{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T02:34:08Z","timestamp":1792809248476,"version":"4.5.0"},"reference-count":171,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,3,16]],"date-time":"2024-03-16T00:00:00Z","timestamp":1710547200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2024,3,16]],"date-time":"2024-03-16T00:00:00Z","timestamp":1710547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cell Transplant"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:p>\n                    The scale of the cosmetic market is increasing every day. There are many safety risks to cosmetics, but they benefit people at the same time. The skin can become red, swollen, itchy, chronically toxic, and senescent due to the misuse of cosmetics, triggering skin injuries, with contact dermatitis being the most common. Therefore, there is an urgent need for a system that can scientifically and rationally detect the composition and perform a toxicological assessment of cosmetic products. Traditional detection methods rely on instrumentation and method selection, which are less sensitive and more complex to perform. Engineered skin tissue has emerged with the advent of tissue engineering technology as an emerging bioengineering technology. The ideal engineered skin tissue is the basis for building good\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    structures and physiological functions in this field. This review introduces the existing cosmetic testing and toxicological evaluation methods, the current development status, and the types and characteristics of engineered skin tissue. The application of engineered skin tissue in the field of cosmetic composition detection and toxicological evaluation, as well as the different types of tissue engineering scaffold materials and three-dimensional (3D) organoid preparation approaches, is highlighted in this review to provide methods and ideas for constructing the next engineered skin tissue for cosmetic raw material component analysis and toxicological evaluation.\n                  <\/jats:p>","DOI":"10.1177\/09636897241235464","type":"journal-article","created":{"date-parts":[[2024,3,16]],"date-time":"2024-03-16T08:21:00Z","timestamp":1710577260000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":23,"title":["Applications of Engineered Skin Tissue for Cosmetic Component and Toxicology Detection"],"prefix":"10.1177","volume":"33","author":[{"given":"Min","family":"Wang","sequence":"first","affiliation":[{"name":"College of Chemistry and Materials Engineering, Beijing Technology and Business University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7814-8964","authenticated-orcid":false,"given":"Linfeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Chemistry and Materials Engineering, Beijing Technology and Business University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haojie","family":"Hao","sequence":"additional","affiliation":[{"name":"The First Medical Center, Chinese People\u2019s Liberation Army General Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muyang","family":"Yan","sequence":"additional","affiliation":[{"name":"The First Medical Center, Chinese People\u2019s Liberation Army General Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziying","family":"Zhu","sequence":"additional","affiliation":[{"name":"The First Medical Center, Chinese People\u2019s Liberation Army General Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,3,16]]},"reference":[{"key":"e_1_3_3_2_2","unstructured":"China SCOTPSRO. Cosmetics supervision and management regulations; 2021. https:\/\/www.gov.cn\/zhengce\/content\/2020-06\/29\/content_5522593.htm"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0243591"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.2174\/1386207323666200630113850"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.202101007"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.7150\/thno.47413"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27165090"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2021.113993"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2021.462664"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26164900"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-023-03550-z"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2022.113429"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222212200"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2020.00033"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232314582"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1177\/09636897231210750"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1177\/09636897231218408"},{"key":"e_1_3_3_18_2","first-page":"14","article-title":"Efficacy