{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T12:26:34Z","timestamp":1787660794101,"version":"build-2736575974"},"reference-count":18,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Our aim was to evaluate clinical and renal histopathological variables associated with the diagnosis of Systemic Lupus Erythematosus (SLE) in a South American cohort with Full-House (FH) glomerulonephritis (GN) in order to distinguish it from other causes of FHGN.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Observational retrospective study. Kidney biopsies performed in our hospital between 2000 and 2019 were reviewed, identifying those with a FH pattern. Clinical, analytical, and histopathological data were collected. Patients were classified as SLE with Lupus - FHGN (if they met ACR 1997 and\/or SLICC 2012 and\/or ACR-EULAR 2019 SLE criteria) and as non-Lupus FH GN (idiopathic or secondary). Descriptive statistics, univariate and multivariate logistic regression analysis were performed to identify factors associated with Lupus- FHGN, and Kaplan-Meier survival curves were used to compare renal survival between both groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      181 patients with FHGN were included, 124 women (68.5%), with a mean age of 41.1\u00a0years (SD 16.0) and a median post-biopsy follow-up time of 2.9\u00a0years (IQR 0.4-6.8\u00a0years). 116 patients (64.1%) met SLE criteria (103 with extrarenal manifestations and 13 with renal-limited lupus), 52 patients presented identifiable secondary causes of FHGN and 13 remained idiopathic FHGN. Renal biopsies in Lupus - FHGN presented more frequently 3 or 4 crosses of IgG, C3 and C1q deposits (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.001) and had less moderate\/severe involvement of the tubulointerstitial compartment (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.001), when compared with non-Lupus FHGN. In the multivariate analysis, the factors that remained associated with Lupus - FHGN were: female sex, younger age, positive ANA, anti-DNA, and 3 or 4 crosses of C1q deposits. Lupus - FHGN showed a protective effect for the development of End-Stage Renal Disease (ESRD) in the univariate analysis (HR 0.34, 95% CI 0.13-0.89) but this association was not significant in the multivariate analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this South American cohort, 35.9% of FHGN were not associated with SLE diagnosis. Female sex, younger age, positive ANA or anti-DNA antibodies and marked C1q deposits at renal biopsy were associated with SLE diagnosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09612033261463575","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T12:18:00Z","timestamp":1782217080000},"page":"1058-1065","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical and histopathological predictors of systemic lupus erythematosus in a South American cohort of patients with full-house glomerulonephritis"],"prefix":"10.1177","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3860-3865","authenticated-orcid":false,"given":"Romina","family":"Tanten Zabaleta","sequence":"first","affiliation":[{"name":"Hospital Italiano de Buenos Aires"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estefania","family":"Espejo","sequence":"additional","affiliation":[{"name":"Hospital Italiano de Buenos Aires"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Scaglioni","sequence":"additional","affiliation":[{"name":"Hospital Italiano de Buenos Aires"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Christiansen","sequence":"additional","affiliation":[{"name":"Hospital Italiano de Buenos Aires"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Griselda","family":"Bratti","sequence":"additional","affiliation":[{"name":"Hospital Italiano de Buenos Aires"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Federico","family":"Varela","sequence":"additional","affiliation":[{"name":"Hospital Italiano de Buenos Aires"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier E.","family":"Rosa","sequence":"additional","affiliation":[{"name":"Hospital Italiano de Buenos Aires"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique R.","family":"Soriano","sequence":"additional","affiliation":[{"name":"Hospital Italiano de Buenos Aires"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo","family":"Greloni","sequence":"additional","affiliation":[{"name":"Hospital Italiano de Buenos