{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T17:34:17Z","timestamp":1787765657033,"version":"build-2784847793"},"reference-count":23,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Department of Ji\u2019nan Science & Technology Bureau","award":["2022TSGC2001"],"award-info":[{"award-number":["2022TSGC2001"]}]},{"name":"Department of Industry and Information Technology of Shandong Province","award":["202020100416"],"award-info":[{"award-number":["202020100416"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cell Transplant"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>Lead acetate can cause testicular damage in males. In this study, we assessed the repairing effects of human umbilical cord mesenchymal stem cells (MSCs) on testicular injury caused by lead acetate in mice. MSCs were injected into mice with testicular injury by intraperitoneal injection, and the organ coefficient of reproductive organs, sperm motility, hormone level and antioxidant index of mice were tested. Compared with the normal group, the coefficient of reproductive organs and sperm motility were reduced in the model group, and histopathology showed obvious testicular injury, proving successful modeling. Compared with the model group, the reproductive organ coefficient and sperm motility were improved in the experimental group, and histopathology showed that the testicular injury could be significantly improved. Sex hormone secretion tends to be normal, and the antioxidant index increased. Sequencing results showed that there were 485 upregulated genes and 172 downregulated genes between the model group and the control group, and 210 upregulated genes and 482 downregulated genes between the experimental group and the model group. Differentially expressed genes are mainly concentrated in AMP-activated protein kinase (AMPK) signaling pathway, apoptosis signaling pathway, and arginine biosynthesis signaling pathway. Overall, MSCs can significantly improve the degree of damages to mice testis caused by lead acetate and have a certain repairing effect.<\/jats:p>","DOI":"10.1177\/09636897231219395","type":"journal-article","created":{"date-parts":[[2024,1,4]],"date-time":"2024-01-04T02:13:10Z","timestamp":1704334390000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Repairing Effect of Mesenchymal Stem Cells on Lead Acetate-Induced Testicular Injury in Mice"],"prefix":"10.1177","volume":"33","author":[{"given":"Shasha","family":"Zhao","sequence":"first","affiliation":[{"name":"Jinan Perfect Biological Technology Co. Ltd., Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaozhi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, The First Affiliated Hospital of Shandong First Medical University, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The First Hospital Affiliated with Shandong First Medical University, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Dai","sequence":"additional","affiliation":[{"name":"Jinan Perfect Biological Technology Co. Ltd., Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Xu","sequence":"additional","affiliation":[{"name":"Jinan Perfect Biological Technology Co. 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