and toxicity of anise oil as a potential topical wound healer: a cell culture study","volume":"27","author":"Sungur I","year":"2023","unstructured":"Sungur I, Bayar Muluk N, Vejselova Sezer C, Kutlu HM, Cingi C. Efficacy and toxicity of anise oil as a potential topical wound healer: a cell culture study. Eur Rev Med Pharmacol Sci. 2023;27(Suppl 2):14\u201320.","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.36319"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24032717"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/ics.12803"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2021.105133"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2021.153000"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1039\/D1NR01314A"},{"issue":"40","key":"e_1_3_3_25_2","article-title":"Adipose mesenchymal stem cell derived exosomes promote keratinocytes and fibroblasts embedded in collagen\/platelet-rich plasma scaffold and accelerate wound healing","volume":"35","author":"Wang Y","year":"2023","unstructured":"Wang Y, Zhang Y, Li T, Shen K, Wang KJ, Tian C, Hu D. Adipose mesenchymal stem cell derived exosomes promote keratinocytes and fibroblasts embedded in collagen\/platelet-rich plasma scaffold and accelerate wound healing. Adv Mater. 2023;35(40):e2303642.","journal-title":"Adv Mater"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2023.04.034"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells10071834"},{"key":"e_1_3_3_28_2","article-title":"Reciprocal interaction between vascular niche and sweat gland promotes sweat gland regeneration","volume":"21","author":"Yuan X","year":"2023","unstructured":"Yuan X, Duan X, Li Z, Yao B, Song W, Wang Y, Kong Y, Zhu S, Zhang F, Liang L, Zhang M, et al. Reciprocal interaction between vascular niche and sweat gland promotes sweat gland regeneration. Bioact Mater. 2023;21:340\u201357.","journal-title":"Bioact Mater"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-022-07549-0"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1093\/mutage\/geaa009"},{"issue":"1","key":"e_1_3_3_31_2","first-page":"40","article-title":"Bioengineered skin organoids: from development to applications","volume":"10","author":"Hong Z-X","year":"2023","unstructured":"Hong Z-X, Zhu S-T, Li H, Luo JZ, Yang Y, An Y, Wang X, Wang K. Bioengineered skin organoids: from development to applications. Mil Med Res. 2023;10(1):40.","journal-title":"Mil Med Res"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2022.114574"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28062874"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2020.121710"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1039\/C9AN02145K"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1177\/02611929231184635"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2023.463855"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2020.119127"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.saa.2022.121577"},{"issue":"5","key":"e_1_3_3_40_2","article-title":"Fluorescent probe based on \u03b2-CD@AuNPs for detection of sex hormones in cosmetics","volume":"40","author":"Meng-Meng D","year":"2023","unstructured":"Meng-Meng D, Chan W, Guo-Xia RAN, et al. Fluorescent probe based on \u03b2-CD@AuNPs for detection of sex hormones in cosmetics. Fine Chem. 2023;40(5):1029\u201334.","journal-title":"Fine Chem"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1002\/elps.202100236"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2023.115848"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.2174\/0929867324666171005103712"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioelechem.2022.108139"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2021.130472"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1467-2494.2001.00098.x"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.03.051"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2004.01.026"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1002\/jat.3129"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2016.09.041"},{"issue":"12","key":"e_1_3_3_51_2","article-title":"Rapid