{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T21:20:35Z","timestamp":1792704035847,"version":"4.5.0"},"reference-count":25,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Stat Methods Med Res"],"published-print":{"date-parts":[[2009,2]]},"abstract":"<jats:p>The self-controlled case series method is increasingly being used in pharmacoepidemiology, particularly in vaccine safety studies. This method is typically used to evaluate the association between a transient exposure and an acute event, using only cases. We present both parametric and semiparametric models using a motivating example on MMR vaccine and bleeding disorders. We briefly describe approaches for interferent events and a sequential version of the method for prospective surveillance of drug safety. The efficiency of the self-controlled case series method is compared to the that of cohort and case control studies. Some further extensions, to long or indefinite exposures and to bivariate counts, are described.<\/jats:p>","DOI":"10.1177\/0962280208092342","type":"journal-article","created":{"date-parts":[[2008,6,18]],"date-time":"2008-06-18T20:34:15Z","timestamp":1213821255000},"page":"7-26","source":"Crossref","is-referenced-by-count":201,"title":["The methodology of self-controlled case series studies"],"prefix":"10.1177","volume":"18","author":[{"given":"Heather J","family":"Whitaker","sequence":"first","affiliation":[{"name":"Department of Mathematics and Statistics, The Open University, Milton Keynes, MK7 6AA, UK,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mounia N","family":"Hocine","sequence":"additional","affiliation":[{"name":"Department of Mathematics and Statistics, The Open University, Milton Keynes, MK7 6AA, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C Paddy","family":"Farrington","sequence":"additional","affiliation":[{"name":"Department of Mathematics and Statistics, The Open University, Milton Keynes, MK7 6AA, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2009,2,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.2307\/2533328"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)90471-9"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)01239-8"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwg114"},{"key":"atypb5","first-page":"553","volume":"55","author":"Farrington CP","year":"2006","journal-title":"Applied Statistics"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1016\/j.csda.2007.06.016"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1136\/adc.84.3.227"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1002\/sim.2302"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa041747"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1002\/sim.2477"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a115853"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2004.01.017"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa003077"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)90471-9"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1001\/archfami.9.7.617"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1159\/000059520"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2007.05.032"},{"key":"atypb18","author":"Farrington CP","year":"2008","journal-title":"Biometrics"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2005.041798"},{"key":"atypb20","author":"Hocine MN","journal-title":"Journal of the Royal statistical Society series A"},{"key":"atypb21","doi-asserted-by":"publisher","DOI":"10.4161\/hv.2790"},{"key":"atypb22","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(01)00097-4"},{"key":"atypb23","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2006.07.014"},{"key":"atypb24","doi-asserted-by":"publisher","DOI":"10.1002\/sim.2413"},{"key":"atypb25","first-page":"585","volume":"55","author":"Hocine M.","year":"2006","journal-title":"Applied Statistics"}],"container-title":["Statistical Methods in Medical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0962280208092342","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0962280208092342","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T23:43:56Z","timestamp":1777679036000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0962280208092342"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,2]]}},"alternative-id":["10.1177\/0962280208092342"],"URL":"https:\/\/doi.org\/10.1177\/0962280208092342","relation":{},"ISSN":["0962-2802","1477-0334"],"issn-type":[{"value":"0962-2802","type":"print"},{"value":"1477-0334","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,2]]}}}