{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T01:02:12Z","timestamp":1777510932783,"version":"3.51.4"},"reference-count":41,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2018,6,4]],"date-time":"2018-06-04T00:00:00Z","timestamp":1528070400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cell Transplant"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:p>\n                    The aim of this study was to compare the serum levels of the anti-angiogenic factor endostatin (S-endostatin) as a potential marker of vasculogenesis after autologous cell therapy (ACT) versus percutaneous transluminal angioplasty (PTA) in diabetic patients with critical limb ischemia (CLI). A total of 25 diabetic patients with CLI treated in our foot clinic during the period 2008\u20132014 with ACT generating potential vasculogenesis were consecutively included in the study; 14 diabetic patients with CLI who underwent PTA during the same period were included in a control group in which no vasculogenesis had occurred. S-endostatin was measured before revascularization and at 1, 3, and 6 months after the procedure. The effect of ACT and PTA on tissue ischemia was confirmed by transcutaneous oxygen pressure (TcPO\n                    <jats:sub>2<\/jats:sub>\n                    ) measurement at the same intervals. While S-endostatin levels increased significantly at 1 and 3 months after ACT (both P &lt; 0.001), no significant change of S-endostatin after PTA was observed. Elevation of S-endostatin levels significantly correlated with an increase in TcPO\n                    <jats:sub>2<\/jats:sub>\n                    at 1 month after ACT ( r = 0.557; P &lt; 0.001). Our study showed that endostatin might be a potential marker of vasculogenesis because of its significant increase after ACT in diabetic patients with CLI in contrast to those undergoing PTA. This increase may be a sign of a protective feedback mechanism of this anti-angiogenic factor.\n                  <\/jats:p>","DOI":"10.1177\/0963689718775628","type":"journal-article","created":{"date-parts":[[2018,6,4]],"date-time":"2018-06-04T03:14:40Z","timestamp":1528082080000},"page":"1368-1374","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Difference in Serum Endostatin Levels in Diabetic Patients with Critical Limb Ischemia Treated by Autologous Cell Therapy or Percutaneous Transluminal Angioplasty"],"prefix":"10.1177","volume":"27","author":[{"given":"Andrea","family":"Nemcova","sequence":"first","affiliation":[{"name":"Diabetes Centre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Jirkovska","sequence":"additional","affiliation":[{"name":"Diabetes Centre, Institute for Clinical and 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