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During that year, the use of a newly developed gene-editing tool, the CRISPR-Cas9 system, started to skyrocket. Although scientists unraveled the use of \u201cclustered regularly interspaced short palindromic repeats\u201d (CRISPR) and its associated genes from the Cas family as an evolved mechanism of some bacterial and archaeal genomes to protect themselves from being hijacked by invasive viral genes, its use as a therapeutic tool was not fully appreciated until further research revealed how this system operated and how it might be developed technologically to manipulate genes of any species. By 2015, this technology had exploded to the point that close to 2,000 papers that used this technology were published during that year alone.<\/jats:p>","DOI":"10.1177\/0963689719840662","type":"journal-article","created":{"date-parts":[[2019,4,5]],"date-time":"2019-04-05T01:39:09Z","timestamp":1554428349000},"page":"460-463","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Silencing of the Mutant Huntingtin Gene through CRISPR-Cas9 Improves the Mitochondrial Biomarkers in an In Vitro Model of Huntington\u2019s Disease"],"prefix":"10.1177","volume":"28","author":[{"given":"Gary L.","family":"Dunbar","sequence":"first","affiliation":[{"name":"Field Neurosciences Institute Laboratory for Restorative Neurology, Central Michigan University, Mt. Pleasant, MI, USA"},{"name":"Program in Neuroscience, Central Michigan University, Mt. 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