{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T15:37:30Z","timestamp":1784043450853,"version":"3.55.0"},"reference-count":21,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cell Transplant"],"published-print":{"date-parts":[[2021,1,1]]},"abstract":"<jats:p>Stem cell therapy has been explored for the treatment of cerebral stroke. Several types of stem cells have been investigated to ensure the safety and efficacy in clinical trials.<\/jats:p>\n                  <jats:p>\n                    Cryopreserved umbilical cord blood (UCB) mononuclear cells (MNCs) obtained from healthy donors have a more stabilized quality, thereby ensuring a successful therapy. A phase I study was conducted on patients aged 45\u201380 years who sustained acute ischemic stroke. An UCB unit was obtained from a public cord blood bank based on ABO\/Rh blood type, HLA matching score (6\/6), and cell dose (total MNC count of 0.5\u20135 \u00d7 10\n                    <jats:sup>7<\/jats:sup>\n                    cells\/kg). In addition, to facilitate blood brain barrier penetration of UCB, 4 doses of 100 mL mannitol was administered intravenously after 30 min after UCB transplantation and every 4 h thereafter. The primary outcomes were the number of disease (GVHD) within 100 days after transfusion. The secondary outcomes were changes in the National Institutes of Health Stroke Scale (NIHSS), Barthel index, and Berg Balance Scale scores. A 46-year-old male patient with identical ABO\/Rh blood type, HLA matching score of 6\/6, and MNC count of 2.63 \u00d7 10\n                    <jats:sup>8<\/jats:sup>\n                    cells\/kg was enrolled. The patient did not present with serious AEs or GVHD during the 12-month study period. The patient\u2019s NIHSS score decreased from 9 to 1. Moreover, the Berg Balance Scale score increased from 0 to 48 and the Barthel index score from 0 to 90. This preliminary study showed that an adult patient with hemiplegia due to ischemic stroke completely recovered within 12 months after receiving allogeneic UCB therapy.\n                  <\/jats:p>","DOI":"10.1177\/09636897211067447","type":"journal-article","created":{"date-parts":[[2021,12,23]],"date-time":"2021-12-23T09:50:10Z","timestamp":1640253010000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":19,"title":["Complete Restoration of Motor Function in Acute Cerebral Stroke Treated with Allogeneic Human Umbilical Cord Blood Monocytes: Preliminary Results of a phase I Clinical Trial"],"prefix":"10.1177","volume":"30","author":[{"given":"Tian-Kuo","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Neurosurgical Unit, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-You","family":"Lu","sequence":"additional","affiliation":[{"name":"Cardiovascular and Mitochondrial Related Disease Research Center, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6611-9440","authenticated-orcid":false,"given":"Sheng-Tzung","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien"},{"name":"College of Medicine, Tzu Chi University, Hualien"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pao-Hui","family":"Tseng","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien"},{"name":"College of Medicine, Tzu Chi University, Hualien"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Chen","family":"Lin","sequence":"additional","affiliation":[{"name":"Bioinnovation Center, Buddhist Tzu Chi Medical Foundation, Hualien"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinn-Zong","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien"},{"name":"College of Medicine, Tzu Chi University, Hualien"},{"name":"Bioinnovation Center, Buddhist Tzu Chi Medical Foundation, Hualien"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas C","family":"Wang","sequence":"additional","affiliation":[{"name":"StemCyte International Ltd, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2347-0411","authenticated-orcid":false,"given":"Chih-Yang","family":"Huang","sequence":"additional","affiliation":[{"name":"Cardiovascular and Mitochondrial Related Disease Research Center, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien"},{"name":"Department of Medical Laboratory Science and Biotechnology, Asia University, Taichung"},{"name":"Graduate Institute of Biomedical Science, China Medical University, Taichung"},{"name":"Center of General Education, Buddhist Tzu Chi Medical Foundation, Tzu Chi University of Science and Technology, Hualien"},{"name":"Department of Medical Research, China Medical University, Hospital, China Medical University, Taichung"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5717-8104","authenticated-orcid":false,"given":"Tsung-Lang","family":"Chiu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien"},{"name":"College of Medicine, Tzu Chi University, Hualien"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,12,23]]},"reference":[{"key":"bibr1-09636897211067447","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2020.00473"},{"key":"bibr2-09636897211067447","doi-asserted-by":"publisher","DOI":"10.1186\/1479-5876-7-97"},{"key":"bibr3-09636897211067447","doi-asserted-by":"publisher","DOI":"10.3727\/096368914X678562"},{"key":"bibr4-09636897211067447","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.13898"},{"key":"bibr5-09636897211067447","doi-asserted-by":"publisher","DOI":"10.1089\/152581603322022990"},{"key":"bibr6-09636897211067447","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2008.0018"},{"key":"bibr7-09636897211067447","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000141681.06735.9b"},{"key":"bibr8-09636897211067447","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2005.14.595"},{"key":"bibr9-09636897211067447","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2006.03.017"},{"key":"bibr10-09636897211067447","doi-asserted-by":"publisher","DOI":"10.1126\/science.1093933"},{"key":"bibr11-09636897211067447","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5728(02)00367-3"},{"key":"bibr12-09636897211067447","doi-asserted-by":"publisher","DOI":"10.1016\/j.aanat.2012.09.003"},{"key":"bibr13-09636897211067447","doi-asserted-by":"publisher","DOI":"10.3727\/096368911X589609"},{"key":"bibr14-09636897211067447","doi-asserted-by":"publisher","DOI":"10.1177\/0963689719854354"},{"key":"bibr15-09636897211067447","doi-asserted-by":"publisher","DOI":"10.1007\/s12975-019-00736-5"},{"key":"bibr16-09636897211067447","doi-asserted-by":"publisher","DOI":"10.1177\/0963689718806846"},{"key":"bibr17-09636897211067447","doi-asserted-by":"publisher","DOI":"10.1002\/sctm.19-0076"},{"key":"bibr18-09636897211067447","doi-asserted-by":"publisher","DOI":"10.1007\/s12975-017-0580-0"},{"key":"bibr19-09636897211067447","doi-asserted-by":"publisher","DOI":"10.3727\/096368916X690971"},{"key":"bibr20-09636897211067447","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2008.00671.x"},{"key":"bibr21-09636897211067447","doi-asserted-by":"publisher","DOI":"10.3727\/096368914X678337"}],"container-title":["Cell 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