{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T01:06:54Z","timestamp":1777511214137,"version":"3.51.4"},"reference-count":41,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100020084","name":"Guangzhou Municipal Science and Technology Bureau","doi-asserted-by":"publisher","award":["202201010936"],"award-info":[{"award-number":["202201010936"]}],"id":[{"id":"10.13039\/501100020084","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010256","name":"Guangzhou Municipal Science and Technology Project","doi-asserted-by":"publisher","award":["201803010012"],"award-info":[{"award-number":["201803010012"]}],"id":[{"id":"10.13039\/501100010256","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cell Transplant"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:p>\n                    Mesenchymal stem cells (MSCs) have become a promising therapeutic method. More safety data are needed to support clinical studies in more diseases. The aim of this study was to investigate the short- and long-term safety of human bone marrow\u2013derived MSCs (hBMMSCs) in mice. In the present study, we injected control (saline infusion only), low (1.0 \u00d7 10\n                    <jats:sup>6<\/jats:sup>\n                    \/kg), medium (1.0 \u00d7 10\n                    <jats:sup>7<\/jats:sup>\n                    \/kg), and high (1.0 \u00d7 10\n                    <jats:sup>8<\/jats:sup>\n                    \/kg) concentrations of hBMMSCs into BALB\/c mice. The safety of the treatment was evaluated by observing changes in the general condition, hematology, biochemical indices, pathology of vital organs, lymphocyte subsets, and immune factor levels on days 14 and 150. In the short-term toxicity test, no significant abnormalities were observed in the hematological and biochemical parameters between the groups injected with hBMMSCs, and no significant damage was observed in the major organs, such as the liver and lung. In addition, no significant differences were observed in the toxicity-related parameters among the groups in the long-term toxicity test. Our study also demonstrates that mice infused with different doses of hBMMSCs do not show abnormal immune responses in either short-term or long-term experiments. We confirmed that hBMMSCs are safe through a 150-day study, demonstrating that this is a safe and promising therapy and offering preliminary safety evidence to promote future clinical applications of hBMMSCs in different diseases.\n                  <\/jats:p>","DOI":"10.1177\/09636897231213271","type":"journal-article","created":{"date-parts":[[2023,12,7]],"date-time":"2023-12-07T03:56:49Z","timestamp":1701921409000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Preclinical Short-term and Long-term Safety of Human Bone Marrow Mesenchymal Stem Cells"],"prefix":"10.1177","volume":"32","author":[{"given":"Ziyang","family":"Liang","sequence":"first","affiliation":[{"name":"Department of Hematology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China"},{"name":"Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoyang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hematology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China"},{"name":"Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GuangTing","family":"Gan","sequence":"additional","affiliation":[{"name":"Department of Hematology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China"},{"name":"Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China"},{"name":"Department of Oncology, Guizhou Provincial People\u2019s Hospital, Guiyang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duolan","family":"Naren","sequence":"additional","affiliation":[{"name":"Department of Hematology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China"},{"name":"Department of Hematology, Guangdong Provincial Hospital of Traditional Chinese Medicine, The Second Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Hematology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China"},{"name":"Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongyun","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Hematology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China"},{"name":"Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiani","family":"Mo","sequence":"additional","affiliation":[{"name":"Department of Hematology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China"},{"name":"Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shengqin","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Hematology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China"},{"name":"Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danian","family":"Nie","sequence":"additional","affiliation":[{"name":"Department of Hematology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China"},{"name":"Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4636-928X","authenticated-orcid":false,"given":"Liping","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Hematology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China"},{"name":"Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,12,7]]},"reference":[{"key":"bibr1-09636897231213271","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-018-0023-5"},{"key":"bibr2-09636897231213271","doi-asserted-by":"publisher","DOI":"10.1002\/stem.3016"},{"key":"bibr3-09636897231213271","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2018.05.004"},{"key":"bibr4-09636897231213271","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0175449"},{"key":"bibr5-09636897231213271","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kel158"},{"key":"bibr6-09636897231213271","doi-asserted-by":"publisher","DOI":"10.1186\/s41232-017-0045-6"},{"key":"bibr7-09636897231213271","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4614-5711-4_22"},{"key":"bibr8-09636897231213271","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2021.09.006"},{"key":"bibr9-09636897231213271","volume":"16","author":"Friedenstein 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