{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T21:32:52Z","timestamp":1792186372671,"version":"4.4.0"},"reference-count":16,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Anifrolumab (ANF) has been approved to treat extra-renal manifestations in Systemic Lupus Erythematosus (SLE) patients. Real-life data underline the excellent efficacy in skin involvement, but very little is known on other manifestations. We conducted a prospective longitudinal analysis to assess ANF efficacy in SLE-related joint involvement by using ultrasound.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We enrolled patients receiving ANF for musculoskeletal manifestations. All the patients were evaluated at baseline (T0) and after 1 (T1) 3 (T3) and 6 (T6) months of treatment.<\/jats:p>\n                    <jats:p>US assessment was performed at level of bilateral hands MCP and PIP joints. According to the OMERACT, we evaluated the presence of US inflammatory features (synovial effusion\/hypertrophy, Power Doppler - pD), measured by semiquantitative score (0\u20133), resulting in a total US inflammatory score (0\u2013180) and total PD score (0\u201360).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Our cohort comprised 13 female patients. During the follow-up period, we found a significant reduction of US scores already after 1 month of treatment, with a further significant reduction after 3 and 6\u00a0months. Interestingly, after 6\u00a0months, 90% of patients showed negativization of pD signal in all the joints. Parallelly, we found a significant improvement in global disease activity indices and in DAS28crp values at all the time-points.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our analysis, made in a real-life scenario, underlines the fast efficacy of ANF on joint synovitis as shown by the reduction in US scores in the early stages of treatment. The rapid effect on pD signal suggest the ability of this drug to prevent the development of erosive damage.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09612033261469032","type":"journal-article","created":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T04:24:06Z","timestamp":1783571046000},"page":"1198-1202","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Anifrolumab induces a fast improvement in ultrasound-detected synovitis in systemic lupus erythematosus: Results from a 6-months follow-up ultrasound study"],"prefix":"10.1177","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5026-8783","authenticated-orcid":false,"given":"Fulvia","family":"Ceccarelli","sequence":"first","affiliation":[{"name":"Sapienza University of Rome"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Ciancarella","sequence":"additional","affiliation":[{"name":"Sapienza University of Rome"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Moretti","sequence":"additional","affiliation":[{"name":"Sapienza University of Rome"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"Iaria","sequence":"additional","affiliation":[{"name":"Sapienza University of Rome"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1969-2097","authenticated-orcid":false,"given":"Francesca Romana","family":"Spinelli","sequence":"additional","affiliation":[{"name":"Sapienza University of Rome"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiano","family":"Alessandri","sequence":"additional","affiliation":[{"name":"Interdisciplinary Department of Wellbeing, Health and Environmental Sustainability (BeSSA), Sapienza University of Rome, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizio","family":"Conti","sequence":"additional","affiliation":[{"name":"Sapienza University of Rome"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,7,8]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard-2023-224762"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2665-9913(19)30076-1"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1912196"},{"key":"e_1_3_3_5_2","doi-asserted-by":"crossref","unstructured":"Ceccarelli F Piga M Bortoluzzi A et al. The role of anifrolumab in reshaping the treatment landscape of extra-renal systemic lupus erythematosus. Reumatismo 2025; 77(4). https:\/\/doi.org\/10.4081\/reumatismo.2025.1830. Epub 2025 Jul 23. PMID: 40704391.","DOI":"10.4081\/reumatismo.2025.1830"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/09612033211051637"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.3390\/jpm13040691"},{"issue":"7","key":"e_1_3_3_8_2","first-page":"415","article-title":"Belimumab is able to induce a significant improvement of joint activity status in patients diagnosed with systemic lupus erythematosus: results from a 12-Month longitudinal study","volume":"22","author":"Ceccarelli F","year":"2020","unstructured":"Ceccarelli F, Cipriano E, Natalucci F, et al. Belimumab is able to induce a significant improvement of joint activity status in patients diagnosed with systemic lupus erythematosus: results from a 12-Month longitudinal study. Isr Med Assoc J 2020; 22(7): 415\u2013419. PMID: 33236565.","journal-title":"Isr Med Assoc J"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2665-9913(21)00317-9"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2024.105830"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.3390\/jpm15110546"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2018-214819"},{"issue":"2","key":"e_1_3_3_13_2","first-page":"288","article-title":"Systemic lupus erythematosus disease activity index 2000","volume":"29","author":"Gladman DD","year":"2002","unstructured":"Gladman DD, Iba\u00f1ez D, Urowitz MB. Systemic lupus erythematosus disease activity index 2000. J Rheumatol 2002; 29(2): 288\u2013291. PMID: 11838846.","journal-title":"J Rheumatol"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2018-214502"},{"issue":"12","key":"e_1_3_3_15_2","first-page":"2485","article-title":"Musculoskeletal ultrasound including definitions for ultrasonographic pathology","volume":"32","author":"Wakefield RJ","year":"2005","unstructured":"Wakefield RJ, Balint PV, Szkudlarek M, et al. Musculoskeletal ultrasound including definitions for ultrasonographic pathology. J Rheumatol 2005; 32(12): 2485\u20132487.","journal-title":"J Rheumatol"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1080\/1744666X.2025.2582494"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.22578"}],"container-title":["Lupus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09612033261469032","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/09612033261469032","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09612033261469032","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T06:31:42Z","timestamp":1789453902000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/09612033261469032"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,8]]},"references-count":16,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1177\/09612033261469032"],"URL":"https:\/\/doi.org\/10.1177\/09612033261469032","relation":{},"ISSN":["0961-2033","1477-0962"],"issn-type":[{"value":"0961-2033","type":"print"},{"value":"1477-0962","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,8]]}}}