{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T05:32:48Z","timestamp":1793079168079,"version":"4.5.0"},"reference-count":24,"publisher":"SAGE Publications","issue":"14","license":[{"start":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:00:00Z","timestamp":1787529600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"the Gusu Health Talent Plan of Suzhou","award":["GSWS2022043"],"award-info":[{"award-number":["GSWS2022043"]}]},{"name":"the Gusu Health Talent Plan of Suzhou","award":["2022194"],"award-info":[{"award-number":["2022194"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Lupus"],"published-print":{"date-parts":[[2026,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aimed to explore the clinical characteristics of patients with late-onset systemic lupus erythematosus (SLE) during the initial stage of disease onset and to evaluate disease activity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>Data from patients with SLE whose disease onset was \u22643\u00a0months were retrospectively collected, and the patients were classified into the late- and early-onset SLE groups based on an age cutoff of 50\u00a0years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      This study included 145 patients, including 31 with late-onset SLE and 114 with early-onset SLE. Compared with the early-onset SLE group, the late-onset SLE group had a lower prevalence of rash (25.8% vs. 45.6%,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.040) and anti-dsDNA antibody positivity (54.8% vs. 72.5%,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.027), whereas pericarditis was more frequent (29.0% vs. 12.3%,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.047) and the C3 levels were higher (0.640 [0.400, 0.892]\u00a0g\/L vs. 0.460 [0.324, 0.701]\u00a0g\/L,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.018). As regards disease activity, the SLEDAI 2000 was 10 (8, 20) in the late-onset SLE group and 15 (10, 22) in the early-onset SLE group (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.066), whereas the SLE-DAS was similar between the groups (13.33 [11.50, 28.45] vs 15.48 [8.56, 25.18],\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.744). More than half of patients with late-onset SLE received high-dose or intravenous pulse corticosteroid therapy, with no statistically significant difference compared with patients with early-onset SLE.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patients with very early-stage late-onset SLE exhibited distinct clinical and serological features. However, their disease activity was essentially consistent with that of early-onset SLE, and they often require intensive immunosuppressive therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09612033261481990","type":"journal-article","created":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T07:20:57Z","timestamp":1787556057000},"page":"1472-1478","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical characteristics of patients with late-onset systemic lupus erythematosus with a disease onset of \u2264 3\u00a0months"],"prefix":"10.1177","volume":"35","author":[{"given":"Mengxue","family":"Yan","sequence":"first","affiliation":[{"name":"The Second Affiliated Hospital of Soochow University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siping","family":"Li","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Soochow University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyi","family":"Lu","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Soochow University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhichun","family":"Liu","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Soochow University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8415-7088","authenticated-orcid":false,"given":"Leixi","family":"Xue","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Soochow University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,8,24]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-024-05784-1"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-006-0284-3"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/0961203313513508"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-016-3450-2"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.md.0000147737.57861.7c"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-013-2238-y"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/0961203308089695"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2024.101938"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/0961203312450087"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keaa477"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.080957"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1177\/0961203314563134"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780400928"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.34473"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2018-214819"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard-2023-224762"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2021-220363"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780390303"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40266-025-01245-x"},{"key":"e_1_3_3_21_2","first-page":"145","article-title":"Similarities and differences between younger and older disease onset patients with newly diagnosed systemic lupus erythematosus","volume":"41","author":"Prevete I","year":"2023","unstructured":"Prevete I, Iuliano A, Cauli A, et al. Similarities and differences between younger and older disease onset patients with newly diagnosed systemic lupus erythematosus. 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