{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:16:02Z","timestamp":1777929362592,"version":"3.51.4"},"reference-count":31,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[1997,9,1]],"date-time":"1997-09-01T00:00:00Z","timestamp":873072000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lupus"],"published-print":{"date-parts":[[1997,9]]},"abstract":"<jats:p>\n                    We developed a novel assay using human thrombomodulin (TM), which detected overall abnormalities in the protein C anticoagulant pathway (PC pathway). This assay indicates the degree of inhibition of prothrombinase by TM, which is represented as the percentage of prothrombinase inhibition by 25 ng\/ml of TM, termed PIP\n                    <jats:sub>25<\/jats:sub>\n                    (Prothrombinase Inhibition Percentage). We examined PIP\n                    <jats:sub>25<\/jats:sub>\n                    in plasma samples from patients with systemic lupus erythematosus (SLE) with or without lupus anticoagulant (LA), patients with Behret's disease (BD), and patients with miscellaneous thrombotic vasculitis and compared these with the PIP\n                    <jats:sub>25<\/jats:sub>\n                    of plasma samples from healthy volunteers in Japan. The PIP\n                    <jats:sub>25<\/jats:sub>\n                    s were significantly lower in SLE alone (35.5 \u00b1 12.8%, P = 0.036) and SLE with LA (33.0 \u00b1 13.3%, P = 0.030) and BD (33.3 \u00b1 13.4%, P = 0.010) than those in healthy volunteers (43.5 \u00b1 10.7%). There was no significance between healthy PIP\n                    <jats:sub>25<\/jats:sub>\n                    and those with miscellaneous thrombotic vasculitis (44.2\u00b18.4%, P = 0.823). These results suggest that the abnormalities of the protein C anticoagulant pathway were present in patients with SLE(LA) and BD.\n                  <\/jats:p>","DOI":"10.1177\/096120339700600706","type":"journal-article","created":{"date-parts":[[2007,11,26]],"date-time":"2007-11-26T19:27:11Z","timestamp":1196105231000},"page":"590-596","source":"Crossref","is-referenced-by-count":12,"title":["Review : Abnormalities in the protein C anticoagulant pathway detected by a novel assay using human thrombomodulin"],"prefix":"10.1177","volume":"6","author":[{"given":"M.","family":"Mohri","sequence":"first","affiliation":[{"name":"Laboratory for Pharmacology, Institute for Life Science Research, Asahi Chemical Industry Co., Ltd, Oh-hito, Tagata, Shizuoka 410-23"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Sata","sequence":"additional","affiliation":[{"name":"Laboratory for Pharmacology, Institute for Life Science Research, Asahi Chemical Industry Co., Ltd, Oh-hito, Tagata, Shizuoka 410-23"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Gomi","sequence":"additional","affiliation":[{"name":"Laboratory for Pharmacology, Institute for Life Science Research, Asahi Chemical Industry Co., Ltd, Oh-hito, Tagata, Shizuoka 410-23"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Maruyama","sequence":"additional","affiliation":[{"name":"Third Internal Medicine, Kagoshima University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Osame","sequence":"additional","affiliation":[{"name":"Third Internal Medicine, Kagoshima University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Maruyama","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Medicine, Kagoshima University School of Medicine, Kagoshima, Kagoshima 810, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1997,9,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1001895"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117458"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1007\/BF01738943"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V85.10.2756.bloodjournal85102756"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1642558"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1038\/369064a0"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V82.7.1989.1989"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)80081-9"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199402243300801"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1097\/00001721-199402000-00008"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1647634"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1172\/JCI116382"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V79.11.2930.2930"},{"key":"atypb14","unstructured":"Sirridge MS, Shannon R. 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