{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T10:05:37Z","timestamp":1790849137594,"version":"4.1.0"},"reference-count":42,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","award":["HI14C1135"],"award-info":[{"award-number":["HI14C1135"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cell Transplant"],"published-print":{"date-parts":[[2020,1,1]]},"abstract":"<jats:p>Islet transplantation has emerged as a promising treatment for type 1 diabetes mellitus. Liraglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist, protects beta cells after islet transplantation by improving glycemic control through several mechanisms. In this study, we compared the effects of local pretreatment and systemic treatment with liraglutide on islet transplantation in a diabetic mouse model. Streptozotocin (STZ)-induced diabetic C57BL\/6 mice were transplanted with syngeneic islets under the kidney capsule. Isolated islets were either locally treated with liraglutide before transplantation or mice were treated systemically by intraperitoneal injection after islet transplantation. Local pretreatment of islets with liraglutide was more effective in increasing body weight, decreasing hemoglobin A1c levels, and lowering blood glucose levels in STZ-diabetic mice transplanted with islets. Local pretreatment was also more effective in increasing insulin secretion and islet survival in STZ-diabetic mice. Histological analysis of the transplantation site revealed fewer apoptotic cells following local pretreatment compared with systemic injection of liraglutide. These findings indicate that liraglutide administered once locally before transplantation might have superior effects on islet preservation than systemic administration.<\/jats:p>","DOI":"10.1177\/0963689720971245","type":"journal-article","created":{"date-parts":[[2020,11,11]],"date-time":"2020-11-11T02:17:07Z","timestamp":1605061027000},"page":"096368972097124","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Comparison of the Effects of Liraglutide on Islet Graft Survival Between Local and Systemic Delivery"],"prefix":"10.1177","volume":"29","author":[{"given":"Song Mi","family":"Lee","sequence":"first","affiliation":[{"name":"College of Pharmacy and Gachon Institute Pharmaceutical Science, Gachon University, Yeonsu-gu, Incheon, Korea"},{"name":"Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Yeonsu-gu, Incheon, Korea"},{"name":"Both the authors contributed equally to this article"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donghee","family":"Kim","sequence":"additional","affiliation":[{"name":"Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Yeonsu-gu, Incheon, Korea"},{"name":"Both the authors contributed equally to this article"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung Min","family":"Kwak","sequence":"additional","affiliation":[{"name":"Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Yeonsu-gu, Incheon, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phyu Phyu","family":"Khin","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Gachon Institute Pharmaceutical Science, Gachon University, Yeonsu-gu, Incheon, Korea"},{"name":"Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Yeonsu-gu, Incheon, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oh Kyung","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, Gachon University Gil Medical Center, Namdong-gu, Incheon, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwang-Won","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Gachon University Gil Medical Center, Namdong-gu, Incheon, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byung-Joon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Gachon University Gil Medical Center, Namdong-gu, Incheon, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1166-4932","authenticated-orcid":false,"given":"Hee-Sook","family":"Jun","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Gachon Institute Pharmaceutical Science, Gachon University, Yeonsu-gu, Incheon, Korea"},{"name":"Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Yeonsu-gu, Incheon, Korea"},{"name":"Gil Medical Research Institute, Gil Hospital, Namdong-gu, Incheon, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,11,10]]},"reference":[{"issue":"3","key":"bibr1-0963689720971245","doi-asserted-by":"crossref","first-page":"380","DOI":"10.4239\/wjd.v6.i3.380","volume":"6","author":"Simmons KM","year":"2015","journal-title":"World J Diabetes"},{"key":"bibr2-0963689720971245","doi-asserted-by":"publisher","DOI":"10.1007\/s00592-015-0735-y"},{"key":"bibr3-0963689720971245","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2008.02353.x"},{"key":"bibr4-0963689720971245","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2016.178"},{"key":"bibr5-0963689720971245","doi-asserted-by":"publisher","DOI":"10.1111\/xen.12196"},{"issue":"1","key":"bibr6-0963689720971245","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1111\/j.1464-5491.2011.03433.x","volume":"29","author":"Godfrey KJ","year":"2012","journal-title":"Diabet Med"},{"key":"bibr7-0963689720971245","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcyt.2013.05.008"},{"issue":"4","key":"bibr8-0963689720971245","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1016\/j.transproceed.2013.11.074","volume":"46","author":"Jo YH","year":"2014","journal-title":"Transplant Proc"},{"key":"bibr9-0963689720971245","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-12472-3"},{"issue":"9","key":"bibr10-0963689720971245","doi-asserted-by":"crossref","first-page":"2419","DOI":"10.2337\/db06-0484","volume":"55","author":"Evgenov