{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T03:25:22Z","timestamp":1793071522036,"version":"4.5.0"},"reference-count":29,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T00:00:00Z","timestamp":1733788800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["Intramural Research Program"],"award-info":[{"award-number":["Intramural Research Program"]}],"id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Stat Methods Med Res"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>Youden index, a linear function of sensitivity and specificity, provides a direct measurement of the highest diagnostic accuracy achievable by a biomarker. It is maximized at the cut-off point that optimizes the biomarker\u2019s overall classification rate while assigning equal weight to sensitivity and specificity. In this paper, we consider the problem of estimating the Youden index when only group-tested data are available. The unavailability of individual disease statuses poses a challenge, especially when there is differential false positives and negatives in disease screening. We propose both parametric and nonparametric procedures for estimation of the Youden index, and exemplify our methods by utilizing data from the National Health and Nutrition Examination Survey (NHANES) to evaluate the diagnostic ability of monocyte for predicting chlamydia.<\/jats:p>","DOI":"10.1177\/09622802241295319","type":"journal-article","created":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T02:45:07Z","timestamp":1733885107000},"page":"45-54","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Youden index estimation based on group-tested data"],"prefix":"10.1177","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0625-5189","authenticated-orcid":false,"given":"Jin","family":"Yang","sequence":"first","affiliation":[{"name":"National Institute of Child Health and Human Development, Bethesda, Maryland, United 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