{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T01:03:28Z","timestamp":1777511008435,"version":"3.51.4"},"reference-count":30,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"University Medical Center Ljubljana tertiary research grant","award":["TP\/20210122"],"award-info":[{"award-number":["TP\/20210122"]}]},{"name":"Slovenian Research Agency grant","award":["J3-7312-0381"],"award-info":[{"award-number":["J3-7312-0381"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cell Transplant"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>\n                    We investigated the effects of cell therapy on local mechanical dyssynchrony (LMD) in patients with nonischemic dilated cardiomyopathy (NICM). We analyzed electromechanical data of 30 NICM patients undergoing CD34\n                    <jats:sup>+<\/jats:sup>\n                    cell transplantation. All patients underwent bone marrow stimulation; CD34\n                    <jats:sup>+<\/jats:sup>\n                    cells were collected by apheresis and injected transendocardially. At baseline and at 6 months after therapy, we performed electromechanical mapping and measured unipolar voltage (UV) and LMD at cell injection sites. LMD was defined as a temporal difference between global and segmental peak systolic displacement normalized to the average duration of the RR interval. Favorable clinical response was defined as increase in the left ventricular ejection fraction (LVEF) \u22655% between baseline and 6 months. Using paired electromechanical point-by-point analysis, we were able to identify 233 sites of CD34\n                    <jats:sup>+<\/jats:sup>\n                    cell injections in 30 patients. We found no overall differences in local UV between baseline and 6 months (10.7 \u00b1 4.1 mV vs 10.0 \u00b1 3.6 mV, P = 0.42). In contrast, LMD decreased significantly (17 \u00b1 17% at baseline vs 13 \u00b1 12% at 6 months, P = 0.00007). Favorable clinical response at 6 months was found in 19 (63%) patients (group A), and 11 (37%) patients did not respond to cell therapy (group B). At baseline, the two groups did not differ in age, gender, LVEF, or N terminal-pro brain natriuretic peptide (NT-proBNP) levels. Similarly, we found no differences in baseline UV (9.5 \u00b1 2.9 mV in group A vs 8.6 \u00b1 2.4 mV in group B, P = 0.41) or LMD at cell injection sites (17 \u00b1 19% vs 16 \u00b1 14%, P = 0.64). In contrast, at 6 months, we found higher UV in group A (10.0 \u00b1 3.1 mV vs 7.4 \u00b1 1.9 mV in group B, P = 0.04). Furthermore, when compared with group B, patients in group A displayed a significantly lower LMD (11 \u00b1 12% vs 16 \u00b1 10%, P = 0.002). Thus, it appears that favorable clinical effects of cell therapy in NICM patients may be associated with a decrease of LMD at cell injection sites.\n                  <\/jats:p>","DOI":"10.1177\/09636897221080384","type":"journal-article","created":{"date-parts":[[2022,3,23]],"date-time":"2022-03-23T12:29:36Z","timestamp":1648038576000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Transendocardial CD34\n                    <sup>+<\/sup>\n                    Cell Therapy Improves Local Mechanical Dyssynchrony in Patients With Nonischemic Dilated Cardiomyopathy"],"prefix":"10.1177","volume":"31","author":[{"given":"Ne\u017ea","family":"\u017dor\u017e","sequence":"first","affiliation":[{"name":"Advanced Heart Failure and Transplantation Center, Department of Cardiology, University Medical Center Ljubljana, Ljubljana, Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1777-8807","authenticated-orcid":false,"given":"Gregor","family":"Poglajen","sequence":"additional","affiliation":[{"name":"Advanced Heart Failure and Transplantation Center, Department of Cardiology, University Medical Center Ljubljana, Ljubljana, Slovenia"},{"name":"Department of Internal Medicine, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabina","family":"Frljak","sequence":"additional","affiliation":[{"name":"Advanced Heart Failure and Transplantation Center, Department of Cardiology, University Medical Center Ljubljana, Ljubljana, Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivan","family":"Knezevi\u010d","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, University Medical Center Ljubljana, Ljubljana, Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bojan","family":"Vrtovec","sequence":"additional","affiliation":[{"name":"Advanced Heart Failure and Transplantation Center, Department of Cardiology, University Medical Center Ljubljana, Ljubljana, Slovenia"},{"name":"Department of Internal Medicine, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,3,23]]},"reference":[{"key":"bibr1-09636897221080384","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000455"},{"key":"bibr2-09636897221080384","volume":"18","author":"Merlo M","year":"2018","journal-title":"Int J Cardiol Heart Vasc"},{"key":"bibr3-09636897221080384","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.09.027"},{"key":"bibr4-09636897221080384","doi-asserted-by":"publisher","DOI":"10.1016\/j.ehj.2003.09.030"},{"key":"bibr5-09636897221080384","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)02569-X"},{"key":"bibr6-09636897221080384","doi-asserted-by":"publisher","DOI":"10.1038\/srep20711"},{"key":"bibr7-09636897221080384","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2009.12.022"},{"issue":"5","key":"bibr8-09636897221080384","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.109.855023","volume":"2","author":"Fischer-Rasokat U","year":"2009","journal-title":"Circ Heart Fail"},{"key":"bibr9-09636897221080384","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.11.070"},{"key":"bibr10-09636897221080384","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.112.276519"},{"key":"bibr11-09636897221080384","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.000230"},{"key":"bibr12-09636897221080384","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv390"},{"key":"bibr13-09636897221080384","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.11.009"},{"key":"bibr14-09636897221080384","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.108.176826"},{"key":"bibr15-09636897221080384","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.114.001614"},{"key":"bibr16-09636897221080384","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv727"},{"key":"bibr17-09636897221080384","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.05.011"},{"key":"bibr18-09636897221080384","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1994.tb08321.x"},{"key":"bibr19-09636897221080384","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.08.977"},{"issue":"3","key":"bibr20-09636897221080384","volume":"16","author":"Lang RM","year":"2015","journal-title":"Imaging"},{"key":"bibr21-09636897221080384","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-82793-1"},{"key":"bibr22-09636897221080384","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euz346"},{"key":"bibr23-09636897221080384","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)62023-7"},{"key":"bibr24-09636897221080384","doi-asserted-by":"publisher","DOI":"10.1007\/s001470100339"},{"key":"bibr25-09636897221080384","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2019.05.011"},{"key":"bibr26-09636897221080384","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejheart.2007.07.008"},{"key":"bibr27-09636897221080384","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2009.130"},{"key":"bibr28-09636897221080384","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.644518"},{"key":"bibr29-09636897221080384","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2020.02.031"},{"key":"bibr30-09636897221080384","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2016.08.002"}],"container-title":["Cell Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09636897221080384","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/09636897221080384","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09636897221080384","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:39:05Z","timestamp":1777390745000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/09636897221080384"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":30,"alternative-id":["10.1177\/09636897221080384"],"URL":"https:\/\/doi.org\/10.1177\/09636897221080384","relation":{},"ISSN":["0963-6897","1555-3892"],"issn-type":[{"value":"0963-6897","type":"print"},{"value":"1555-3892","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1]]},"article-number":"09636897221080384"}}