{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T01:06:16Z","timestamp":1777511176942,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["No. 7222056"],"award-info":[{"award-number":["No. 7222056"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Capital\u2019s Funds for Health Improvement and Research","award":["No. 2022-1-2091"],"award-info":[{"award-number":["No. 2022-1-2091"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 82070154"],"award-info":[{"award-number":["No. 82070154"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cell Transplant"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:p>Allogeneic hematopoietic stem cell transplantation (HSCT) is an effective treatment for acute myeloid leukemia (AML). Pediatric patients with AML who relapse after HSCT have an extremely poor prognosis. We performed a retrospective study of pediatric patients diagnosed with AML from August 2015 to October 2019 who were treated with HSCT. Kaplan\u2013Meier analyses were used to evaluate overall survival (OS), event-free survival (EFS), and cumulative recurrence rate (CRR). Cox regression analysis was used to determine the association between the baseline characteristics and relapse. A total of 37 pediatric patients met the inclusion criteria. Twenty-eight (75.7%) patients survived, and 9 (24.3%) patients died. The OS rates of AML patients treated with HSCT were 89.2% \u00b1 5.1%, 75.7% \u00b1 7.1%, and 75.7% \u00b1 7.1% at 1, 3, and 5 years, respectively, and the CRRs were 11.4% \u00b1 5.4%, 24.7% \u00b1 7.7%, and 33.1% \u00b1 10.4% at 1, 3, and 5 years after HSCT, respectively; four of nine children who relapsed after transplantation died. Induction with etoposide rather than homoharringtonine and fungal infections could be high-risk factors for recurrence after transplantation. The association between homoharringtonine-based induction therapy and a low recurrence rate persisted after adjusting for age, sex, risk stratification, fusion genes, and fungal infections. This study clarifies the clinical features and poor prognosis of post-transplant relapse in pediatric AML and indicates the urgent need for effective therapy for patients who relapse after HSCT.<\/jats:p>","DOI":"10.1177\/09636897231183559","type":"journal-article","created":{"date-parts":[[2023,7,20]],"date-time":"2023-07-20T07:27:11Z","timestamp":1689838031000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Homoharringtonine-Based Induction Therapy Reduces the Recurrence Rate of Pediatric Acute Myeloid Leukemia After Allogeneic Hematopoietic Stem Cell Transplantation"],"prefix":"10.1177","volume":"32","author":[{"given":"Bin","family":"Wang","sequence":"first","affiliation":[{"name":"Transplantation Department, Hematology Center, Beijing Key Laboratory of Pediatric Hematology Oncology; National Key Clinical Discipline of Pediatric Hematology, National Key Discipline of Pediatrics (Capital Medical University); Key Laboratory of Major Diseases in Children, Ministry of Education; Beijing Children\u2019s Hospital, Capital Medical University, National Center for Children\u2019s Health, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaojia","family":"Wen","sequence":"additional","affiliation":[{"name":"Leukemia Department, Hematology Center, Beijing Key Laboratory of Pediatric Hematology Oncology; National Key Clinical Discipline of Pediatric Hematology, National Key Discipline of Pediatrics (Capital Medical University); Key Laboratory of Major Diseases in Children, Ministry of Education; Beijing Children\u2019s Hospital, Capital Medical University, National Center for Children\u2019s Health, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruidong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Leukemia Department, Hematology Center, Beijing Key Laboratory of Pediatric Hematology Oncology; National Key Clinical Discipline of Pediatric Hematology, National Key Discipline of Pediatrics (Capital Medical University); Key Laboratory of Major Diseases in Children, Ministry of Education; Beijing Children\u2019s Hospital, Capital Medical University, National Center for Children\u2019s Health, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guanghua","family":"Zhu","sequence":"additional","affiliation":[{"name":"Transplantation Department, Hematology Center, Beijing Key Laboratory of Pediatric Hematology Oncology; National Key Clinical Discipline of Pediatric Hematology, National Key Discipline of Pediatrics (Capital Medical University); Key Laboratory of Major Diseases in Children, Ministry of Education; Beijing Children\u2019s Hospital, Capital Medical University, National Center for Children\u2019s Health, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Wu","sequence":"additional","affiliation":[{"name":"Leukemia Department, Hematology Center, Beijing Key Laboratory of Pediatric Hematology Oncology; National Key Clinical Discipline of Pediatric Hematology, National Key Discipline of Pediatrics (Capital Medical University); Key Laboratory of Major Diseases in Children, Ministry of Education; Beijing Children\u2019s Hospital, Capital Medical University, National Center for Children\u2019s Health, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanyuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Leukemia Department, Hematology Center, Beijing Key Laboratory of Pediatric Hematology Oncology; National Key Clinical Discipline of Pediatric Hematology, National Key Discipline of Pediatrics (Capital Medical University); Key Laboratory of Major Diseases in Children, Ministry of Education; Beijing Children\u2019s Hospital, Capital Medical University, National Center for Children\u2019s Health, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Lin","sequence":"additional","affiliation":[{"name":"Leukemia Department, Hematology Center, Beijing Key Laboratory of Pediatric Hematology Oncology; National Key Clinical Discipline of Pediatric Hematology, National Key Discipline of Pediatrics (Capital Medical University); Key Laboratory of Major Diseases in Children, Ministry of Education; Beijing Children\u2019s Hospital, Capital