determination of chloramphenicol in cosmetics using direct real\u2014time analysis\u2014high resolution mass spectrometry","volume":"38","author":"Lan M","year":"2019","unstructured":"Lan M, Shao L, Chen S. Rapid determination of chloramphenicol in cosmetics using direct real\u2014time analysis\u2014high resolution mass spectrometry. J Instr Anal. 2019;38(12):1503\u2013506.","journal-title":"J Instr Anal"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.5740\/jaoacint.13-314"},{"issue":"6","key":"e_1_3_3_53_2","article-title":"Determination of hydroquinone and phenol in whitening cosmetics by column switching two-dimensional HPLC","volume":"42","author":"Wang T","year":"2022","unstructured":"Wang T, Wang J, Zhang L. Determination of hydroquinone and phenol in whitening cosmetics by column switching two-dimensional HPLC. Chin J Pharm Anal. 2022;42(6):1065\u201371.","journal-title":"Chin J Pharm Anal"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(02)01411-5"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2006.07.068"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2020.110488"},{"issue":"5","key":"e_1_3_3_57_2","article-title":"Ordered mesoporous silicon doped with HPMo-SiO2 solid phase extraction of trace Pb prior to flame atomic absorption spectrometry determination","volume":"13","author":"Liu J","year":"2018","unstructured":"Liu J, Sun H, Zheng Y, Wang Q, Guo J, Wu Y. Ordered mesoporous silicon doped with HPMo-SiO2 solid phase extraction of trace Pb prior to flame atomic absorption spectrometry determination. Inst Eng Technol. 2018;13(5):606\u201310.","journal-title":"Inst Eng Technol"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2015.01.011"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsps.2011.05.002"},{"issue":"3","key":"e_1_3_3_60_2","first-page":"82","article-title":"Graphite furnace atomic absorption spectrometry (GFAAS) methodology for trace element determination in eye shadow and lipstick","volume":"30","author":"Atz V","year":"2009","unstructured":"Atz V, Pozebon D, Spectroscopy A. Graphite furnace atomic absorption spectrometry (GFAAS) methodology for trace element determination in eye shadow and lipstick. At Spectrosc. 2009;30(3):82\u201391.","journal-title":"At Spectrosc"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2494.2009.00517_5.x"},{"key":"e_1_3_3_62_2","first-page":"1","article-title":"Human exposure to heavy metal from cosmetics","volume":"27","author":"Al-Dayel O","year":"2011","unstructured":"Al-Dayel O, Hefne J, Al-Ajyan T. Human exposure to heavy metal from cosmetics. Orient J Chem. 2011;27:1\u201311.","journal-title":"Orient J Chem"},{"key":"e_1_3_3_63_2","article-title":"Technical specification for cosmetic safety","author":"State Food and Drug Administration","year":"2015","unstructured":"State Food and Drug Administration. Technical specification for cosmetic safety. Beijing (China): Standards Press of China; 2015.","journal-title":"Beijing (China): Standards Press of China;"},{"key":"e_1_3_3_64_2","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202004182"},{"key":"e_1_3_3_65_2","unstructured":"Russell WMS Burch RLJM. The principles of humane experimental technique. 1959. https:\/\/onlinelibrary.wiley.com\/doi\/abs\/10.5694\/j.1326-5377.1960.tb73127.x"},{"key":"e_1_3_3_66_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells9071622"},{"key":"e_1_3_3_67_2","doi-asserted-by":"publisher","DOI":"10.1088\/1758-5090\/8\/3\/032001"},{"key":"e_1_3_3_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2021.112041"},{"key":"e_1_3_3_69_2","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-020-01365-7"},{"key":"e_1_3_3_70_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18040789"},{"key":"e_1_3_3_71_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.76.11.5665"},{"key":"e_1_3_3_72_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpm.2007.03.011"},{"key":"e_1_3_3_73_2","unstructured":"Stratatech reports positive interim clinical results for StrataGraft(r) skin substitute. J Biomedical Market Newsletter. 