{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T12:15:56Z","timestamp":1790079356988,"version":"4.0.1"},"reference-count":37,"publisher":"SAGE Publications","issue":"13","license":[{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Newborns of mothers with autoimmune systemic connective tissue disease (CTD) have a higher incidence of major congenital heart defects (CHDs) compared to unexposed newborns. Less is known about the association between maternal CTD and less severe cardiac abnormalities in the newborn.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analysed prospectively collected echocardiographic data from the Copenhagen Baby Heart Study (CBHS), comparing newborns exposed to maternal CTD with those who were not exposed. Maternal autoimmune CTD diagnoses were identified through the National Patient Register and validated by medical record review. Outcome measures included minor CHDs (atrial and ventricular septal defects, bicuspid aorta valve and patent ductus arteriosus), as well as cardiac dimensions and function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In total 25,590 newborns underwent echocardiography in the CBHS, of whom 57 (0.22%) were born to mothers with CTD. When comparing newborns of mothers with overall CTD to non-exposed newborns, we found no differences in structural and functional cardiac parameters. Minor CHDs were more common in newborns born to mothers with Sj\u00f6gren\u2019s disease (n = 3, 33.3%) than in unexposed newborns (n = 1,945, 7.6%, p = 0.03).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this large population-based study, we did not observe consistent associations between overall maternal CTD and cardiac structure or function in the infant, although minor CHD were more common in newborns exposed to maternal Sj\u00f6gren\u2019s disease. Findings should be interpreted with caution, considering the small sample size of exposed newborns and potential underrepresentation of major CHD due to standard clinical management practices.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09612033261477295","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T13:51:02Z","timestamp":1786629062000},"page":"1395-1406","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Association between maternal autoimmune connective tissue disease and cardiac structure and function in the newborn"],"prefix":"10.1177","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-6711-2938","authenticated-orcid":false,"given":"Terese Frellesen","family":"Neumann","sequence":"first","affiliation":[{"name":"Rigshospitalet"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah Sofie","family":"Andersen","sequence":"additional","affiliation":[{"name":"Rigshospitalet"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofie","family":"Dannesbo","sequence":"additional","affiliation":[{"name":"Rigshospitalet"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Sophie","family":"Sillesen","sequence":"additional","affiliation":[{"name":"Rigshospitalet"},{"name":"Copenhagen University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth Ottilia Birgitta","family":"V\u00f8gg","sequence":"additional","affiliation":[{"name":"Copenhagen University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton Friis","family":"Mariager","sequence":"additional","affiliation":[{"name":"Copenhagen University Hospital"},{"name":"Copenhagen University Hospital \u2013 Amager and Hvidovre"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"R\u00f8nne Wright","sequence":"additional","affiliation":[{"name":"Rigshospitalet"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather Allison","family":"Boyd","sequence":"additional","affiliation":[{"name":"Statens Serum Institut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels","family":"Vejlstrup","sequence":"additional","affiliation":[{"name":"Rigshospitalet"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Schreiber","sequence":"additional","affiliation":[{"name":"Danish Hospital for Rheumatic Diseases"},{"name":"Odense University"},{"name":"Guy\u2019s and St Thomas\u2019 NHS Foundation Trust"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kasper Karmark","family":"Iversen","sequence":"additional","affiliation":[{"name":"Copenhagen University Hospital"},{"name":"University of Copenhagen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henning","family":"Bundgaard","sequence":"additional","affiliation":[{"name":"Rigshospitalet"},{"name":"University of Copenhagen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Axelsson","family":"Raja","sequence":"additional","affiliation":[{"name":"Rigshospitalet"},{"name":"University of Copenhagen"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,8,13]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.pcsu.2010.02.005"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.958405"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.08.025"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.43.3.323"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.183216"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.001054"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000606"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2007.05.005"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.160061"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2017.1326904"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.010027"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2015.29"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12969-023-00803-0"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyab147"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-018-0448-y"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-014-9930-3"},{"issue":"4","key":"e_1_3_5_18_2","first-page":"441","article-title":"The Danish Civil Registration System. A cohort of eight million persons","volume":"53","author":"Pedersen CB","year":"2006","unstructured":"Pedersen CB, G\u00f8tzsche H, M\u00f8ller JO, et al. The Danish Civil Registration System. A cohort of eight million persons. Dan Med Bull 2006; 53(4): 441\u2013449.","journal-title":"Dan Med Bull"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1177\/1403494810394717"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2006.09.001"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)01886-7"},{"key":"e_1_3_5_22_2","doi-asserted-by":"crossref","unstructured":"Dannesbo S Blixenkrone-Moeller E Pihl CA et al. A novel algorithm for classification of interatrial communications within the oval fossa in the newborn: results from the Copenhagen Baby Heart Study Cardiology in the young. 2022; 1\u20138. https:\/\/doi.org\/10.1017\/S1047951122003365","DOI":"10.1017\/S1047951122003365"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-024-03571-0"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.1159\/000529842"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2010.03.019"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kel282"},{"key":"e_1_3_5_27_2","doi-asserted-by":"publisher","DOI":"10.1080\/14767050802388446"},{"key":"e_1_3_5_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2019.05.022"},{"key":"e_1_3_5_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/clc.23173"},{"key":"e_1_3_5_30_2","doi-asserted-by":"publisher","DOI":"10.1080\/14767050500433817"},{"key":"e_1_3_5_31_2","doi-asserted-by":"publisher","DOI":"10.1159\/000538810"},{"key":"e_1_3_5_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2019.02.015"},{"key":"e_1_3_5_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(76)90491-4"},{"key":"e_1_3_5_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2015.03.004"},{"key":"e_1_3_5_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(98)00043-2"},{"key":"e_1_3_5_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2016.137"},{"key":"e_1_3_5_37_2","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0000000000000416"},{"key":"e_1_3_5_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2013.12.002"}],"container-title":["Lupus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09612033261477295","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/09612033261477295","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09612033261477295","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T11:46:13Z","timestamp":1790077573000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/09612033261477295"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,13]]},"references-count":37,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["10.1177\/09612033261477295"],"URL":"https:\/\/doi.org\/10.1177\/09612033261477295","relation":{},"ISSN":["0961-2033","1477-0962"],"issn-type":[{"value":"0961-2033","type":"print"},{"value":"1477-0962","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,13]]}}}