{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T04:20:52Z","timestamp":1787631652921,"version":"build-2736575974"},"reference-count":28,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100010476","name":"Tata Memorial Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010476","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cell Transplant"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>\n                    Mucositis is nearly inevitable following high-dose chemotherapy. Several pro-inflammatory cytokines play a role in pathogenesis of mucositis. Curcumin inhibits inflammatory cytokines through inhibition of nuclear factor kappa-\u03b2. We studied the effects of curcumin on the acute toxicities and inflammatory cytokines following melphalan (200 mg\/m\n                    <jats:sup>2<\/jats:sup>\n                    ) for autologous hematopoietic stem cell transplantation (HSCT) for myeloma. The control group (first 10 enrolled patients who received standard supportive care) was compared with curcumin group (next 30 patients who received chewable curcumin lozenges, 4 g twice daily from 2 days before melphalan till day +28 along with standard supportive care). The toxicities were recorded as per World Health Organization (WHO) criteria and CTCAE v3.0 as applicable. Cytokine profiling was done in both groups at similar time points. In the curcumin group, there was significant decrease in grade 3\/4 vomiting (3% vs 40%,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.01) and total parenteral nutrition use (47% vs 90%,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.026). Grade 3\/4 mucositis (43% vs 60%) and diarrhea (33% vs 70%) were also less, but not statistically significant. This coincided with 3.2-fold lower area under the concentration time curve (AUC) of IL-8 from day \u20133 to day 14 in curcumin group compared with control group (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.039). We conclude that curcumin mitigates toxicities of high-dose melphalan, possibly through IL-8 modulation. Randomized studies are warranted to explore benefits of curcumin in HSCT.\n                  <\/jats:p>","DOI":"10.1177\/09636897221086969","type":"journal-article","created":{"date-parts":[[2022,4,18]],"date-time":"2022-04-18T06:15:49Z","timestamp":1650262549000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Role of Curcumin in Reducing Toxicities Associated With Mucosal Injury Following Melphalan-Based Conditioning in Autologous Transplant Setting"],"prefix":"10.1177","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7461-4772","authenticated-orcid":false,"given":"Sachin","family":"Punatar","sequence":"first","affiliation":[{"name":"Bone Marrow Transplantation Unit, Department of Medical Oncology, Advanced Centre for Treatment, Research &amp; Education in Cancer (ACTREC), Tata Memorial Centre, Navi Mumbai, India"},{"name":"Homi Bhabha National Institute, Mumbai, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kritika","family":"Katti","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Unit, Department of Medical Oncology, Advanced Centre for Treatment, Research &amp; Education in Cancer (ACTREC), Tata Memorial Centre, Navi Mumbai, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepan","family":"Rajamanickam","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Unit, Department of Medical Oncology, Advanced Centre for Treatment, Research &amp; Education in Cancer (ACTREC), Tata Memorial Centre, Navi Mumbai, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pravin","family":"Patil","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Unit, Department of Medical Oncology, Advanced Centre for Treatment, Research &amp; Education in Cancer (ACTREC), Tata Memorial Centre, Navi Mumbai, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chetan","family":"Dhakan","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology Laboratory, Advanced Centre for Treatment, Research &amp; Education in Cancer (ACTREC), Tata Memorial Centre, Navi Mumbai, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhausaheb","family":"Bagal","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Unit, Department of Medical Oncology, Advanced Centre for Treatment, Research &amp; Education in Cancer (ACTREC), Tata Memorial Centre, Navi Mumbai, India"},{"name":"Homi Bhabha National Institute, Mumbai, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anant","family":"Gokarn","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Unit, Department of Medical Oncology, Advanced Centre for Treatment, Research &amp; Education in Cancer (ACTREC), Tata Memorial Centre, Navi