2012. https:\/\/www.meddeviceonline.com\/doc\/biomedical-market-newsletters-0001"},{"key":"e_1_3_3_74_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2015.12.039"},{"issue":"3","key":"e_1_3_3_75_2","article-title":"Preliminary discussion on the critical problems of skin tissue engineering","volume":"12","author":"Gang X","year":"2017","unstructured":"Gang X, Wu P, Weng T, et al. Preliminary discussion on the critical problems of skin tissue engineering. Chin J Injury Rep Wound Heal. 2017;12(3):164\u201368.","journal-title":"Chin J Injury Rep Wound Heal"},{"key":"e_1_3_3_76_2","doi-asserted-by":"publisher","DOI":"10.1098\/rsif.2006.0179"},{"key":"e_1_3_3_77_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature05664"},{"key":"e_1_3_3_78_2","doi-asserted-by":"publisher","DOI":"10.1586\/erd.11.27"},{"key":"e_1_3_3_79_2","doi-asserted-by":"publisher","DOI":"10.1038\/natrevmats.2016.71"},{"key":"e_1_3_3_80_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.7b00094"},{"key":"e_1_3_3_81_2","doi-asserted-by":"publisher","DOI":"10.3390\/polym9120638"},{"key":"e_1_3_3_82_2","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13725"},{"key":"e_1_3_3_83_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09168.x"},{"issue":"1","key":"e_1_3_3_84_2","article-title":"Lipid and ultrastructural characterization of reconstructed skin models","volume":"203","author":"Ponec M","year":"2000","unstructured":"Ponec M, Boelsma E, Weerheim A, Mulder A, Bouwstra J, Mommaas M. Lipid and ultrastructural characterization of reconstructed skin models. Int J Pharm. 2000;203(1):211\u201325.","journal-title":"Int J Pharm"},{"issue":"13","key":"e_1_3_3_85_2","article-title":"Deconstructing the third dimension: how 3D culture microenvironments alter cellular cues","volume":"125","author":"Baker BM","year":"2012","unstructured":"Baker BM, Chen CS. Deconstructing the third dimension: how 3D culture microenvironments alter cellular cues. J Cell Sci. 2012;125(Pt 13):3015\u201324.","journal-title":"J Cell Sci"},{"key":"e_1_3_3_86_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr000108x"},{"key":"e_1_3_3_87_2","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2018.00086"},{"key":"e_1_3_3_88_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-148X.2010.00786.x"},{"key":"e_1_3_3_89_2","doi-asserted-by":"publisher","DOI":"10.1177\/09636897231175968"},{"issue":"7","key":"e_1_3_3_90_2","article-title":"Establishment of human pluripotent stem cell-derived skin organoids enabled pathophysiological model of SARS-CoV-2 infection","volume":"9","author":"Ma J","year":"2022","unstructured":"Ma J, Liu J, Gao D, Li X, Zhang Q, Lv L, Wang Y, Li J, Zhu Y, Wu Z, Hu H, et al. Establishment of human pluripotent stem cell-derived skin organoids enabled pathophysiological model of SARS-CoV-2 infection. Adv Sci (Weinh). 2022;9(7):e2104192.","journal-title":"Adv Sci (Weinh)"},{"key":"e_1_3_3_91_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2022.04.008"},{"key":"e_1_3_3_92_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aaw2459"},{"key":"e_1_3_3_93_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22083849"},{"key":"e_1_3_3_94_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00020.2018"},{"key":"e_1_3_3_95_2","doi-asserted-by":"publisher","DOI":"10.1177\/09636897231190174"},{"key":"e_1_3_3_96_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abf0787"},{"key":"e_1_3_3_97_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.29302"},{"key":"e_1_3_3_98_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1901720117"},{"key":"e_1_3_3_99_2","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2022.1083459"},{"key":"e_1_3_3_100_2","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2008-0404OC"},{"key":"e_1_3_3_101_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.27073"},{"key":"e_1_3_3_102_2","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2022.913009"},{"key":"e_1_3_3_103_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2022.154449"},{"key":"e_1_3_3_104_2","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2017.6400"},{"key":"e_1_3_3_105_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13770-018-0118-x"},{"key":"e_1_3_3_106_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.15-275941"},{"key":"e_1_3_3_107_2","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12827"},{"key":"e_1_3_3_108_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2012.02501.x"},{"key":"e_1_3_3_109_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgm054"},{"key":"e_1_3_3_110_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2013.06.020"},{"key":"e_1_3_3_111_2","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2019.1021"},{"key":"e_1_3_3_112_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2017.00119"},{"issue":"4","key":"e_1_3_3_113_2","article-title":"2D