NV","year":"2006","journal-title":"Diabetes"},{"issue":"11","key":"bibr11-0963689720971245","doi-asserted-by":"crossref","first-page":"3202","DOI":"10.2337\/diabetes.51.11.3202","volume":"51","author":"Makhlouf L","year":"2002","journal-title":"Diabetes"},{"issue":"5","key":"bibr12-0963689720971245","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1210\/er.2008-0006","volume":"29","author":"Huang X","year":"2008","journal-title":"Endocr Rev"},{"issue":"5","key":"bibr13-0963689720971245","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1210\/en.2008-1116","volume":"150","author":"Emamaullee JA","year":"2009","journal-title":"Endocrinology"},{"key":"bibr14-0963689720971245","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00034.2006"},{"key":"bibr15-0963689720971245","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.13852"},{"key":"bibr16-0963689720971245","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2006.11.007"},{"issue":"24","key":"bibr17-0963689720971245","doi-asserted-by":"crossref","first-page":"3443","DOI":"10.1111\/bph.13575","volume":"173","author":"Langlois A","year":"2016","journal-title":"Br J Pharmacol"},{"issue":"3","key":"bibr18-0963689720971245","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1111\/j.1432-2277.2009.00984.x","volume":"23","author":"Toso C","year":"2010","journal-title":"Transpl Int"},{"issue":"3","key":"bibr19-0963689720971245","doi-asserted-by":"crossref","first-page":"e0147068","DOI":"10.1371\/journal.pone.0147068","volume":"11","author":"Langlois A","year":"2016","journal-title":"PLoS One"},{"issue":"3","key":"bibr20-0963689720971245","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1007\/s13346-018-0484-x","volume":"8","author":"Lew B","year":"2018","journal-title":"Drug Deliv Transl Res"},{"key":"bibr21-0963689720971245","doi-asserted-by":"publisher","DOI":"10.2337\/diab.46.7.1120"},{"issue":"10","key":"bibr22-0963689720971245","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1172\/JCI5241","volume":"103","author":"Bleich D","year":"1999","journal-title":"J Clin Invest"},{"key":"bibr23-0963689720971245","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2008.08.155"},{"issue":"10","key":"bibr24-0963689720971245","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1097\/TP.0000000000000388","volume":"98","author":"Dao LT","year":"2014","journal-title":"Transplantation"},{"issue":"3","key":"bibr25-0963689720971245","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.ymthe.2004.01.008","volume":"9","author":"Lu Y","year":"2004","journal-title":"Mol Ther"},{"key":"bibr26-0963689720971245","doi-asserted-by":"publisher","DOI":"10.1586\/1744666X.2015.978291"},{"key":"bibr27-0963689720971245","doi-asserted-by":"crossref","first-page":"108674","DOI":"10.1016\/j.biopha.2019.108674","volume":"112","author":"Kaviani M","year":"2019","journal-title":"Biomed Pharmacother"},{"issue":"1","key":"bibr28-0963689720971245","doi-asserted-by":"crossref","first-page":"11701","DOI":"10.1038\/s41598-019-48262-6","volume":"9","author":"Keshtkar S","year":"2019","journal-title":"Sci Rep"},{"key":"bibr29-0963689720971245","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2012.02.028"},{"key":"bibr30-0963689720971245","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2011.09.051"},{"key":"bibr31-0963689720971245","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4914(02)02381-X"},{"issue":"9","key":"bibr32-0963689720971245","doi-asserted-by":"crossref","first-page":"2453","DOI":"10.1007\/s11095-014-1340-4","volume":"31","author":"Haque MR","year":"2014","journal-title":"Pharm Res"},{"key":"bibr33-0963689720971245","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.6b07897"},{"key":"bibr34-0963689720971245","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-013-0402-z"},{"issue":"9","key":"bibr35-0963689720971245","doi-asserted-by":"crossref","first-page":"4322","DOI":"10.1210\/en.2008-0501","volume":"149","author":"Merani S","year":"2008","journal-title":"Endocrinology"},{"key":"bibr36-0963689720971245","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2016.01.009"},{"key":"bibr37-0963689720971245","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000000864"},{"key":"bibr38-0963689720971245","doi-asserted-by":"publisher","DOI":"10.3727\/096368913X673469"},{"issue":"47","key":"bibr39-0963689720971245","doi-asserted-by":"crossref","first-page":"6347","DOI":"10.3748\/wjg.v13.i47.6347","volume":"13","author":"Meloche RM","year":"2007","journal-title":"World J Gastroenterol"},{"key":"bibr40-0963689720971245","doi-asserted-by":"crossref","first-page":"382","DOI":"10.3389\/fendo.2017.00382","volume":"8","author":"Kim D","year":"2017","journal-title":"Front Endocrinol (Lausanne)"},{"key":"bibr41-0963689720971245","doi-asserted-by":"publisher","DOI":"10.1162\/1535350042973508"},{"key":"bibr42-0963689720971245","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181f1db5d"}],"container-title":["Cell Transplantation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0963689720971245","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0963689720971245","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0963689720971245","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:38:19Z","timestamp":1777390699000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.sagepub.com\/doi\/10.1177\/0963689720971245"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,1]]},"references-count":42,"alternative-id":["10.1177\/0963689720971245"],"URL":"https:\/\/doi.org\/10.1177\/0963689720971245","relation":{},"ISSN":["0963-6897","1555-3892"],"issn-type":[{"value":"0963-6897","type":"print"},{"value":"1555-3892","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,1]]}}}