{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:34:18Z","timestamp":1792787658607,"version":"4.5.0"},"reference-count":34,"publisher":"SAGE Publications","issue":"13","license":[{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Anhui Provincial Department of Education University Research Program Project","award":["2023AH030119"],"award-info":[{"award-number":["2023AH030119"]}],"id":[{"id":"https:\/\/ror.org\/012m7k033","id-type":"ROR","asserted-by":"crossref"}]},{"name":"The Research Fund of Anhui Institute of translational medicine","award":["2021zhyx-C21"],"award-info":[{"award-number":["2021zhyx-C21"]}]},{"name":"Anhui Provincial Clinical Medical Research Transformation Project","award":["202304295107020026"],"award-info":[{"award-number":["202304295107020026"]}]},{"name":"Anhui Provincial Natural Science Foundation Project","award":["2508085MH217"],"award-info":[{"award-number":["2508085MH217"]}]},{"name":"Center for Big Data and Population Health of IHM","award":["JKS2022023"],"award-info":[{"award-number":["JKS2022023"]}]},{"name":"The National Natural Science Foundation of China","award":["81803310"],"award-info":[{"award-number":["81803310"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Systemic lupus erythematosus (SLE) is a major autoimmune disease. Recent studies have found that changes in lipid metabolism and gut microbes are associated with the pathogenesis of SLE. However, the coordination of gut commensal bacteria and SLE lipid metabolism is not clear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Gut microbiota profiling was performed using 16S rRNA gene sequencing of fecal samples, and functional prediction was conducted using PICRUSt. Plasma lipidomics was performed using LC\u2013MS. Associations between differentially abundant microbial taxa and differential lipids were assessed using Spearman\u2019s rank correlation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We found obvious abnormalities in lipid metabolism in SLE patients. Sphingolipid metabolism and glycerophospholipid metabolism were the most significantly dysregulated pathways in these patients. There is an obvious intestinal flora imbalance in SLE patients, the\n                      <jats:italic toggle=\"yes\">Becteroides<\/jats:italic>\n                      and\n                      <jats:italic toggle=\"yes\">Lachnoclostridium<\/jats:italic>\n                      is the most important genus to distinguish SLE case groups from control groups. Some differential metabolites in the plasma of SLE patients were correlated with some differential bacteria in the stool. Most of the bacteria associated with lipid changes belonged to\n                      <jats:italic toggle=\"yes\">Firmicutes<\/jats:italic>\n                      ,\n                      <jats:italic toggle=\"yes\">Bacteroidetes, Actinobacteriaceae, Peptostreptococcaceae,<\/jats:italic>\n                      Bacteroidetes,\n                      <jats:italic toggle=\"yes\">Gordonibacter<\/jats:italic>\n                      ,\n                      <jats:italic toggle=\"yes\">Romboutsia<\/jats:italic>\n                      , etc.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings illustrate the disruption of the gut microbiome and lipid group in SLE patients, which may facilitate the development of new SLE interventions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09612033261477298","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T13:55:41Z","timestamp":1786629341000},"page":"1382-1394","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Gut microbiota dysbiosis and plasma lipidomic signatures in systemic lupus erythematosus"],"prefix":"10.1177","volume":"35","author":[{"given":"Jing","family":"Wang","sequence":"first","affiliation":[{"name":"The Second Hospital of Anhui Medical University"},{"name":"The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China"},{"name":"Department of Medical Technology, Clinical College of Anhui Medical University"},{"name":"Anhui Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian-Qian","family":"Zhou","sequence":"additional","affiliation":[{"name":"The Second Hospital of Anhui Medical University"},{"name":"The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China"},{"name":"Department of Medical Technology, Clinical College of Anhui Medical University"},{"name":"Anhui Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Jie","family":"Du","sequence":"additional","affiliation":[{"name":"The Second Hospital of Anhui Medical University"},{"name":"The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China"},{"name":"Department of Medical Technology, Clinical College of Anhui Medical University"},{"name":"Anhui Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[{"name":"The Second Hospital of Anhui Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Cheng","sequence":"additional","affiliation":[{"name":"The Second Hospital of Anhui Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Qin","family":"Zhang","sequence":"additional","affiliation":[{"name":"The Second Hospital of Anhui Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Yuan","family":"Wang","sequence":"additional","affiliation":[{"name":"The Second Hospital of Anhui Medical University"},{"name":"The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China"},{"name":"Department of Medical Technology, Clinical College of Anhui Medical University"},{"name":"Anhui Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhang-Wei","family":"Lu","sequence":"additional","affiliation":[{"name":"The Second Hospital of Anhui Medical