and 3D cell cultures\u2014a comparison of different types of cancer cell cultures","volume":"14","author":"Kapa\u0142czy\u0144ska M","year":"2018","unstructured":"Kapa\u0142czy\u0144ska M, Kolenda T, Przyby\u0142a W, Zaj\u0105czkowska M, Teresiak A, Filas V, Ibbs M, Bli\u017aniak R, \u0141uczewski \u0141, Lamperska K. 2D and 3D cell cultures\u2014a comparison of different types of cancer cell cultures. Arch Med Sci. 2018;14(4):910\u201319.","journal-title":"Arch Med Sci"},{"key":"e_1_3_3_114_2","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0610374"},{"key":"e_1_3_3_115_2","doi-asserted-by":"publisher","DOI":"10.1089\/ten.2006.0405"},{"key":"e_1_3_3_116_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2013.417"},{"key":"e_1_3_3_117_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2011.01383.x"},{"key":"e_1_3_3_118_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222112035"},{"key":"e_1_3_3_119_2","doi-asserted-by":"publisher","DOI":"10.1002\/sctm.19-0319"},{"key":"e_1_3_3_120_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c05557"},{"key":"e_1_3_3_121_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.36723"},{"key":"e_1_3_3_122_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2022.05.021"},{"key":"e_1_3_3_123_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2022.10.003"},{"key":"e_1_3_3_124_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2021.11.037"},{"key":"e_1_3_3_125_2","doi-asserted-by":"publisher","DOI":"10.1093\/rb\/rbad060"},{"key":"e_1_3_3_126_2","doi-asserted-by":"publisher","DOI":"10.1088\/1758-5090\/ac1259"},{"key":"e_1_3_3_127_2","doi-asserted-by":"publisher","DOI":"10.1002\/glia.23892"},{"key":"e_1_3_3_128_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2022.105952"},{"key":"e_1_3_3_129_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-020-01924-z"},{"key":"e_1_3_3_130_2","doi-asserted-by":"publisher","DOI":"10.7717\/peerj-cs.1387"},{"key":"e_1_3_3_131_2","doi-asserted-by":"crossref","unstructured":"Niu H Li H Zhang Q Kim ES Kim NY Li Y. Intuition-and-tactile bimodal sensing based on artificial-intelligence-motivated all-fabric bionic electronic skin for intelligent material perception. Small. 2023. https:\/\/doi.org\/10.1002\/smll.202308127 [accessed 2023 Nov 27].","DOI":"10.1002\/smll.202308127"},{"key":"e_1_3_3_132_2","doi-asserted-by":"publisher","DOI":"10.34133\/2022\/9867378"},{"key":"e_1_3_3_133_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23158589"},{"key":"e_1_3_3_134_2","doi-asserted-by":"publisher","DOI":"10.1177\/02611929211029635"},{"key":"e_1_3_3_135_2","doi-asserted-by":"publisher","DOI":"10.1159\/000066682"},{"key":"e_1_3_3_136_2","doi-asserted-by":"publisher","DOI":"10.1177\/026119290603400312"},{"key":"e_1_3_3_137_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2009.05.018"},{"key":"e_1_3_3_138_2","volume-title":"Study of several alternative experimental methods for dermal toxicity in cosmetic safety evaluation","author":"Liu Z","year":"2009","unstructured":"Liu Z. Study of several alternative experimental methods for dermal toxicity in cosmetic safety evaluation. Master\u2019s thesis. The Second Military Medical University of the Chinese People\u2019s Liberation Army; 2009."},{"key":"e_1_3_3_139_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2013.06.004"},{"key":"e_1_3_3_140_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2494.2009.00499.x"},{"key":"e_1_3_3_141_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2009.09.019"},{"key":"e_1_3_3_142_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2011.01319.x"},{"issue":"3","key":"e_1_3_3_143_2","article-title":"The sun protection factor (SPF) inadequately defines broad spectrum photoprotection: demonstration using skin reconstructed in vitro exposed to UVA, UVBor UV-solar simulated radiation","volume":"13","author":"Bernerd F","year":"2003","unstructured":"Bernerd F, Vioux C, Lejeune F, Asselineau D. The sun protection factor (SPF) inadequately defines broad spectrum photoprotection: demonstration using skin reconstructed in vitro exposed to UVA, UVBor UV-solar simulated radiation. Eur J Dermatol. 