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We treated two patients with cases of long-lasting, refractory chilblain LE with the selective, allosteric TYK2-inhibitor deucravacitinib. Both patients showed rapid improvement of their respective skin lesions and symptoms. The treatment was generally well tolerated with no severe adverse events. One of the patients experienced an intermittent occurrence of acne lesions. We therefore suggest deucravacitinib as a promising and safe off-label treatment option for chilblain LE.<\/jats:p>","DOI":"10.1177\/09612033261473986","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T09:07:25Z","timestamp":1785229645000},"page":"1320-1323","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Two cases of therapy-refractory chilblain lupus erythematosus successfully treated with deucravacitinib"],"prefix":"10.1177","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-8454-1538","authenticated-orcid":false,"given":"Robin","family":"Springer","sequence":"first","affiliation":[{"name":"University Hospital Duesseldorf"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Moufarrej","sequence":"additional","affiliation":[{"name":"University Hospital Duesseldorf"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Homey","sequence":"additional","affiliation":[{"name":"University Hospital Duesseldorf"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Meller","sequence":"additional","affiliation":[{"name":"University Hospital Duesseldorf"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,7,28]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.20597"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keac231"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-008-0942-9"},{"key":"e_1_3_4_5_2","first-page":"395","article-title":"Chilblain LE erythematosus (lupus pernio): clinical review of the Mayo Clinic experience and proposal of diagnostic criteria","volume":"54","author":"Su WP","year":"1994","unstructured":"Su WP, Perniciaro C, Rogers RS, et al. 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