{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T15:12:47Z","timestamp":1779289967397,"version":"3.51.4"},"reference-count":31,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[1994,6,1]],"date-time":"1994-06-01T00:00:00Z","timestamp":770428800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lupus"],"published-print":{"date-parts":[[1994,6]]},"abstract":"<jats:p>The objective of this work was to analyse the course of maternal disease and fetal outcome in pregnant patients with systemic lupus erythematosus (SLE) counselled and followed according to a protocol intended to optimize maternal and fetal outcome. The prospective study included all pregnancies between 1987 and 1993 in SLE patients known at least 6 months before pregnancy at the Lupus Clinic of our hospital. In 25 patients there were 35 pregnancies. Thirty-four (97%) started at sustained remission of disease; 11 (31%) were in women with antiphospholipid antibodies (aPL); 14 (40%) in women with a history of biopsy-proven lupus nephritis; one (3% in a woman with a serum creatinine above 125 \u03bcmol\/l. In 29 pregnancies (82%) maternal disease remained inactive during gestation. In three pregnancies (9%) active disease was treated with prednisone. There were no serious post-partum flares of disease. Pregnancy resulted in 25 (71%) live births, 8 (23%) first trimester abortions, and one intrauterine fetal death. One pregnancy was terminated because of hydrocephalus. Nine of 25 (36%) live births were delivered by caesarean section. For 6 of 9 (67%) caesarean sections the indication was fetal distress and pre-eclampsia.<\/jats:p>\n                  <jats:p>In the majority of patients with SLE who conceive at remission, the disease does not flare in pregnancy. With optimal obstetric care, close follow-up and treatment with low-dose aspirin if aPL are present, a high success rate (71%) can be achieved.<\/jats:p>","DOI":"10.1177\/096120339400300304","type":"journal-article","created":{"date-parts":[[2007,11,26]],"date-time":"2007-11-26T19:27:11Z","timestamp":1196105231000},"page":"149-155","source":"Crossref","is-referenced-by-count":51,"title":["Pregnancy in Systemic Lupus Erythematosus: a Prospective Study"],"prefix":"10.1177","volume":"3","author":[{"given":"Ronald H.W.M.","family":"Derksen","sequence":"first","affiliation":[{"name":"Departments of Internal Medicine (Section of Clinical Immunology and Infectious Diseases), Obstetrics and Gynecology; Haematology, University Hospital Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hein W.","family":"Bruinse","sequence":"additional","affiliation":[{"name":"Departments of Internal Medicine (Section of Clinical Immunology and Infectious Diseases), Obstetrics and Gynecology; Haematology, University Hospital Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip G.","family":"de Groot","sequence":"additional","affiliation":[{"name":"Departments of Internal Medicine (Section of Clinical Immunology and Infectious Diseases), Obstetrics and Gynecology; Haematology, University Hospital Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louis","family":"Kater","sequence":"additional","affiliation":[{"name":"Departments of Internal Medicine (Section of Clinical Immunology and Infectious Diseases), Obstetrics and Gynecology; Haematology, University Hospital Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1994,6,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.46.9.664"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(12)60294-8"},{"key":"atypb3","unstructured":"Wallace DJ Prognostic subsets and mortality in systemic lupus erythematosus. In: Dubois' Lupus Erythematosus. Wallace DJ, Hahn BH (eds). 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