2003;13(3):242\u201349.","journal-title":"Eur J Dermatol"},{"key":"e_1_3_3_144_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0625.12.s2.10.x"},{"key":"e_1_3_3_145_2","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12020"},{"key":"e_1_3_3_146_2","unstructured":"Organisation for Economic Co-Operation and Development. Test no. 431: in vitro skin corrosion: reconstructed human epidermis (RhE) test method; 2019. https:\/\/www.oecd-ilibrary.org\/docserver\/9789264264618-en.Pdf?expires=1708487125&id=id&accname=guest&checksum=9BCED2243DD20097A470DD76A816570A [accessed 2024 Feb 21]."},{"key":"e_1_3_3_147_2","unstructured":"Organisation for Economic Co-Operation and Development. Test no. 439: in vitro skin irritation: reconstructed human epidermis test method; 2021. https:\/\/www.oecd-ilibrary.org\/docserver\/9789264242845-en.Pdf?expires=1708487240&id=id&accname=guest&checksum=D10AE7281BF34913EF46C281B34D9046 [accessed 2024 Feb 21]."},{"key":"e_1_3_3_148_2","unstructured":"Organisation for Economic Co-Operation and Development. Test no. 435: in vitro membrane barrier test method for skin corrosion; 2015. https:\/\/www.oecd.org\/env\/test-no-435-in-vitro-membrane-barrier-test-method-for-skin-corrosion-9789264242791-en.htm"},{"key":"e_1_3_3_149_2","doi-asserted-by":"crossref","unstructured":"Hartung T. Statement on the validity of in vitro tests for skin irritation. European Centre for the Validation of Alternative Methods; 2007. https:\/\/cordis.europa.eu\/project\/id\/2549","DOI":"10.1016\/j.toxlet.2007.05.061"},{"key":"e_1_3_3_150_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2004.08.004"},{"key":"e_1_3_3_151_2","doi-asserted-by":"publisher","DOI":"10.1080\/15569520701622993"},{"key":"e_1_3_3_152_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0887-2333(99)00076-4"},{"key":"e_1_3_3_153_2","doi-asserted-by":"publisher","DOI":"10.1016\/0887-2333(94)90195-3"},{"key":"e_1_3_3_154_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms16035517"},{"key":"e_1_3_3_155_2","doi-asserted-by":"publisher","DOI":"10.2174\/1381612824666180404152304"},{"key":"e_1_3_3_156_2","doi-asserted-by":"publisher","DOI":"10.3892\/or.2015.3767"},{"key":"e_1_3_3_157_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiotec.2005.12.021"},{"key":"e_1_3_3_158_2","doi-asserted-by":"publisher","DOI":"10.1080\/17425255.2019.1694662"},{"key":"e_1_3_3_159_2","doi-asserted-by":"publisher","DOI":"10.1177\/026119291504300607"},{"key":"e_1_3_3_160_2","doi-asserted-by":"publisher","DOI":"10.14573\/altex.1807041"},{"key":"e_1_3_3_161_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.12.007"},{"key":"e_1_3_3_162_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep00424"},{"key":"e_1_3_3_163_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1181"},{"key":"e_1_3_3_164_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00005.2017"},{"key":"e_1_3_3_165_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature05766"},{"key":"e_1_3_3_166_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1004687"},{"key":"e_1_3_3_167_2","article-title":"Generation of 3D skin organoid from cord blood-derived induced pluripotent stem cells","volume":"146","author":"Kim Y","year":"2019","unstructured":"Kim Y, Ju JH. Generation of 3D skin organoid from cord blood-derived induced pluripotent stem cells. J Vis Exp. 2019;146:e59297.","journal-title":"J Vis Exp"},{"key":"e_1_3_3_168_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10544-017-0156-5"},{"key":"e_1_3_3_169_2","doi-asserted-by":"publisher","DOI":"10.1039\/c3lc50227a"},{"key":"e_1_3_3_170_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaw7894"},{"key":"e_1_3_3_171_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12015-017-9737-1"},{"key":"e_1_3_3_172_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241612537"}],"container-title":["Cell Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09636897241235464","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/09636897241235464","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09636897241235464","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:39:57Z","timestamp":1777390797000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/09636897241235464"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,16]]},"references-count":171,"alternative-id":["10.1177\/09636897241235464"],"URL":"https:\/\/doi.org\/10.1177\/09636897241235464","relation":{},"ISSN":["0963-6897","1555-3892"],"issn-type":[{"value":"0963-6897","type":"print"},{"value":"1555-3892","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,16]]},"article-number":"09636897241235464"}}