author":"Alhassan N","year":"2021","unstructured":"Alhassan N, Almetri T, Abualsoud S, et al. Causes of hospitalization for systemic lupus erythematosus in Saudi Arabia compared with the global setting: a retrospective single-center observational study. 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