University"},{"name":"The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China"},{"name":"Department of Medical Technology, Clinical College of Anhui Medical University"},{"name":"Anhui Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Jin","sequence":"additional","affiliation":[{"name":"The Second Hospital of Anhui Medical University"},{"name":"The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China"},{"name":"Department of Medical Technology, Clinical College of Anhui Medical University"},{"name":"Anhui Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang-Guang","family":"Cao","sequence":"additional","affiliation":[{"name":"The Second Hospital of Anhui Medical University"},{"name":"The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China"},{"name":"Department of Medical Technology, Clinical College of Anhui Medical University"},{"name":"Anhui Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Ting","family":"He","sequence":"additional","affiliation":[{"name":"The Second Hospital of Anhui Medical University"},{"name":"The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China"},{"name":"Department of Medical Technology, Clinical College of Anhui Medical University"},{"name":"Anhui Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Lan","family":"Zhang","sequence":"additional","affiliation":[{"name":"The Second Hospital of Anhui Medical University"},{"name":"The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China"},{"name":"Department of Medical Technology, Clinical College of Anhui Medical University"},{"name":"Anhui Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0936-8269","authenticated-orcid":false,"given":"Long","family":"Qian","sequence":"additional","affiliation":[{"name":"The Second Hospital of Anhui Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8081-9857","authenticated-orcid":false,"given":"Bao-Zhu","family":"Li","sequence":"additional","affiliation":[{"name":"The Second Hospital of Anhui Medical University"},{"name":"The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China"},{"name":"Department of Medical Technology, Clinical College of Anhui Medical University"},{"name":"Anhui Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,8,13]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2020-218272"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)30237-5"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kex260"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2016.08.001"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.02288-17"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.1031079"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12026-017-8906-2"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00976"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-019-0156-z"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4358"},{"key":"e_1_3_5_12_2","doi-asserted-by":"crossref","unstructured":"Olson CA Vuong HE Yano JM et al. The gut microbiota mediates the anti-seizure effects of the ketogenic diet. 174(2):497. https:\/\/doi.org\/10.1016\/j.cell.2018.06.051. Cell. 2018;173(7):1728\u20131741.e13. doi:10.1016\/j.cell.2018.04.027.","DOI":"10.1016\/j.cell.2018.04.027"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1235827"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-015-0542-4"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.833699"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03241-8"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2018-214856"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.41511"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1080\/08916934.2024.2378876"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-83835-0"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1241165"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01548-14"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep08310"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.2217\/fmb-2016-0130"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00360.2012"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13099-016-0146-9"},{"key":"e_1_3_5_27_2","doi-asserted-by":"publisher","DOI":"10.1177\/0961203317707825"},{"key":"e_1_3_5_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(01)00655-4"},{"key":"e_1_3_5_29_2","doi-asserted-by":"publisher","DOI":"10.3390\/biom8040105"},{"key":"e_1_3_5_30_2","doi-asserted-by":"publisher","DOI":"10.1021\/ac403580r"},{"key":"e_1_3_5_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.67"},{"key":"e_1_3_5_32_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01703"},{"key":"e_1_3_5_33_2","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.32"},{"key":"e_1_3_5_34_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2021.637526"},{"key":"e_1_3_5_35_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkae973"}],"container-title":["Lupus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09612033261477298","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/09612033261477298","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09612033261477298","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T11:17:15Z","timestamp":1790075835000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/09612033261477298"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,13]]},"references-count":34,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["10.1177\/09612033261477298"],"URL":"https:\/\/doi.org\/10.1177\/09612033261477298","relation":{},"ISSN":["0961-2033","1477-0962"],"issn-type":[{"value":"0961-2033","type":"print"},{"value":"1477-0962","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,13]]}}}