{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:15:30Z","timestamp":1777929330774,"version":"3.51.4"},"reference-count":61,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[1997,1,1]],"date-time":"1997-01-01T00:00:00Z","timestamp":852076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lupus"],"published-print":{"date-parts":[[1997,1]]},"abstract":"<jats:p>Patients with subacute cutaneous lupus erythematosus (SCLE) have recurrent annular and\/or psoriasiphorm skin lesions, with or without systemic disease.<\/jats:p>\n                  <jats:p>Objective: To analyse the clinical expression and the Ro\/SS-A response associated with SCLE in patients with systemic lupus erythematosus (SLE).<\/jats:p>\n                  <jats:p>Methods: 128 consecutive patients with SLE were studied. Anti-Ro\/SS-A antibodies were detected by ELISA, (anti-60 kD Ro\/SSA antibodies), immunoblotting (anti-60 kD and anti-52 kD Ro\/SS-A antibodies) and counterimmunoelectrophoresis (CIE).<\/jats:p>\n                  <jats:p>Results: Seventeen patients (13.2%) showed SCLE lesions. Photosensitivity was more frequent in patients with SCLE (82%) than in patients without these cutaneous lesions (45%) (OR: 5.6). Arthritis (OR: 6.3), Raynaud's phenomenon (OR: 4.9), pleuritis (OR: 7.6), central nervous system disorder (OR: 6.4), renal disease (OR: 6.3), anemia (OR: 7.9), hypocomplementemia (OR: 6.1) and anti-dsDNA antibodies (OR: 12.7) were significantly more frequent in patients without SCLE. Anti-Ro\/SS-A antibodies were detected in 15 (88.2%) patients with SCLE and 62 (55.8%) patients without SCLE by ELISA, in 10 (58.8%) and 34 (30.6%) patients by immunoblotting, and in 13 (76.4%) and 34 (30.6%) by CIE, respectively. Anti-60 kD-Ro\/SS-A and anti-La antibodies, but not anti-52 kD-Ro\/SS-A, were significantly more frequent in patients with SCLE than in patients without SCLE.<\/jats:p>\n                  <jats:p>Conclusions: The presence of SCLE lesions in patients with SLE is associated with a more favourable prognosis. The major anti-Ro\/SS-A response is directed against the native 60 kD Ro\/SSA protein.<\/jats:p>","DOI":"10.1177\/096120339700600105","type":"journal-article","created":{"date-parts":[[2009,11,6]],"date-time":"2009-11-06T19:26:09Z","timestamp":1257535569000},"page":"32-39","source":"Crossref","is-referenced-by-count":20,"title":["Systemic lupus erythematosus: clinical expression and anti-Ro\/SS\u2014A response in patients with and without lesions of subacute cutaneous lupus erythematosus"],"prefix":"10.1177","volume":"6","author":[{"given":"FJ","family":"L\u00f3pez-Longo","sequence":"first","affiliation":[{"name":"Service of Rheumatology and Experimental Medicine Unit, 'Gregorio Mara\u00f1\u00f3n' Hospital, Universidad Complutense of Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Monteagudo","sequence":"additional","affiliation":[{"name":"Service of Rheumatology and Experimental Medicine Unit, 'Gregorio Mara\u00f1\u00f3n' Hospital, Universidad Complutense of Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CM","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Service of Rheumatology and Experimental Medicine Unit, 'Gregorio Mara\u00f1\u00f3n' Hospital, Universidad Complutense of Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Grau","sequence":"additional","affiliation":[{"name":"Service of Rheumatology and Experimental Medicine Unit, 'Gregorio Mara\u00f1\u00f3n' Hospital, Universidad Complutense of Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Carre\u00f1o","sequence":"additional","affiliation":[{"name":"Service of Rheumatology and Experimental Medicine Unit, 'Gregorio Mara\u00f1\u00f3n' Hospital, Universidad Complutense of Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1997,1,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(81)80261-7"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1979.04010120007006"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-97-5-664"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1994.01690100046006"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1994.01690100092016"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1016\/0738-081X(85)90078-1"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-7125(16)30620-4"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310811"},{"key":"atypb9","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1007\/s001050050151","volume":"45","author":"Tebbe B.","year":"1994","journal-title":"Hautarzt"},{"key":"atypb10","first-page":"1665","volume":"21","author":"Cohen MR","year":"1995","journal-title":"J Rheumatol"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780251101"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780190309"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1994.tb13331.x"},{"key":"atypb14","first-page":"682","volume":"194","author":"L\u00f3pez-Longo FJ","year":"1994","journal-title":"Rev Cl\u00edn Esp"},{"key":"atypb15","doi-asserted-by":"crossref","first-page":"117","DOI":"10.4049\/jimmunol.102.1.117","volume":"102","author":"Clark GM","year":"1969","journal-title":"J Immunol"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780340613"},{"key":"atypb17","first-page":"1450","volume":"21","author":"L\u00f3pez-Longo FJ","year":"1994","journal-title":"J Rheumatol"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.76.9.4350"},{"key":"atypb19","unstructured":"Hill HS Systemic lupus erythematosus and mixed connective tissue disease. 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