{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T23:05:54Z","timestamp":1788390354170,"version":"build-2803163510"},"reference-count":40,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Tata Memorial Centre - Intramural Annual Scientific Funding","award":["4598-C"],"award-info":[{"award-number":["4598-C"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cell Transplant"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>Acute graft versus host disease (aGvHD) is the major contributor of nonrelapse mortality in alloHSCT. It is associated with an inflammatory immune response manifesting as cytokine storm with ensuing damage to target organs such as liver, gut, and skin. Prevention of aGvHD while retaining the beneficial graft versus leukemia (GvL) effect remains a major challenge. Withania somnifera extract (WSE) is known for its anti-inflammatory, immune-modulatory, and anticancer properties, which are appealing in the context of aGvHD. Herein, we demonstrated that prophylactic and therapeutic use of WSE in experimental model of alloHSCT mitigates aGvHD-associated morbidity and mortality. In the prophylaxis study, a dose of 75 mg\/kg of WSE offered greatest protection against death due to aGvHD (hazard ratio [HR] = 0.15 [0.03-0.68], P \u2264 .01), whereas 250 mg\/kg was most effective for the treatment of aGvHD (HR = 0.16 [0.05-0.5], P \u2264 .01). WSE treatment protected liver, gut, and skin from damage by inhibiting cytokine storm and lymphocytic infiltration to aGvHD target organs. In addition, WSE did not compromise the GvL effect, as alloHSCT with or without WSE did not allow the leukemic A20 cells to grow. In fact, WSE showed marginal antileukemic effect in vivo. WSE is currently under clinical investigation for the prevention and treatment of aGvHD.<\/jats:p>","DOI":"10.1177\/09636897241226573","type":"journal-article","created":{"date-parts":[[2024,1,23]],"date-time":"2024-01-23T07:49:11Z","timestamp":1705996151000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["<i>Withania Somnifera<\/i>\n                    Extract Mitigates Experimental Acute Graft versus Host Disease Without Abrogating Graft Versus Leukemia Effect"],"prefix":"10.1177","volume":"33","author":[{"given":"Saurabh Kumar","family":"Gupta","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacology, Advanced Centre for Treatment, Research and Education in Cancer, Tata Memorial Centre, Navi Mumbai, India"},{"name":"Homi Bhabha National Institute, Mumbai, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dievya","family":"Gohil","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, Advanced Centre for Treatment, Research and Education in Cancer, Tata Memorial Centre, Navi Mumbai, India"},{"name":"Homi Bhabha National Institute, Mumbai, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohd Bashar","family":"Momin","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, Advanced Centre for Treatment, Research and Education in Cancer, Tata Memorial Centre, Navi Mumbai, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subhash","family":"Yadav","sequence":"additional","affiliation":[{"name":"Homi Bhabha National Institute, Mumbai, India"},{"name":"Department of Pathology, Tata Memorial Hospital, Mumbai, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akanksha","family":"Chichra","sequence":"additional","affiliation":[{"name":"Homi Bhabha National Institute, Mumbai, India"},{"name":"Department of Medical Oncology, Advanced Centre for Treatment, Research and Education in Cancer, Tata Memorial Centre, Navi Mumbai, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachin","family":"Punatar","sequence":"additional","affiliation":[{"name":"Homi Bhabha National Institute, Mumbai, India"},{"name":"Department of Medical Oncology, Advanced Centre for Treatment, Research and Education in Cancer, Tata Memorial Centre, Navi Mumbai, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anant","family":"Gokarn","sequence":"additional","affiliation":[{"name":"Homi Bhabha National Institute, Mumbai, India"},{"name":"Department of Medical Oncology, Advanced Centre for Treatment, Research and Education in Cancer, Tata Memorial Centre, Navi Mumbai, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumeet","family":"Mirgh","sequence":"additional","affiliation":[{"name":"Homi Bhabha National Institute, Mumbai, India"},{"name":"Department of Medical Oncology, Advanced Centre for Treatment, Research and Education in Cancer, Tata Memorial Centre, Navi Mumbai, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nishant","family":"Jindal","sequence":"additional","affiliation":[{"name":"Homi Bhabha National Institute, Mumbai, India"},{"name":"Department of Medical Oncology, Advanced Centre for Treatment, Research and Education in Cancer, Tata Memorial Centre, Navi Mumbai, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingaraj","family":"Nayak","sequence":"additional","affiliation":[{"name":"Homi Bhabha National Institute, Mumbai, India"},{"name":"Department of Medical Oncology, Advanced Centre for Treatment, Research and Education in Cancer, Tata Memorial Centre, Navi Mumbai, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lal","family":"Hingorani","sequence":"additional","affiliation":[{"name":"Pharmanza Herbal Pvt. Ltd., Anand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Navin","family":"Khattry","sequence":"additional","affiliation":[{"name":"Homi Bhabha National Institute, Mumbai, India"},{"name":"Department of Medical Oncology, Advanced