Medical University, National Center for Children\u2019s Health, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaole","family":"Yu","sequence":"additional","affiliation":[{"name":"Leukemia Department, Hematology Center, Beijing Key Laboratory of Pediatric Hematology Oncology; National Key Clinical Discipline of Pediatric Hematology, National Key Discipline of Pediatrics (Capital Medical University); Key Laboratory of Major Diseases in Children, Ministry of Education; Beijing Children\u2019s Hospital, Capital Medical University, National Center for Children\u2019s Health, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia","family":"Fan","sequence":"additional","affiliation":[{"name":"Leukemia Department, Hematology Center, Beijing Key Laboratory of Pediatric Hematology Oncology; National Key Clinical Discipline of Pediatric Hematology, National Key Discipline of Pediatrics (Capital Medical University); Key Laboratory of Major Diseases in Children, Ministry of Education; Beijing Children\u2019s Hospital, Capital Medical University, National Center for Children\u2019s Health, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[{"name":"Leukemia Department, Hematology Center, Beijing Key Laboratory of Pediatric Hematology Oncology; National Key Clinical Discipline of Pediatric Hematology, National Key Discipline of Pediatrics (Capital Medical University); Key Laboratory of Major Diseases in Children, Ministry of Education; Beijing Children\u2019s Hospital, Capital Medical University, National Center for Children\u2019s Health, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Yang","sequence":"additional","affiliation":[{"name":"Transplantation Department, Hematology Center, Beijing Key Laboratory of Pediatric Hematology Oncology; National Key Clinical Discipline of Pediatric Hematology, National Key Discipline of Pediatrics (Capital Medical University); Key Laboratory of Major Diseases in Children, Ministry of Education; Beijing Children\u2019s Hospital, Capital Medical University, National Center for Children\u2019s Health, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maoquan","family":"Qin","sequence":"additional","affiliation":[{"name":"Transplantation Department, Hematology Center, Beijing Key Laboratory of Pediatric Hematology Oncology; National Key Clinical Discipline of Pediatric Hematology, National Key Discipline of Pediatrics (Capital Medical University); Key Laboratory of Major Diseases in Children, Ministry of Education; Beijing Children\u2019s Hospital, Capital Medical University, National Center for Children\u2019s Health, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1484-9131","authenticated-orcid":false,"given":"Huyong","family":"Zheng","sequence":"additional","affiliation":[{"name":"Leukemia Department, Hematology Center, Beijing Key Laboratory of Pediatric Hematology Oncology; National Key Clinical Discipline of Pediatric Hematology, National Key Discipline of Pediatrics (Capital Medical University); Key Laboratory of Major Diseases in Children, Ministry of Education; Beijing Children\u2019s Hospital, Capital Medical University, National Center for Children\u2019s Health, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,7,20]]},"reference":[{"key":"bibr1-09636897231183559","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)01541-0"},{"key":"bibr2-09636897231183559","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-018-0071-7"},{"key":"bibr3-09636897231183559","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(10)70090-5"},{"key":"bibr4-09636897231183559","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2014.00055"},{"key":"bibr5-09636897231183559","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.22612"},{"key":"bibr6-09636897231183559","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2014.10.006"},{"key":"bibr7-09636897231183559","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2012.06.014"},{"key":"bibr8-09636897231183559","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0000000000000572"},{"key":"bibr9-09636897231183559","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-01-261800"},{"issue":"2","key":"bibr10-09636897231183559","volume":"40","author":"Jia C","year":"2019","journal-title":"Journal of Capital Medical University"},{"key":"bibr11-09636897231183559","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-016-0319-5"},{"key":"bibr12-09636897231183559","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2015.234"},{"key":"bibr13-09636897231183559","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2017.02.012"},{"key":"bibr14-09636897231183559","volume":"375","author":"Newell LF","year":"2021","journal-title":"BMJ"},{"key":"bibr15-09636897231183559","volume":"12","author":"Blackmon A","year":"2022","journal-title":"Blood Lymphat Cancer"},{"key":"bibr16-09636897231183559","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(20)30060-7"},{"key":"bibr17-09636897231183559","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2021013972"},{"key":"bibr18-09636897231183559","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-022-03416-7"},{"key":"bibr19-09636897231183559","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(13)70152-9"},{"key":"bibr20-09636897231183559","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.15.6315"}],"container-title":["Cell Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09636897231183559","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/09636897231183559","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09636897231183559","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:39:37Z","timestamp":1777390777000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/09636897231183559"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":20,"alternative-id":["10.1177\/09636897231183559"],"URL":"https:\/\/doi.org\/10.1177\/09636897231183559","relation":{},"ISSN":["0963-6897","1555-3892"],"issn-type":[{"value":"0963-6897","type":"print"},{"value":"1555-3892","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1]]},"article-number":"09636897231183559"}}