{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T07:11:03Z","timestamp":1779347463268,"version":"3.51.4"},"reference-count":40,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"JDRF","award":["3-SRA-2016-255-S-B"],"award-info":[{"award-number":["3-SRA-2016-255-S-B"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cell Transplant"],"published-print":{"date-parts":[[2020,1,1]]},"abstract":"<jats:p>\n                    Medical devices for cell therapy can be improved through prevascularization. In this work we study the vascularization of a porous polymer device, previously used by our group for pancreatic islet transplantation with results indicating improved glycemic control. Oxygen partial pressure within such devices was monitored non-invasively using an optical technique. Oxygen-sensitive tubes were fabricated and placed inside devices prior to subcutaneous implantation in nude mice. We tested the hypothesis that vascularization will be enhanced by administration of the pro-angiogenic factor hydrogen sulfide (H\n                    <jats:sub>2<\/jats:sub>\n                    S). We found that oxygen dynamics were unique to each implant and that the administration of H\n                    <jats:sub>2<\/jats:sub>\n                    S does not result in significant changes in perfusion of the devices as compared with control. These observations suggest that vascular perfusion and density are not necessarily correlated, and that the rate of vascularization was not enhanced by the pro-angiogenic agent.\n                  <\/jats:p>","DOI":"10.1177\/0963689719893936","type":"journal-article","created":{"date-parts":[[2020,2,6]],"date-time":"2020-02-06T02:59:02Z","timestamp":1580957942000},"page":"096368971989393","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Non-Invasive Monitoring of Oxygen Tension and Oxygen Transport Inside Subcutaneous Devices After H\n                    <sub>2<\/sub>\n                    S Treatment"],"prefix":"10.1177","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5702-3922","authenticated-orcid":false,"given":"Avid","family":"Najdahmadi","sequence":"first","affiliation":[{"name":"Department of Materials Science and Engineering, University of California Irvine, Irvine, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra M.","family":"Smink","sequence":"additional","affiliation":[{"name":"Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"de Vos","sequence":"additional","affiliation":[{"name":"Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8553-4287","authenticated-orcid":false,"given":"Jonathan R.T.","family":"Lakey","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, University of California Irvine, Irvine, CA, USA"},{"name":"Department of Surgery, University of California Irvine, Irvine, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elliot","family":"Botvinick","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering, University of California Irvine, Irvine, CA, USA"},{"name":"Department of Biomedical Engineering, University of California Irvine, Irvine, CA, USA"},{"name":"Department of Surgery, University of California Irvine, Irvine, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,2,5]]},"reference":[{"key":"bibr1-0963689719893936","doi-asserted-by":"publisher","DOI":"10.1038\/scientificamerican0499-86"},{"key":"bibr2-0963689719893936","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2012.09.010"},{"key":"bibr3-0963689719893936","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200007273430401"},{"key":"bibr4-0963689719893936","doi-asserted-by":"publisher","DOI":"10.1097\/01.mjt.0000178767.67857.63"},{"issue":"1","key":"bibr5-0963689719893936","first-page":"71","volume":"72","author":"Gillard P","year":"2010","journal-title":"Verh K Acad Geneeskd Belg"},{"key":"bibr6-0963689719893936","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa052187"},{"key":"bibr7-0963689719893936","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200002103420603"},{"key":"bibr8-0963689719893936","doi-asserted-by":"publisher","DOI":"10.1177\/0141076816636369"},{"key":"bibr9-0963689719893936","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000157321.55375.86"},{"key":"bibr10-0963689719893936","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2005.00957.x"},{"key":"bibr11-0963689719893936","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199606150-00001"},{"key":"bibr12-0963689719893936","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000203858.41105.88"},{"key":"bibr13-0963689719893936","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-001-0729-x"},{"key":"bibr14-0963689719893936","doi-asserted-by":"publisher","DOI":"10.1557\/adv.2018.455"},{"key":"bibr15-0963689719893936","unstructured":"Najdahmadi A, Lakey JR, Botvinick E. 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