{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T01:06:33Z","timestamp":1777511193059,"version":"3.51.4"},"reference-count":49,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cell Transplant"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:p>\n                    Stroke remains still the leading cause of long-term disability worldwide. Although interventions such as early reperfusion, intravenous thrombolysis, and endovascular revascularization have shown neurological benefit in stroke patients, there is still lack of effective treatment enabling regeneration of nervous tissue after cerebral ischemic episodes. Cell therapy is an evolving opportunity for stroke survivors with residual neurological deficits. The purpose of this study was to evaluate safety and potential efficacy of multiple administration of Hospital Exemption\u2014Advanced Therapy Medicinal Product (HE-ATMP) comprising 3 \u00d7 10\n                    <jats:sup>7<\/jats:sup>\n                    Wharton\u2019s jelly mesenchymal stem cells (WJMSCs). A study group was composed of six patients\u2014three women and three men. The patients were qualified to the treatment with diagnosis of chronic stroke (2\u201324 months after cerebral ischemic episode), during 2 years. All the patients undergone repeated rounds of HE-ATMP administration to the CSF (cerebrospinal fluid) via lumbar puncture. The control group consisted of six patients (two women and four men) who experienced stroke, treated at the same time (follow-up period: 24 months) using standard treatment methods, without endovascular treatment. To evaluate the results of the therapy, we used both impairment scales [National Institutes of Health Stroke Score (NIHSS)] and functional outcomes scales [Modified Rankin Scale (MRS) and Barthel Index (BI)]. In four patients, who received at least three repeated rounds of HE-ATMP, we reported neurological improvement and reduction of functional neurodeficiency. The biggest improvement concerned the reduction of speech disorders in two cases; significant improvement in the field of motor skills in three patients and reduction of apraxia and improvement of logical communication skills in two patients were also reported. All the patients became more independent. Significant improvement of the neurological condition using the same scales was registered only in two patients from the control group. We did not report any adverse events in the treated group during follow-up. At 1-year follow-up, we demonstrate safety and beneficial effect of WJMSC transplantation including neurological improvement and reduction of functional neurodeficiency. We are aware that the samples size of this study is relatively small. The treatment regimen needs to be further tested in larger group of patients.\n                  <\/jats:p>","DOI":"10.1177\/09636897231195145","type":"journal-article","created":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T02:41:55Z","timestamp":1693363315000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Comparative Analysis of the Results of Stroke Treatment With Multiple Administrations of Wharton\u2019s Jelly Mesenchymal Stem Cells\u2013Derived HE-ATMP and Standard Conservative Treatment: Case Series Study"],"prefix":"10.1177","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8565-1384","authenticated-orcid":false,"given":"Olga","family":"Milczarek","sequence":"first","affiliation":[{"name":"Department of Children\u2019s Neurosurgery, Institute of Pediatrics, Faculty of Medicine, Jagiellonian University Medical College, Cracow, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jakub","family":"Swad\u017aba","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Andrzej Frycz\u2013Modrzewski Cracow University, Cracow, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1900-3503","authenticated-orcid":false,"given":"Patrycja","family":"Swad\u017aba","sequence":"additional","affiliation":[{"name":"RegenMed Limited Liability Company, Cracow, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Starowicz-Filip","sequence":"additional","affiliation":[{"name":"Department of Psychology, Faculty of Medicine, Jagiellonian University Medical College, Cracow, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger M.","family":"Krzy\u017cewski","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and Neurotraumatology, Faculty of Medicine, Jagiellonian University Medical College, Cracow, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stanis\u0142aw","family":"Kwiatkowski","sequence":"additional","affiliation":[{"name":"Department of Children\u2019s Neurosurgery, Institute of Pediatrics, Faculty of Medicine, Jagiellonian University Medical College, Cracow, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcin","family":"Majka","sequence":"additional","affiliation":[{"name":"Department of Transplantation, Faculty of Medicine, Jagiellonian University Medical College, Cracow, 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