{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T18:50:21Z","timestamp":1792349421419,"version":"4.4.0"},"reference-count":26,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:00:00Z","timestamp":1792022400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100004744","name":"Innoviris","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004744","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Stat Methods Med Res"],"abstract":"<jats:p>\n                    In clinical trials, the comparison between treatment arms of a measurement is often complicated by an event such as death or progression that can make this measurement irrelevant or difficult to perform. In this article, an approach is proposed to compare treatment arms using the net treatment benefit or the win ratio. A more favorable outcome (win) for the experimental arm is defined as the event of (1) a longer time to event for a patient in the experimental arm compared to a patient from the control arm until a prespecified restriction time\n                    <jats:inline-formula>\n                      <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" display=\"inline\" overflow=\"scroll\">\n                        <mml:mi>\u03f5<\/mml:mi>\n                      <\/mml:math>\n                    <\/jats:inline-formula>\n                    or (2) a more favorable outcome with respect to the measurement during follow-up for a patient from the experimental arm and the time to event greater than\n                    <jats:inline-formula>\n                      <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" display=\"inline\" overflow=\"scroll\">\n                        <mml:mi>\u03f5<\/mml:mi>\n                      <\/mml:math>\n                    <\/jats:inline-formula>\n                    for both patients. An estimator is proposed. A simulation study showed approximately no bias. The methodology is illustrated using a leukemia trial.\n                  <\/jats:p>","DOI":"10.1177\/09622802261498390","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T13:19:18Z","timestamp":1792070358000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Treatment comparisons using a measurement during follow-up and a right-censored time-to-event outcome"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7066-0587","authenticated-orcid":false,"given":"Michal","family":"Kicinski","sequence":"first","affiliation":[{"name":"EORTC Headqaurters"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,10,15]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(19)30790-9"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0258(19980315\/15)17:5\/7<711::AID-SIM816>3.0.CO;2-H"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/sim.70104"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/sim.3923"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehr352"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1201\/9781003390855"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(23)00273-9"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2023023625"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4780111305"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.2202\/1557-4679.1286"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1080\/10543406.2020.1757692"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1177\/09622802211037067"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1177\/0962280216658320"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/bimj.202000001"},{"key":"e_1_3_3_16_2","volume-title":"Restricted GPC for univariate and multivariate settings. In: Handbook of generalized pairwise comparisons","author":"De Backer M","year":"2015","unstructured":"De Backer M, Kicinski M. Restricted GPC for univariate and multivariate settings. In: Handbook of generalized pairwise comparisons. Chapman and Hall\/CRC, 2015."},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0258(19990615)18:11<1341::AID-SIM129>3.0.CO;2-7"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/biom.12225"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/biostatistics\/kxv032"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/biom.12475"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/biomet\/asw026"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/pst.1977"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/biom.12954"},{"key":"e_1_3_3_24_2","first-page":"831","article-title":"The two sample problem with censored data","volume":"4","author":"Efron B.","year":"1967","unstructured":"Efron B. The two sample problem with censored data. 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