{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T02:11:22Z","timestamp":1790475082978,"version":"4.1.0"},"reference-count":18,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[1999,7,1]],"date-time":"1999-07-01T00:00:00Z","timestamp":930787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lupus"],"published-print":{"date-parts":[[1999,7]]},"abstract":"<jats:p>\n                    Objective: To clarify the prevalence and etiology of ectopic calcification in patients with systemic lupus erythematosus (SLE), especially under the active vitamin D\n                    <jats:sub>3<\/jats:sub>\n                    administrations and to reveal the risk factors of ectopic calcification.\n                  <\/jats:p>\n                  <jats:p>Methods: Sixty patients with SLE, excluding the patients on dialysis were studied. We examined radiographs of hands, forearms, upper and lower extremities, and pelvises of all patients to evaluate ectopic calcification.<\/jats:p>\n                  <jats:p>Results: The prevalence of ectopic calcification in SLE was 40% (24 out of 60 patients), found in 6.7% (4 patients) in peripheral arteries, 33.3% (20 patients) in periarticular area and 16.7% (10 patients) in other soft tissues. The incidence of lupus nephritis and nephrotic syndrome were significantly higher (respectively: P = 0.0144 and P = 0.0348) in the calcification-positive than negative group. Total protein levels (7.04 0.6 g =dl) of patients in the calcification-positive group were decreased significantly (P = 0.0056) compared with 7.48 0.55 g =dl in the negative group. However, other biochemical parameters were not significantly different between the two groups. Sixty-three percent of the SLE patients with ectopic calcification received alfacarcidol, which is significantly (P = 0.0007) higher than the 19% in patients without calcification.<\/jats:p>\n                  <jats:p>Conclusion: It is suggested that the alfacarcidol therapy and lupus nephritis could increase the risk of ectopic calcification in SLE patients.<\/jats:p>","DOI":"10.1177\/096120339900800608","type":"journal-article","created":{"date-parts":[[2006,11,2]],"date-time":"2006-11-02T22:11:54Z","timestamp":1162505514000},"page":"456-461","source":"Crossref","is-referenced-by-count":27,"title":["Prevalence of soft tissue calcifications in patients with SLE and effects of alfacarcidol"],"prefix":"10.1177","volume":"8","author":[{"given":"J","family":"Okada","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Nomura","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine Kitasato                         University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Shirataka","sequence":"additional","affiliation":[{"name":"Department of Medical Informatics, Kitasato University School of                         Medicine, Kitasato, Sagamihara, Kanagawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Kondo","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine Kitasato                         University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[1999,7,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1975.01630150072008"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1148\/126.2.313"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1983.tb02161.x"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1990.01670320084015"},{"key":"atypb5","first-page":"574","volume":"26","author":"Sugimoto H","year":"1999","journal-title":"J Rheumatol"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198308043090509"},{"key":"atypb7","first-page":"600","volume-title":"Dubois' Lupus Erythematosus","author":"Wallace DJ","year":"1992"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199306173282404"},{"key":"atypb9","first-page":"995","volume":"23","author":"Adachi JD","year":"1996","journal-title":"J Rheumatol"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1990.293"},{"key":"atypb11","first-page":"855","volume":"24","author":"Southwood R","year":"1990","journal-title":"DICP (new title: Ann Pharmacother)"},{"key":"atypb12","first-page":"91","volume":"13","author":"Matsukawa Y","year":"1995","journal-title":"Clin Exp Rheumatol"},{"key":"atypb13","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1002\/art.1780251101","volume":"25","author":"TanEM","year":"1982","journal-title":"Arthritis Rheum"},{"key":"atypb14","first-page":"1436","volume":"78","author":"John AS","year":"1994","journal-title":"J Clin Endocrinol Metab"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8529(18)30365-7"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1080\/00325481.1993.11701716"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(88)91260-1"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(12)80614-7"}],"container-title":["Lupus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/096120339900800608","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/096120339900800608","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:35:03Z","timestamp":1777678503000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/096120339900800608"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,7]]},"references-count":18,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1999,7]]}},"alternative-id":["10.1177\/096120339900800608"],"URL":"https:\/\/doi.org\/10.1177\/096120339900800608","relation":{},"ISSN":["0961-2033","1477-0962"],"issn-type":[{"value":"0961-2033","type":"print"},{"value":"1477-0962","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,7]]}}}