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The disorders include bradykinesia and rigidity commonly seen in Parkinsonism disease and additional signs such as autonomic dysfunction, ataxia, or dementia. In clinical treatments, MSA poorly responds to levodopa, the drug used to remedy Parkinsonism disease. The exact cause of MSA is still unknown, and exploring a therapeutic solution to MSA remains critical. A transgenic mouse model was established to study the feasibility of human adipose-derived stem cell (ADSC) therapy in vivo. The human ADSCs were transplanted into the striatum of transgenic mice via intracerebral injection. As compared with sham control, we reported significantly enhanced rotarod performance of transgenic mice treated with ADSC at an effective dose, 2 \u00d7 10\n                    <jats:sup>5<\/jats:sup>\n                    ADSCs\/mouse. Our ex vivo feasibility study supported that intracerebral transplantation of ADSC might alleviate striatal degeneration in MSA transgenic mouse model by improving the nigrostriatal pathway for dopamine, activating autophagy for \u03b1-synuclein clearance, decreasing inflammatory signal, and further cell apoptosis, improving myelination and cell survival at caudate-putamen.\n                  <\/jats:p>","DOI":"10.1177\/0963689720960185","type":"journal-article","created":{"date-parts":[[2020,10,8]],"date-time":"2020-10-08T02:46:27Z","timestamp":1602125187000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Transplantation of Adipose-Derived Stem Cells Alleviates Striatal Degeneration in a Transgenic Mouse Model for Multiple System Atrophy"],"prefix":"10.1177","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8290-8458","authenticated-orcid":false,"given":"Christine","family":"Chang","sequence":"first","affiliation":[{"name":"National Dong Hwa University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jen-Wei","family":"Liu","sequence":"additional","affiliation":[{"name":"National Dong Hwa University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo Cheng","family":"Chen","sequence":"additional","affiliation":[{"name":"National Dong Hwa University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhe Sheng","family":"Jiang","sequence":"additional","affiliation":[{"name":"National Dong Hwa University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi Tang","family":"Tu","sequence":"additional","affiliation":[{"name":"Taiwan Mitochondrion Applied Technology Co., Ltd., Hsinchu, Taiwan, R.O.C"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Che Hung","family":"Su","sequence":"additional","affiliation":[{"name":"National Dong Hwa University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsin Han","family":"Yang","sequence":"additional","affiliation":[{"name":"National Dong Hwa University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zong Qi","family":"Liu","sequence":"additional","affiliation":[{"name":"National Dong Hwa University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu Chen","family":"Deng","sequence":"additional","affiliation":[{"name":"National Dong Hwa University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chih Yu","family":"Chen","sequence":"additional","affiliation":[{"name":"National Dong Hwa University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6611-9440","authenticated-orcid":false,"given":"Sheng-Tzung","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Buddhist Tzu Chi General Hospital, Hualien, Taiwan, R.O.C"},{"name":"Institute of Medical Science, Tzu Chi University, Hualien, Taiwan, R.O.C"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinn Zong","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Buddhist Tzu Chi General Hospital, Hualien, Taiwan, R.O.C"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tzyy-Wen","family":"Chiou","sequence":"additional","affiliation":[{"name":"National Dong Hwa University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,10,7]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1080\/14737175.2017.1392239"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-017-1772-0"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2017.09.016"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2012-302500"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1519\/00139143-200831020-00007"},{"issue":"1","key":"e_1_3_3_7_2","first-page":"73","article-title":"A 65-year-old man with rigid-bradykinetic Parkinsonism, vertical gaze palsy, difficulty of eye-lid opening, and marked pseudo-bulbar palsy [in Japanese]","volume":"57","author":"Noda K","year":"2005","unstructured":"Noda K, Kobayashi T, Matsuoka S, Takanashi M, Kanazawa A, Mizuno Y. 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