{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T16:04:23Z","timestamp":1785600263515,"version":"3.56.0"},"reference-count":20,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81970535"],"award-info":[{"award-number":["81970535"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cell Transplant"],"published-print":{"date-parts":[[2021,1,1]]},"abstract":"<jats:p>\n                    Transfer of exogenous macrophages represents an alternative technique to treat liver fibrosis. At present, bone marrow-derived monocytes and stem cells are the main sources for exogenous macrophages. Kupffer cells (KCs) are the resident macrophages in the liver and play a critical role in the liver homeostasis and diseases. It is unclear whether infusion of KCs can treat liver fibrosis. In this study, we observed that granulocyte-macrophage colony stimulating factor (GM-CSF) could improve the purity of cultured KCs and significantly up-regulate the expression of Cluster of Differentiation 11b (CD11b). The most important point is that GM-CSF could significantly promote the proliferation of KCs in vitro. KCs expanded in vitro still had the potential of M1\/M2 polarization and phagocytosis. Furthermore, infusion of these KCs could ameliorate liver fibrosis induced by carbon tetrachloride (CCl\n                    <jats:sub>4<\/jats:sub>\n                    ) in mice. Together, our results suggest that KCs are likely to be another source for macrophage therapy.\n                  <\/jats:p>","DOI":"10.1177\/09636897211004090","type":"journal-article","created":{"date-parts":[[2021,3,31]],"date-time":"2021-03-31T03:39:41Z","timestamp":1617161981000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Infusion of Kupffer Cells Expanded in\n                    <i>Vitro<\/i>\n                    Ameliorated Liver Fibrosis in a Murine Model of Liver Injury"],"prefix":"10.1177","volume":"30","author":[{"given":"Weina","family":"Li","sequence":"first","affiliation":[{"name":"School of Basic Medicine, Fourth Military Medical University, Xi\u2019an, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8368-5030","authenticated-orcid":false,"given":"Fei","family":"He","sequence":"additional","affiliation":[{"name":"School of Medicine, Faculty of Life Science and Medicine, Northwest University, Xi\u2019an, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,3,31]]},"reference":[{"key":"bibr1-09636897211004090","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-014-0145-y"},{"key":"bibr2-09636897211004090","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-020-00372-7"},{"key":"bibr3-09636897211004090","doi-asserted-by":"publisher","DOI":"10.1055\/s-0035-1550057"},{"key":"bibr4-09636897211004090","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29867"},{"key":"bibr5-09636897211004090","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-020-00558-8"},{"key":"bibr6-09636897211004090","doi-asserted-by":"publisher","DOI":"10.1055\/s-0039-1688502"},{"key":"bibr7-09636897211004090","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcyt.2015.07.016"},{"key":"bibr8-09636897211004090","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24315"},{"key":"bibr9-09636897211004090","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.05.022"},{"key":"bibr10-09636897211004090","doi-asserted-by":"publisher","DOI":"10.1038\/s41536-017-0017-0"},{"key":"bibr11-09636897211004090","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2006.01342.x"},{"key":"bibr12-09636897211004090","doi-asserted-by":"publisher","DOI":"10.1038\/nature13989"},{"key":"bibr13-09636897211004090","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.12.001"},{"key":"bibr14-09636897211004090","doi-asserted-by":"publisher","DOI":"10.1016\/j.rinim.2014.08.001"},{"key":"bibr15-09636897211004090","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0070832"},{"key":"bibr16-09636897211004090","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.201100157"},{"key":"bibr17-09636897211004090","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-10-0269"},{"key":"bibr18-09636897211004090","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-15-2019"},{"key":"bibr19-09636897211004090","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1400574"},{"key":"bibr20-09636897211004090","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2015.11.002"}],"container-title":["Cell Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09636897211004090","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/09636897211004090","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09636897211004090","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:38:39Z","timestamp":1777390719000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/09636897211004090"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,1]]},"references-count":20,"alternative-id":["10.1177\/09636897211004090"],"URL":"https:\/\/doi.org\/10.1177\/09636897211004090","relation":{},"ISSN":["0963-6897","1555-3892"],"issn-type":[{"value":"0963-6897","type":"print"},{"value":"1555-3892","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,1]]},"article-number":"09636897211004090"}}