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However, the optimal conditioning regimen needs to be explored. In the present study, 40 patients with T-LBL undergoing allo-HSCT were retrospectively analyzed, including 23\/40 (57.5%) with total body irradiation (TBI)\u2013based conditioning regimen and 17\/40 (42.5%) with busulfan (BU)-based regimen. TBI\u2013based regimen significantly increased the cumulative incidence (CI) of grade II to IV acute graft-versus-host disease (aGvHD) as compared with BU-based regimen (13.0% vs 0%, P = 0.000). The relapse risk was significantly lowered in TBI-based group with a 2-year CI of relapse (CIR) of 9.1% as compared with that of 49.6% in BU-based group ( P = 0.008). The 1-year and 2-year non-relapse mortalities (NRMs) for all patients were 5.0% and 10.3%, respectively. The 1-year and 2-year NRMs were 8.9% and 16.0% in TBI-based group, and 0.00% and 0.00% in BU-based group ( P = 0.140). The 2-year probabilities of overall survival (OS) and relapse-free survival (RFS) were 83.0% [95% confidence interval, 63.4%\u2013100%] and 74.0% (95% confidence interval, 54.4%\u201393.6%) in TBI-based group, which were higher than that of 35.0% (95% confidence interval, 0.0%\u201372.2%) and 50.0% (95% confidence interval, 24.5%\u201375.4%) in BU-based group, respectively ( P = 0.020 for OS and P = 0.081 for RFS). In multivariate analysis, TBI-based regimen significantly reduced the risk of relapse [subdistribution hazard ratio (SHR) = 0.030, 95% CI, 0.002\u20130.040, P = 0.000] and improved the OS [hazard ratio (HR) 0.121, 95% CI, 0.021\u20130.683, P = 0.017] as an independent prognostic factor. These results suggested that TBI-based regimen might be an optimal choice for adult patients with T-LBL undergoing allo-HSCT.<\/jats:p>","DOI":"10.1177\/09636897221108890","type":"journal-article","created":{"date-parts":[[2022,7,8]],"date-time":"2022-07-08T07:29:41Z","timestamp":1657265381000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Total Body Irradiation\u2013Based Conditioning Regimen Improved the Survival of Adult Patients With T-Cell Lymphoblastic Lymphoma After Allogeneic Peripheral Blood Stem Cell Transplantation"],"prefix":"10.1177","volume":"31","author":[{"given":"Jiahua","family":"Niu","sequence":"first","affiliation":[{"name":"Department of Hematology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China"},{"name":"Engineering Technology Research Center of Cell Therapy and Clinical Translation, Shanghai Science and Technology Committee, 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