{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T01:12:01Z","timestamp":1792113121194,"version":"4.4.0"},"reference-count":41,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[1995,6,1]],"date-time":"1995-06-01T00:00:00Z","timestamp":801964800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lupus"],"published-print":{"date-parts":[[1995,6]]},"abstract":"<jats:p>\n                    MRL-lpr\/lpr mice are genetically predisposed to develop a systemic lupus erythematosus-like syndrome that is clinically very similar to the human disease. The results presented here demonstrate, for the first time to our knowledge, that MRL-lpr\/lpr mice also develop thyroiditis as part of their systemic autoimmune disorder. The thyroid gland was infiltrated by immunocomponent cells with defined lymphoid follicular centers and extensive interstitial lymphocytes dispersed throughout the thyroid epithelium. All the diseased mice were hypothyroid with reduced, relative levels of thyroid hormone (free T\n                    <jats:sub>4<\/jats:sub>\n                    ) and elevated levels of thyroid-stimulating hormone (TSH). They also had high concentrations of circulating IgG class autoantibodies directed against thyroglobulin, thyroperoxidase and double-stranded DNA. The MRL-+\/+ age-matched allelic counterpart mice had relatively few lymphocytes in their thyroid tissue, and normal levels of thyroxine and TSH. The non-diseased mice also had undetectable levels of thyroid reactive autoantibodies tested for by enzyme-linked immunosorbent assays. Collectively these findings document that the MRL-lpr\/lpr mice spontaneously develop autoimmune thyroiditis and can be used as a model for the study of thyroid-specific autoimmunity.\n                  <\/jats:p>","DOI":"10.1177\/096120339500400305","type":"journal-article","created":{"date-parts":[[2007,11,26]],"date-time":"2007-11-26T19:27:11Z","timestamp":1196105231000},"page":"187-196","source":"Crossref","is-referenced-by-count":16,"title":["Characterization of autoimmune thyroiditis in MRL-lpr\/lpr mice"],"prefix":"10.1177","volume":"4","author":[{"given":"L.M.","family":"Green","sequence":"first","affiliation":[{"name":"JL Pettis Veterans Medical Center, Department of Research-151, 11201 Benton Street, Loma Linda, CA 92357, Department of Microbiology\/Physiology, Loma Linda University Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"LaBue","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Loma Linda University Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.P.","family":"Lazarus","sequence":"additional","affiliation":[{"name":"Department of Physiology, Loma Linda University Medical School"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.K.","family":"Colburn","sequence":"additional","affiliation":[{"name":"Department of Medicine, JL Pettis Vetarans Medical Center and Loma Linda University Medical School. Loma Linda, CA 92350. USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[1995,6,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/S0307-742X(21)00244-7","volume":"4","author":"Dayer JM","year":"1978","journal-title":"Clin Rheum Dis"},{"key":"atypb2","unstructured":"Oertel JE, LiVolsi A. Pathology of thyroid diseases. In: Braverman LE, Utiger RD (eds). Werner and Ingbar's The Thyroid. Lippincott JB: Philadelphia, 1991, pp 603-642."},{"key":"atypb3","unstructured":"McKenzie MJ, Zakarija M. Antibodies in autoimmune thyroid disease. In: Braverman LE, Utiger RD (eds). Werner and Ingbar's The Thyroid. 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