{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T12:26:20Z","timestamp":1787660780407,"version":"build-2736575974"},"reference-count":15,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100005946","name":"Hokkaido University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005946","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We aimed to investigate the long-term thrombotic outcomes in patients with obstetric antiphospholipid syndrome (OAPS) who initially presented without thrombosis and to identify clinical features associated with late thrombotic events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Female patients with antiphospholipid syndrome (APS) and obstetric manifestations diagnosed at Hokkaido University Hospital between 2004 and 2024 were retrospectively analyzed. Patients were first compared cross-sectionally according to the presence or absence of a history of thrombosis at diagnosis. Among those without prior thrombosis, individuals were further analyzed in a nested case-control study comparing patients who developed new thrombotic events with those who remained event-free for more than 10\u00a0years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 47 female APS patients complicated with obstetric manifestations, 23 had a history of thrombosis but not in 24 patients. The prevalence of SLE was higher in the thrombotic group (74%) compared with 40% in the non-thrombotic group (p = 0.019, Fisher\u2019s exact test). During long-term follow-up, 4 of the 24 patients in the absence of prior thrombosis developed a first thrombotic event median of 16\u00a0years after the diagnosis. Of the remaining 20 OAPS patients, 9 patients who were observed for more than 10\u00a0years without any thrombotic events served as the control group and 11 patents with less than 10\u00a0years of follow-up were excluded. The presence of triple antiphospholipid antibodies (aPLs) and accumulation of conventional thrombotic risk factors were more frequent among the cases than the controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Thrombotic events may occur in OAPS patients even decades after diagnosis of OAPS, particularly in those with high-risk aPL profiles and conventional thrombotic risk factors. These findings underscore the importance of long-term vigilance and individualized prevention strategies in OAPS management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09612033261464227","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T07:37:12Z","timestamp":1782200232000},"page":"1075-1081","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Longitudinal observation of thrombotic events in patients with obstetric antiphospholipid syndrome"],"prefix":"10.1177","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-2255-5626","authenticated-orcid":false,"given":"Yuta","family":"Inoue","sequence":"first","affiliation":[{"name":"Hokkaido University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Hokkaido University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4705-341X","authenticated-orcid":false,"given":"Yuichiro","family":"Fujieda","sequence":"additional","affiliation":[{"name":"Hokkaido University"},{"name":"Keio University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3258-9900","authenticated-orcid":false,"given":"Mitsutaka","family":"Yasuda","sequence":"additional","affiliation":[{"name":"Hokkaido University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5319-3174","authenticated-orcid":false,"given":"Kohei","family":"Karino","sequence":"additional","affiliation":[{"name":"Hokkaido University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryo","family":"Hisada","sequence":"additional","affiliation":[{"name":"Hokkaido University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7663-534X","authenticated-orcid":false,"given":"Michihito","family":"Kono","sequence":"additional","affiliation":[{"name":"Hokkaido University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Amengual","sequence":"additional","affiliation":[{"name":"Hokkaido University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5657-962X","authenticated-orcid":false,"given":"Tatsuya","family":"Atsumi","sequence":"additional","affiliation":[{"name":"Hokkaido University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,6,23]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.42624"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-021-02515-w"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/0961203314545410"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.200513"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2006.01753.x"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/35.12.1239"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200009)43:9<1982::AID-ANR9>3.0.CO;2-2"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/jth.15047"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/0961203312458469"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/lupus-2023-001044"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1177\/09612033211038054"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kead292"},{"key":"e_1_3_4_14_2","doi-asserted-by":"crossref","first-page":"e000579","DOI":"10.1136\/lupus-2021-000579","article-title":"Cardiovascular risk management in antiphospholipid syndrome: trends over time and comparison with rheumatoid arthritis and diabetes mellitus","volume":"8","author":"Eleana B","year":"2021","unstructured":"Eleana B, Nikolas T, Petros PS, et al. Cardiovascular risk management in antiphospholipid syndrome: trends over time and comparison with rheumatoid arthritis and diabetes mellitus. Lupus Science & Medicine 2021; 8: e000579.","journal-title":"Lupus Science & Medicine"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.15469"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2019-215213"}],"container-title":["Lupus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09612033261464227","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/09612033261464227","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09612033261464227","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T12:05:26Z","timestamp":1787659526000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/09612033261464227"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,23]]},"references-count":15,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1177\/09612033261464227"],"URL":"https:\/\/doi.org\/10.1177\/09612033261464227","relation":{},"ISSN":["0961-2033","1477-0962"],"issn-type":[{"value":"0961-2033","type":"print"},{"value":"1477-0962","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,23]]}}}