{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T23:31:40Z","timestamp":1793316700048,"version":"4.5.0"},"reference-count":40,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970158"],"award-info":[{"award-number":["81970158"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070179"],"award-info":[{"award-number":["82070179"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82130003"],"award-info":[{"award-number":["82130003"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cell Transplant"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>KMT2A rearrangement ( KMT2A-r) in patients with acute myeloid leukemia (AML) is associated with poor outcomes; the prognostic factors after allogeneic hematopoietic stem cell transplantation (allo-HSCT) remain unclear. We investigated 364 adults with AML who underwent allo-HSCT between April 2016 and May 2022, and 45 had KMT2A-r among them. Propensity score analysis with 1:1 matching and the nearest neighbor matching method identified 42 patients in KMT2A-r and non\u2013 KMT2A-r cohorts, respectively. The 2-year overall survival (OS), relapse-free survival (RFS), cumulative incidence of relapse (CIR), and non-relapsed mortality rates of patients with KMT2A-r ( n = 45) were 59.1%, 49.6%, 41.5%, and 8.9%, respectively. Using propensity score matching, the 2-year OS rate of patients with KMT2A-r ( n = 42) was lower than that of those without KMT2A-r ( n = 42; 56.1% vs 88.1%, P = 0.003). Among patients with KMT2A-r ( n = 45), the prognostic advantage was exhibited from transplantation in first complete remission (CR1) and measurable residual disease (MRD) negative, which was reflected in OS, RFS, and CIR ( P &lt; 0.001, P &lt; 0.001, and P = 0.002, respectively). Furthermore, patients with AF6 had poorer outcomes than those with AF9, ELL, and other KMT2A-r subtypes ( P = 0.032, P = 0.001, and P = 0.001 for OS, RFS, and CIR, respectively). However, no differences were found in the OS, RFS, and CIR between patients with KMT2A-r with and without mutations (all P &gt; 0.05). Univariate and multivariate analyses revealed that achieving CR1 MRD negative before HSCT was a protective factor for OS [hazard ratio (HR) = 0.242, P = 0.007], RFS (HR = 0.350, P = 0.036), and CIR (HR = 0.271, P = 0.021), while AF6 was a risk factor for RFS (HR = 2.985, P = 0.028) and CIR (HR = 4.675, P = 0.004). The prognosis of patients with KMT2A-r AML was poor, particularly those harboring AF6-related translocation; however, it is not associated with the presence of mutations. These patients can benefit from achieving CR1 MRD negative before HSCT.<\/jats:p>","DOI":"10.1177\/09636897231225821","type":"journal-article","created":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T07:20:38Z","timestamp":1706167238000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Outcomes of Allogeneic Hematopoietic Stem Cell Transplantation in Adult Patients With Acute Myeloid Leukemia Harboring\n                    <i>KMT2A<\/i>\n                    Rearrangement and Its Prognostic Factors"],"prefix":"10.1177","volume":"33","author":[{"given":"Bingqian","family":"Jiang","sequence":"first","affiliation":[{"name":"Bone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People\u2019s Republic of China"},{"name":"Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou, People\u2019s Republic of China"},{"name":"Institute of Hematology, Zhejiang University, Hangzhou, People\u2019s Republic of China"},{"name":"Zhejiang Province Engineering Laboratory for Stem Cell and Immunity Therapy, Hangzhou, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanmin","family":"Zhao","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People\u2019s Republic of China"},{"name":"Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou, People\u2019s Republic of China"},{"name":"Institute of Hematology, Zhejiang University, Hangzhou, People\u2019s Republic of China"},{"name":"Zhejiang Province Engineering Laboratory for Stem Cell and Immunity Therapy, Hangzhou, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Luo","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People\u2019s Republic of China"},{"name":"Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou, People\u2019s Republic of China"},{"name":"Institute of Hematology, Zhejiang University, Hangzhou, People\u2019s Republic of China"},{"name":"Zhejiang Province Engineering Laboratory for Stem Cell and Immunity Therapy, Hangzhou, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Yu","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People\u2019s Republic of China"},{"name":"Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou, People\u2019s Republic of China"},{"name":"Institute of Hematology, Zhejiang University, Hangzhou, People\u2019s Republic of China"},{"name":"Zhejiang Province Engineering Laboratory for Stem Cell and Immunity Therapy, Hangzhou, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Hematology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou Key Laboratory of Hematology, Wenzhou, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baodong","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Hematology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huarui","family":"Fu","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People\u2019s Republic of 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People\u2019s Republic of China"},{"name":"Institute of Hematology, Zhejiang University, Hangzhou, People\u2019s Republic of China"},{"name":"Zhejiang Province Engineering Laboratory for Stem Cell and Immunity Therapy, Hangzhou, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiyan","family":"Zheng","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People\u2019s Republic of China"},{"name":"Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou, People\u2019s Republic of China"},{"name":"Institute of Hematology, Zhejiang University, Hangzhou, People\u2019s Republic of China"},{"name":"Zhejiang Province Engineering Laboratory for Stem Cell and Immunity Therapy, Hangzhou, People\u2019s Republic of 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People\u2019s Republic of China"},{"name":"Institute of Hematology, Zhejiang University, Hangzhou, People\u2019s Republic of China"},{"name":"Zhejiang Province Engineering Laboratory for Stem Cell and Immunity Therapy, Hangzhou, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhao","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People\u2019s Republic of China"},{"name":"Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou, People\u2019s Republic of China"},{"name":"Institute of Hematology, Zhejiang University, Hangzhou, People\u2019s Republic of China"},{"name":"Zhejiang Province Engineering Laboratory for Stem Cell and Immunity Therapy, Hangzhou, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoqing","family":"Wei","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People\u2019s Republic of China"},{"name":"Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou, People\u2019s Republic of China"},{"name":"Institute of Hematology, Zhejiang University, Hangzhou, People\u2019s Republic of China"},{"name":"Zhejiang Province Engineering Laboratory for Stem Cell and Immunity Therapy, Hangzhou, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Cai","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People\u2019s Republic of China"},{"name":"Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou, 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