{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T07:13:38Z","timestamp":1780557218778,"version":"3.54.1"},"reference-count":32,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[1995,2,1]],"date-time":"1995-02-01T00:00:00Z","timestamp":791596800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lupus"],"published-print":{"date-parts":[[1995,2]]},"abstract":"<jats:p>Recent studies have suggested an association between primary antiphospholipid syndrome (PAPS), antiphospholipid antibodies and some major histocompatibility complex (MHC) antigens. We have studied the relationship between MHC class II antigens and PAPS in 19 patients from the south of Spain. Univariant analysis showed an association between PAPS and HLA-DQ7 (47% vs 25%1 P = 0.03), DR4 (32% vs 16%; P = 0.08) and DQ3 (63% vs 39%; P = 0.04). However, multivariant analysis confirmed the association with DQ7 (RR = 2.5; CI 80%:1.3-4.7) and DR4 (RR = 2.2; CI 80%:1.1-4.4) but not with DQ3. When we introduced DRw53 into this analysis, we noticed a DR4 confounding effect, with DQ7 (RR = 3.1; CI 80%: 1.7-5.8) and Drw53 (RR = 2.3; CI 80%: 1.2-4.4) remaining as the most important HLA antigens related to PAPS. In conclusion, in PAPS patients from the South of Spain, HLA-DQ7 antigen showed the highest relative risk for PAPS, followed by DRw53.<\/jats:p>","DOI":"10.1177\/096120339500400111","type":"journal-article","created":{"date-parts":[[2007,11,26]],"date-time":"2007-11-26T19:27:11Z","timestamp":1196105231000},"page":"51-55","source":"Crossref","is-referenced-by-count":30,"title":["Association between HLA class II antigens and primary antiphospholipid syndrome from the South of Spain"],"prefix":"10.1177","volume":"4","author":[{"given":"MT","family":"Camps","sequence":"first","affiliation":[{"name":"Unidad de Enfermedades Autoimmunes Sist\u00e9micas, Servicio de Medicina Interna, Hospital Regional del Servicio Andaluz de S alud, M\u00e1laga"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MJ","family":"Cuadrado","sequence":"additional","affiliation":[{"name":"Secci\u00f3n de Reumatologia, Hospital Universitario 'Reina Sofia', C\u00f3rdoba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Oc\u00f3n","sequence":"additional","affiliation":[{"name":"Secci6n de Immunologia, Hospital Regional del Servicio Andaluz de Salud"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Alonso","sequence":"additional","affiliation":[{"name":"Secci6n de Immunologia, Hospital Regional del Servicio Andaluz de Salud"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Gutierrez","sequence":"additional","affiliation":[{"name":"Seccion de Bioquimica, Servicio de Laboratorio, Hospital Regional del Servicio Andaluz de Salud, M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Guil","sequence":"additional","affiliation":[{"name":"Unidad de Enfermedades Autoimmunes Sist\u00e9micas, Servicio de Medicina Interna, Hospital Regional del Servicio Andaluz de S alud, M\u00e1laga"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MI","family":"Grana","sequence":"additional","affiliation":[{"name":"Unidad de Enfermedades Autoimmunes Sist\u00e9micas, Servicio de Medicina Interna, Hospital Regional del Servicio Andaluz de S alud, M\u00e1laga"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"de Ram\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[1995,2,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-198911000-00004"},{"key":"atypb2","first-page":"1742","volume":"15","author":"Asherson RA","year":"1988","journal-title":"J Rheumatol"},{"key":"atypb3","first-page":"561","volume":"102","author":"Vivancos J.","year":"1994","journal-title":"Med Clin"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780311216"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.1991.tb00715.x"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.3109\/08916939209001909"},{"key":"atypb7","first-page":"1393","volume":"19","author":"Dagenais P.","year":"1992","journal-title":"J Rheumatol"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1002\/anr.1780321222"},{"key":"atypb9","first-page":"425","volume":"8","author":"McNeil HP","year":"1990","journal-title":"Clin Exp Rheumatol"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780360413"},{"issue":"1","key":"atypb11","first-page":"33","volume":"1","author":"Galleazzi M.","year":"1992","journal-title":"Lupus"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115158"},{"key":"atypb13","first-page":"644","volume":"4","author":"Reveille JD","year":"1992","journal-title":"Curr Opin Rheumatol"},{"key":"atypb14","first-page":"1684","volume":"20","author":"Gulko PS","year":"1993","journal-title":"Arthritis Rheum"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780350119"},{"key":"atypb16","doi-asserted-by":"crossref","first-page":"S125","DOI":"10.1002\/art.1780330826","volume":"33","author":"Goldstein B.","year":"1990","journal-title":"Arthritis Rheum"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/26.5.324"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)91477-4"},{"key":"atypb19","volume-title":"Antinuclear Antibodies. Contemporary Techniques and Clinical Application to Connective Tissue Disease","author":"McCarty GA","year":"1984"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1975.tb29197.x"},{"key":"atypb21","unstructured":"Ouchterlony O. , Nilsson LA Immunodiffusion and immunoelectrophoresis . In: Handbook of Experimental Immunology, vol. 1. Immunochemistry. Weir DM (ed.). Oxford: Blackwell Scientific Publications, 1986: 32.1-32.5."},{"key":"atypb22","first-page":"709","volume":"54","author":"Exner T.","year":"1978","journal-title":"Br J Haematol"},{"key":"atypb23","first-page":"738","volume":"62","author":"Loizou S.","year":"1985","journal-title":"Clin Exp Immunol"},{"key":"atypb24","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/94.4.476"},{"key":"atypb25","first-page":"585","volume":"9","author":"Camps Garcia MT","year":"1992","journal-title":"Ann Med Intern"},{"key":"atypb26","volume-title":"Microdroplet assay for human blood lymphotoxins","author":"Terasaki PI","year":"1965"},{"key":"atypb27","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1992.tb01932.x"},{"key":"atypb28","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/30.2.156"},{"key":"atypb29","doi-asserted-by":"publisher","DOI":"10.1016\/S0171-2985(11)80210-X"},{"key":"atypb30","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780331012"},{"key":"atypb31","first-page":"12","volume":"102","author":"Camps Garcia MT","year":"1994","journal-title":"Med Clin"},{"key":"atypb32","doi-asserted-by":"publisher","DOI":"10.1136\/ard.51.3.353"}],"container-title":["Lupus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/096120339500400111","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/096120339500400111","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:32:04Z","timestamp":1777678324000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/096120339500400111"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,2]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1995,2]]}},"alternative-id":["10.1177\/096120339500400111"],"URL":"https:\/\/doi.org\/10.1177\/096120339500400111","relation":{},"ISSN":["0961-2033","1477-0962"],"issn-type":[{"value":"0961-2033","type":"print"},{"value":"1477-0962","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,2]]}}}