{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,2]],"date-time":"2025-03-02T05:52:43Z","timestamp":1740894763795,"version":"3.38.0"},"reference-count":53,"publisher":"SAGE Publications","issue":"10-11","license":[{"start":{"date-parts":[[2018,8,27]],"date-time":"2018-08-27T00:00:00Z","timestamp":1535328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"National Institutes of Health, National Institute on Drug Abuse","award":["K24 DA022288"],"award-info":[{"award-number":["K24 DA022288"]}]},{"name":"National Institutes of Health, National Institute on Drug Abuse","award":["R21 DA042847"],"award-info":[{"award-number":["R21 DA042847"]}]},{"name":"National Institutes of Health, National Institute on Drug Abuse","award":["UG1 DA015831"],"award-info":[{"award-number":["UG1 DA015831"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Stat Methods Med Res"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:p> Conventional approaches for handling missingness in substance use disorder trials commonly rely upon a single deterministic \u201cworst value\u201d imputation that posits a perfect relationship between missingness and drug use (\u201cmissing value\u2009=\u2009presumed drug use\u201d); this yields biased estimates of treatment effects and their standard errors. Instead, deterministic imputations should be replaced by probabilistic versions that encode researchers prior beliefs that those with missing data are more likely to be using drugs at those occasions. Motivated by this problem, we present a method for handling non-monotone missing binary data in longitudinal studies. Specifically, we consider a joint model that combines a not missing at random (NMAR) selection model with a generalized linear mixed model for longitudinal binary data. The selection model links the distribution of a missing outcome to the corresponding distribution of the outcome for those observed at that occasion via a fixed and known sensitivity parameter. The mixed model for longitudinal binary data assumes the random effects have bridge distributions; the latter yields regression parameters that have both subject-specific and marginal interpretations. This approach is completely transparent about what is being assumed about missing data and can be used as the basis for sensitivity analysis. <\/jats:p>","DOI":"10.1177\/0962280218794725","type":"journal-article","created":{"date-parts":[[2018,8,27]],"date-time":"2018-08-27T10:16:56Z","timestamp":1535365016000},"page":"3057-3073","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Sensitivity analysis for non-monotone missing binary data in longitudinal studies: Application to the NIDA collaborative cocaine treatment study"],"prefix":"10.1177","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2265-8810","authenticated-orcid":false,"given":"Garrett M","family":"Fitzmaurice","sequence":"first","affiliation":[{"name":"Division of Alcohol and Drug Abuse, McLean Hospital, Belmont, MA, USA"},{"name":"Department of Psychiatry, Harvard Medical School, Boston, MA, 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