{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:56:53Z","timestamp":1777510613036,"version":"3.51.4"},"reference-count":34,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"the Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81470341"],"award-info":[{"award-number":["81470341"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cell Transplant"],"published-print":{"date-parts":[[2020,1,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Chimeric antigen receptor T cells (CAR-Ts) constitute a novel therapeutic strategy for relapsed\/refractory B-cell malignancies. CAR-T therapy has been extensively applied in the clinical setting; however, few systematic studies have evaluated the cost of CAR-T treatment. This study was conducted to evaluate the total cost and cost structure of CAR-T therapy and identify potential risk factors leading to increased costs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We identified the associated risk factors in 89 patients in a phase 1\/2 study. The cohort included patients with acute lymphoblastic leukemia (ALL, n = 55) and non-Hodgkin\u2019s lymphoma (NHL, n = 34).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Overall, the treatment of the ALL cohort was costlier than that of the NHL cohort ( P &lt; 0.001). Furthermore, in the ALL cohort, it was costlier to treat patients with a high tumor burden ( P &lt; 0.001), high cytokine release syndrome (CRS) grade ( P &lt; 0.001), and complications of infection after CAR-T cell infusion (CTI) in the whole cohort ( P = 0.013) than patients with a low tumor burden, with low CRS grade, and without infection, respectively. CRS grade and length of stay ( P \u2264 0.005) were independent risk factors associated with the total cost in both the ALL and NHL cohorts during CAR-T therapy. A high tumor burden, duration of fever, and treatment with tocilizumab were independent risk factors associated with the total cost in the ALL cohort ( P &lt; 0.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>CAR-T treatment should be extended to patients with a low tumor burden or patients in a state of complete remission, and a corticosteroid approach, as opposed to tocilizumab, may reduce costs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0963689720919434","type":"journal-article","created":{"date-parts":[[2020,4,21]],"date-time":"2020-04-21T08:03:14Z","timestamp":1587456194000},"page":"096368972091943","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":21,"title":["Factors Associated with Costs in Chimeric Antigen Receptor T-Cell Therapy for Patients with Relapsed\/Refractory B-Cell Malignancies"],"prefix":"10.1177","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3140-4289","authenticated-orcid":false,"given":"Feng","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Hematology, Zhoushan Hospital, China"},{"name":"Bone Marrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China"},{"name":"Both the authors contributed equally to this work"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoqing","family":"Wei","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China"},{"name":"Zhejiang Province Engineering Laboratory for Stem Cell and Immunity Therapy, Hangzhou, China"},{"name":"Institute of Hematology, Zhejiang University, Hangzhou, China"},{"name":"Both the authors contributed equally to this work"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingming","family":"Zhang","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China"},{"name":"Zhejiang Province Engineering Laboratory for Stem Cell and Immunity Therapy, Hangzhou, China"},{"name":"Institute of Hematology, Zhejiang University, Hangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Houli","family":"Zhao","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China"},{"name":"Zhejiang Province Engineering Laboratory for Stem Cell and Immunity Therapy, Hangzhou, China"},{"name":"Institute of Hematology, Zhejiang University, Hangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjun","family":"Wu","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China"},{"name":"Zhejiang Province Engineering Laboratory for Stem Cell and Immunity Therapy, Hangzhou, China"},{"name":"Institute of Hematology, Zhejiang University, Hangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luxin","family":"Yang","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China"},{"name":"Zhejiang Province Engineering Laboratory for Stem Cell and Immunity Therapy, Hangzhou, China"},{"name":"Institute of Hematology, Zhejiang University, Hangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongxian","family":"Hu","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China"},{"name":"Zhejiang Province Engineering Laboratory for Stem Cell and Immunity Therapy, Hangzhou, China"},{"name":"Institute of Hematology, Zhejiang University, Hangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"He","family":"Huang","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China"},{"name":"Zhejiang Province Engineering Laboratory for Stem Cell and Immunity Therapy, Hangzhou, China"},{"name":"Institute of Hematology, Zhejiang University, Hangzhou, 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