Aires"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0542-8001","authenticated-orcid":false,"given":"Marina","family":"Scolnik","sequence":"additional","affiliation":[{"name":"Hospital Italiano de Buenos Aires"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,6,23]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/lupus-2014-000021"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2018-213512"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.05780616"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2017.11.023"},{"issue":"14","key":"e_1_3_6_6_2","first-page":"e82","article-title":"Value of repeat biopsy in lupus nephritis flares","volume":"93","author":"Greloni G","year":"2014","unstructured":"Greloni G, Scolnik M, Marin J, et al. Value of repeat biopsy in lupus nephritis flares. Medicine (Baltim) 2014; 93(14): e82.","journal-title":"Medicine (Baltim)"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfx020"},{"issue":"1","key":"e_1_3_6_8_2","first-page":"1","article-title":"KDIGO 2012 Clinical Practice Guideline for the evaluation and management of chronic kidney disease","volume":"3","author":"Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group","year":"2013","unstructured":"Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group. KDIGO 2012 Clinical Practice Guideline for the evaluation and management of chronic kidney disease. Kidney Int Suppl 2013; 3(1): 1\u2013150.","journal-title":"Kidney Int Suppl"},{"key":"e_1_3_6_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780400928"},{"key":"e_1_3_6_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.34473"},{"key":"e_1_3_6_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2018-214819"},{"key":"e_1_3_6_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/78.1.29"},{"key":"e_1_3_6_13_2","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.01570219"},{"key":"e_1_3_6_14_2","doi-asserted-by":"publisher","DOI":"10.3109\/0886022X.2010.510614"},{"issue":"1","key":"e_1_3_6_15_2","first-page":"37","article-title":"Idiopathic nonlupus full-house nephropathy: clinicopathological presentation and comparison with lupus full-house nephropathy","volume":"33","author":"Mahanta P","year":"2022","unstructured":"Mahanta P, Ahmed S, Paul MA, et al. Idiopathic nonlupus full-house nephropathy: clinicopathological presentation and comparison with lupus full-house nephropathy. Saudi J Kidney Dis Transpl 2022; 33(1): 37\u201345. https:\/\/doi.org\/10.4103\/1319-2442.367824","journal-title":"Saudi J Kidney Dis Transpl"},{"key":"e_1_3_6_16_2","doi-asserted-by":"publisher","DOI":"10.4103\/ijn.IJN_91_18"},{"key":"e_1_3_6_17_2","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.0000000000000438"},{"issue":"11","key":"e_1_3_6_18_2","first-page":"1848","article-title":"Lupus or not? Idiopathic full house glomerulonephritis: a rare nephropathy with unexpectedly severe outcome","volume":"43","author":"Sciascia S","year":"2025","unstructured":"Sciascia S, Cozzi M, Fadaeibahreini A, et al. Lupus or not? Idiopathic full house glomerulonephritis: a rare nephropathy with unexpectedly severe outcome. Clin Exp Rheumatol 2025; 43(11): 1848\u20131854.","journal-title":"Clin Exp Rheumatol"},{"issue":"3","key":"e_1_3_6_19_2","doi-asserted-by":"crossref","first-page":"e20240118","DOI":"10.1590\/2175-8239-jbn-2024-0118en","article-title":"Renal outcomes in the long-term follow-up of lupus nephritis","volume":"47","author":"Polycarpo SB","year":"2025","unstructured":"Polycarpo SB, Kirsztajn GM. Renal outcomes in the long-term follow-up of lupus nephritis. J Bras Nefrol 2025; 47(3): e20240118. https:\/\/doi.org\/10.1590\/2175-8239-jbn-2024-0118en","journal-title":"J Bras Nefrol"}],"container-title":["Lupus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09612033261463575","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/09612033261463575","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09612033261463575","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T12:05:29Z","timestamp":1787659529000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/09612033261463575"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,23]]},"references-count":18,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1177\/09612033261463575"],"URL":"https:\/\/doi.org\/10.1177\/09612033261463575","relation":{},"ISSN":["0961-2033","1477-0962"],"issn-type":[{"value":"0961-2033","type":"print"},{"value":"1477-0962","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,23]]}}}