Centre for Treatment, Research and Education in Cancer, Tata Memorial Centre, Navi Mumbai, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6348-6667","authenticated-orcid":false,"given":"Vikram","family":"Gota","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, Advanced Centre for Treatment, Research and Education in Cancer, Tata Memorial Centre, Navi Mumbai, India"},{"name":"Homi Bhabha National Institute, Mumbai, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,1,23]]},"reference":[{"key":"bibr1-09636897241226573","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-102119-073227"},{"key":"bibr2-09636897241226573","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1609337"},{"key":"bibr3-09636897241226573","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2021.102286"},{"key":"bibr4-09636897241226573","doi-asserted-by":"publisher","DOI":"10.15171\/bi.2014.001"},{"key":"bibr5-09636897241226573","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjp.2014.03.006"},{"issue":"2","key":"bibr6-09636897241226573","first-page":"1","volume":"1","author":"Mohamed I","year":"2012","journal-title":"Int J Herb Plant Med"},{"key":"bibr7-09636897241226573","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0067171"},{"key":"bibr8-09636897241226573","doi-asserted-by":"publisher","DOI":"10.1179\/1607845413Y.0000000076"},{"key":"bibr9-09636897241226573","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0169630"},{"key":"bibr10-09636897241226573","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2019.11.019"},{"key":"bibr11-09636897241226573","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-015-2012-1"},{"issue":"12","key":"bibr12-09636897241226573","volume":"23","author":"Saleem S","year":"2020","journal-title":"Iran J Basic Med Sci"},{"key":"bibr13-09636897241226573","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2023.110437"},{"key":"bibr14-09636897241226573","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00079"},{"key":"bibr15-09636897241226573","doi-asserted-by":"publisher","DOI":"10.3727\/096368912X653110"},{"key":"bibr16-09636897241226573","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-019-0394-z"},{"key":"bibr17-09636897241226573","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.760789"},{"key":"bibr18-09636897241226573","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2015.05.011"},{"issue":"1","key":"bibr19-09636897241226573","first-page":"90","volume":"2","author":"Kumar S","year":"2017","journal-title":"J Immunol Res Ther"},{"key":"bibr20-09636897241226573","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.03041"},{"key":"bibr21-09636897241226573","doi-asserted-by":"publisher","DOI":"10.1007\/s40261-021-01087-6"},{"key":"bibr22-09636897241226573","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2015.09.014"},{"key":"bibr23-09636897241226573","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.106575"},{"key":"bibr24-09636897241226573","volume":"9","author":"Gupta SK","year":"2022","journal-title":"Toxicol Rep"},{"key":"bibr25-09636897241226573","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaim.2018.12.008"},{"key":"bibr26-09636897241226573","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.112175"},{"key":"bibr27-09636897241226573","doi-asserted-by":"publisher","DOI":"10.3109\/13880209.2015.1027778"},{"key":"bibr28-09636897241226573","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0075069"},{"key":"bibr29-09636897241226573","doi-asserted-by":"publisher","DOI":"10.4314\/ajtcam.v8i5S.9"},{"key":"bibr30-09636897241226573","doi-asserted-by":"publisher","DOI":"10.3390\/toxins8050147"},{"key":"bibr31-09636897241226573","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.2180"},{"key":"bibr32-09636897241226573","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-018-2192-y"},{"key":"bibr33-09636897241226573","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-017-0975-6"},{"key":"bibr34-09636897241226573","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6882-11-34"},{"key":"bibr35-09636897241226573","volume":"1","author":"Vedi M","year":"2014","journal-title":"Toxicol Rep"},{"key":"bibr36-09636897241226573","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-12-041889"},{"key":"bibr37-09636897241226573","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2019.10.028"},{"key":"bibr38-09636897241226573","first-page":"52","volume":"131","author":"Smith T","year":"2021","journal-title":"HerbalGram"},{"key":"bibr39-09636897241226573","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaim.2015.08.001"},{"key":"bibr40-09636897241226573","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27051476"}],"container-title":["Cell Transplantation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09636897241226573","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/09636897241226573","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09636897241226573","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:39:54Z","timestamp":1777390794000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.sagepub.com\/doi\/10.1177\/09636897241226573"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":40,"alternative-id":["10.1177\/09636897241226573"],"URL":"https:\/\/doi.org\/10.1177\/09636897241226573","relation":{},"ISSN":["0963-6897","1555-3892"],"issn-type":[{"value":"0963-6897","type":"print"},{"value":"1555-3892","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1]]},"article-number":"09636897241226573"}}