{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T11:09:56Z","timestamp":1790161796768,"version":"4.1.0"},"reference-count":15,"publisher":"SAGE Publications","issue":"13","license":[{"start":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:00:00Z","timestamp":1787097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001691","name":"JSPS Grant-in-Aid for Scientific Research C","doi-asserted-by":"publisher","award":["23K07668"],"award-info":[{"award-number":["23K07668"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"JSPS Grant-in-Aid for Scientific Research C","doi-asserted-by":"publisher","award":["24K11428"],"award-info":[{"award-number":["24K11428"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Tubulointerstitial lesions predict kidney prognosis in lupus nephritis (LN), but the molecular features of interstitial fibrosis remain incompletely defined. We previously showed that palladin, an actin-associated protein, drives kidney fibrosis through actin dynamics. This study examined whether interstitial palladin expression is associated with histopathology and prognosis in LN.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed Japanese patients with biopsy-proven LN at Kanazawa University Hospital between 1990 and 2018. Palladin-positive area was quantified by immunohistochemistry and log2-transformed (log2 palladin). The colocalization of palladin and \u03b1-smooth muscle actin (\u03b1SMA) was investigated by immunofluorescence. Associations with modified NIH activity and chronicity indices were assessed using Spearman correlation. Event-free survival for renal replacement therapy (RRT) initiation or all-cause death was evaluated by Kaplan-Meier analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Thirty-four patients were included. Palladin was predominantly expressed in the kidney interstitium and colocalized with \u03b1SMA-positive cells. Log2 palladin correlated with the modified NIH chronicity index (\u03c1 = 0.61,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.01), tubular atrophy (\u03c1 = 0.53,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.01), interstitial fibrosis (\u03c1 = 0.56,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.01), and interstitial inflammation (\u03c1 = 0.55,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.01), but not with the total activity index (\u03c1 = 0.24,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.16). During a median follow-up of 10.1\u00a0years (IQR, 3.3\u201317.5), seven patients reached the composite outcome. The composite outcome occurred in five patients in the high-palladin group and two patients in the low-palladin group, and high palladin expression was associated with poorer event-free survival by Kaplan\u2013Meier analysis (log-rank\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.04).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Interstitial palladin expression may reflect tubulointerstitial chronicity and be associated with poor outcomes in LN; however, its independent prognostic value could not be established due to the limited number of events.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09612033261479120","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T05:55:45Z","timestamp":1787205345000},"page":"1433-1439","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Interstitial palladin is associated with tubulointerstitial chronicity and adverse outcomes in patients with lupus nephritis"],"prefix":"10.1177","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4113-0499","authenticated-orcid":false,"given":"Naoki","family":"Yamamoto","sequence":"first","affiliation":[{"name":"Kanazawa University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norihiko","family":"Sakai","sequence":"additional","affiliation":[{"name":"Kanazawa University"},{"name":"Kanazawa 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