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Although porcine female germline stem cells (FGSCs) were identified in the juvenile ovary, no reports described the isolation and purification of FGSCs from the pig at sexual maturity. Here, we isolated, purified, and cultured FGSCs from porcine ovaries at sexual maturity. Furthermore, we established and characterized the porcine FGSC (pFGSC) lines. In addition, we found that pFGSC lines could differentiate into oocytes when injection into tissue grafts, including human ovarian tissues. The results show that FGSCs exist in ovaries of Banna mini-pigs at juvenile and sexually maturity. These findings have implications in animal biotechnology applications and regeneration medicine.<\/jats:p>","DOI":"10.1177\/0963689718784878","type":"journal-article","created":{"date-parts":[[2018,7,11]],"date-time":"2018-07-11T05:01:54Z","timestamp":1531285314000},"page":"1195-1202","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":30,"title":["Characteristics of Female Germline Stem Cells from Porcine Ovaries at Sexual Maturity"],"prefix":"10.1177","volume":"27","author":[{"given":"Lin","family":"Hou","sequence":"first","affiliation":[{"name":"Key Laboratory for the Genetics of Developmental, Neuropsychiatric Disorders (Ministry of Education), Bio-X Institutes, Shanghai Jiao Tong University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory for the Genetics of Developmental, Neuropsychiatric Disorders 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