Mumbai, India"},{"name":"Homi Bhabha National Institute, Mumbai, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avinash","family":"Bonda","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Unit, Department of Medical Oncology, Advanced Centre for Treatment, Research &amp; Education in Cancer (ACTREC), Tata Memorial Centre, Navi Mumbai, India"},{"name":"Homi Bhabha National Institute, Mumbai, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingaraj","family":"Nayak","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Unit, Department of Medical Oncology, Advanced Centre for Treatment, Research &amp; Education in Cancer (ACTREC), Tata Memorial Centre, Navi Mumbai, India"},{"name":"Homi Bhabha National Institute, Mumbai, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murari","family":"Gurjar","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology Laboratory, Advanced Centre for Treatment, Research &amp; Education in Cancer (ACTREC), Tata Memorial Centre, Navi Mumbai, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadhana","family":"Kannan","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Advanced Centre for Treatment, Research &amp; Education in Cancer (ACTREC), Tata Memorial Centre, Navi Mumbai, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shubhada","family":"Chiplunkar","sequence":"additional","affiliation":[{"name":"Homi Bhabha National Institute, Mumbai, India"},{"name":"Department of Immunology, Advanced Centre for Treatment, Research &amp; Education in Cancer (ACTREC), Tata Memorial Centre, Navi Mumbai, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6348-6667","authenticated-orcid":false,"given":"Vikram","family":"Gota","sequence":"additional","affiliation":[{"name":"Homi Bhabha National Institute, Mumbai, India"},{"name":"Clinical Pharmacology Laboratory, Advanced Centre for Treatment, Research &amp; Education in Cancer (ACTREC), Tata Memorial Centre, Navi Mumbai, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Navin","family":"Khattry","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Unit, Department of Medical Oncology, Advanced Centre for Treatment, Research &amp; Education in Cancer (ACTREC), Tata Memorial Centre, Navi Mumbai, India"},{"name":"Homi Bhabha National Institute, Mumbai, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,4,18]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1702447"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/1078155215620920."},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1705384."},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdr391"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1996.14.4.1156"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.49.31092"},{"issue":"4","key":"e_1_3_3_8_2","article-title":"Regulation of tumor necrosis factor alpha transcription in macrophages: involvement of four kappa B-like motifs and of constitutive and inducible forms of NF-kappa B","volume":"10","author":"Collart MA","year":"1990","unstructured":"Collart MA, Baeuerle P, Vassalli P. Regulation of tumor necrosis factor alpha transcription in macrophages: involvement of four kappa B-like motifs and of constitutive and inducible forms of NF-kappa B. Mol Cell Biol. 1990;10(4):1498\u2013506.","journal-title":"Mol Cell Biol"},{"key":"e_1_3_3_9_2","unstructured":"Hofmeister CC Stiff PJ. Mucosal protection by cytokines. Curr Hematol Rep. 2005;4(6):466\u201353. https:\/\/pubmed.ncbi.nlm.nih.gov\/16232381\/."},{"issue":"2","key":"e_1_3_3_10_2","first-page":"9","article-title":"New strategies for management of oral mucositis in cancer patients","volume":"4","author":"Peterson DE","year":"2006","unstructured":"Peterson DE. New strategies for management of oral mucositis in cancer patients. J Support Oncol. 2006;4(2 Suppl 1):9\u201313.","journal-title":"J Support Oncol"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-006-0052-7"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0128763."},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/hon.2133."},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2004.09.003"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.42.24995"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/23.1.143"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1124\/mol.105.017400"},{"issue":"7","key":"e_1_3_3_18_2","article-title":"Pharmacodynamic and pharmacokinetic study of oral Curcuma extract in patients with colorectal cancer","volume":"7","author":"Sharma RA","year":"2001","unstructured":"Sharma RA, McLelland HR, Hill KA, Ireson CR, Euden SA, Manson MM, Pirmohamed M, Marnett LJ, Gescher AJ, Steward WP. Pharmacodynamic and pharmacokinetic study of oral Curcuma extract in patients with colorectal cancer. Clin Cancer Res. 2001;7(7):1894\u2013900.","journal-title":"Clin Cancer Res"},{"key":"e_1_3_3_19_2","article-title":"Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions","volume":"21","author":"Cheng AL","year":"2001","unstructured":"Cheng AL, Hsu CH, Lin JK, Hsu MM, Ho YF, Shen TS, Ko JY, Lin JT, Lin BR, Ming-Shiang W, Yu HS, et al. Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions. Anticancer Res. 2001;21(4B):2895\u2013900.","journal-title":"Anticancer Res"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1021\/jf9024807"},{"issue":"4","key":"e_1_3_3_21_2","article-title":"Protective effect of curcumin against irinotecan-induced intestinal mucosal injury via attenuation of NF-\u03baB activation, oxidative stress and endoplasmic reticulum stress","volume":"54","author":"Ouyang M","year":"2019","unstructured":"Ouyang M, Luo Z, Zhang W, Zhu D, Lu Y, Wu J, Yao X. Protective effect of curcumin against irinotecan-induced intestinal mucosal injury via attenuation of NF-\u03baB activation, oxidative stress and endoplasmic reticulum stress. Int J Oncol. 2019;54(4):1376\u201386.","journal-title":"Int J Oncol"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgm123"},{"issue":"8","key":"e_1_3_3_23_2","article-title":"Use of curcumin mouthrinse in radio-chemotherapy induced oral mucositis patients: a pilot study","volume":"9","author":"Patil K","year":"2015","unstructured":"Patil K, Guledgud MV, Kulkarni PK, Keshari D, Tayal S. Use of curcumin mouthrinse in radio-chemotherapy induced oral mucositis patients: a pilot study. J Clin Diagn Res. 2015;9(8):ZC59\u201362.","journal-title":"J Clin Diagn Res"},{"issue":"3","key":"e_1_3_3_24_2","first-page":"21","article-title":"Topical curcumin for the prevention of oral mucositis in pediatric patients: case series","volume":"19","author":"Elad S","year":"2013","unstructured":"Elad S, Meidan I, Sellam G, Simaan S, Zeevi I, Waldman E, Weintraub M, Revel-Vilk S. Topical curcumin for the prevention of oral mucositis in pediatric patients: case series. Altern Ther Health Med. 2013;19(3):21\u201324.","journal-title":"Altern Ther Health Med"},{"key":"e_1_3_3_25_2","unstructured":"Charantimath S. Use of curcumin in radiochemotherapy induced oral mucositis patients: a control trial study; 2016 Mar 1. https:\/\/zenodo.org\/record\/1124161#.X8nnWtgzY2w."},{"issue":"3","key":"e_1_3_3_26_2","article-title":"The effect of \u201cCurcuma Longa\u201d topical gel on radiation-induced oral mucositis in patients with head and neck cancer","volume":"13","author":"Mansourian A","year":"2015","unstructured":"Mansourian A, Amanlou M, Shirazian S, Moosavian Jahromi Z, Amirian A. The effect of \u201cCurcuma Longa\u201d topical gel on radiation-induced oral mucositis in patients with head and neck cancer. Int J Radiat Res. 2015;13(3):269\u201374.","journal-title":"Int J Radiat Res"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/scd.12358"},{"issue":"10","key":"e_1_3_3_28_2","doi-asserted-by":"crossref","DOI":"10.1002\/cncr.28592","article-title":"The Mucositis Guidelines Leadership Group of the Multinational Association of Supportive Care in Cancer and International Society of Oral Oncology (MASCC\/ISOO). MASCC\/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy","volume":"120","author":"Lalla RV","year":"2014","unstructured":"Lalla RV, Bowen J, Barasch A, Elting L, Epstein J, Keefe DM, McGuire DB, Migliorati C, Nicolatou-Galitis O, Peterson DE, Raber-Durlacher JE, et al. The Mucositis Guidelines Leadership Group of the Multinational Association of Supportive Care in Cancer and International Society of Oral Oncology (MASCC\/ISOO). MASCC\/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy. Cancer. 2014;120(10):1453\u201361.","journal-title":"Cancer"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2014.02.025"}],"container-title":["Cell Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09636897221086969","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/09636897221086969","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09636897221086969","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:39:08Z","timestamp":1777390748000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/09636897221086969"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":28,"alternative-id":["10.1177\/09636897221086969"],"URL":"https:\/\/doi.org\/10.1177\/09636897221086969","relation":{},"ISSN":["0963-6897","1555-3892"],"issn-type":[{"value":"0963-6897","type":"print"},{"value":"1555-3892","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1]]},"article-number":"09636897221086969"}}