{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T02:33:49Z","timestamp":1790044429650,"version":"4.0.1"},"reference-count":26,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2019,3,27]],"date-time":"2019-03-27T00:00:00Z","timestamp":1553644800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81200614"],"award-info":[{"award-number":["81200614"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cell Transplant"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:p>We first compared long-term clinical outcomes in treating critical limb ischemia (CLI) and foot ulcer in patients with diabetes between autologous bone marrow mesenchymal stem cell (BMMSC) and bone-marrow-derived mononuclear cell (BMMNC) transplants. Forty-one patients were enrolled and followed up for 3 years. They received an 18-day standard treatment before stem cell transplantation. Patients with bilateral CLI and foot ulcer were injected intramuscularly or basally with BMMSC, BMMNC, or normal saline (NS). Cox model analysis showed significant differences in the hazard ratio (HR) for amputation with treatment by BMMSC (HR 0.21 [95% CI (0.05, 0.95)], P = 0.043), infection of foot (HR 5.30 [95% CI (1.89, 14.92)], P = 0.002), and age \u226564 (HR 3.01 [95% CI (1.11, 8.15)], P = 0.030), but no significant differences by BMMNC at 9 months after transplantation. Regarding ulcer healing and recurrence rate, the BMMSC group demonstrated a significant difference from the NS group during the 3\u20136 months after transplantation or healing, but the BMMNC group did not. This trial suggests that, compared with BMMNC treatment, BMMSC treatment leads to a longer time of limb salvage and blood flow improvement, and, when compared with conventional therapy, it can promote limb blood flow and ulcerative healing, and reduce ulcer recurrence and amputation within 9 months.<\/jats:p>","DOI":"10.1177\/0963689719835177","type":"journal-article","created":{"date-parts":[[2019,3,28]],"date-time":"2019-03-28T01:23:16Z","timestamp":1553736196000},"page":"645-652","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":54,"title":["Long-Term Outcomes of BMMSC Compared with BMMNC for Treatment of Critical Limb Ischemia and Foot Ulcer in Patients with Diabetes"],"prefix":"10.1177","volume":"28","author":[{"given":"Debin","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, PR China"},{"name":"Department of Endocrinology and Metabolism, Southwest Hospital, Third Military Medical University, Chongqing, PR China"},{"name":"* All three authors contributed equally to the study of this article."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youzhao","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Banan People\u2019s Hospital of Chongqing, PR China"},{"name":"* All three authors contributed equally to the study of this article."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wuquan","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Chongqing Emergency Medical Center (Chongqing Fourth People\u2019s Hospital), Chongqing, PR China"},{"name":"* All three authors contributed equally to the study of this article."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Chongqing Emergency Medical Center (Chongqing Fourth People\u2019s Hospital), Chongqing, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziwen","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Southwest Hospital, Third Military Medical University, Chongqing, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinan","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Southwest Hospital, Third Military Medical University, Chongqing, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Southwest Hospital, Third Military 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