{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T13:20:08Z","timestamp":1790083208912,"version":"4.0.1"},"reference-count":26,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T00:00:00Z","timestamp":1742256000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T00:00:00Z","timestamp":1742256000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"The Project for Technology Development of Beijing-affiliated Medical Research Institutes","award":["11000023T000002036310"],"award-info":[{"award-number":["11000023T000002036310"]}]},{"name":"Beijing Hospitals Authority's Ascent Plan","award":["DFL20240804"],"award-info":[{"award-number":["DFL20240804"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171250"],"award-info":[{"award-number":["82171250"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Hui Zhi talent project","award":["HZ2021ZCLJ004"],"award-info":[{"award-number":["HZ2021ZCLJ004"]}]},{"DOI":"10.13039\/501100005089","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["7242068"],"award-info":[{"award-number":["7242068"]}],"id":[{"id":"10.13039\/501100005089","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cell Transplant"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:p>\n                    Cell transplantation is a promising approach for addressing neurodegenerative conditions. In this study, we developed a robot-assisted stereotactic microinjection system for transplanting cells. We evaluated the factors that affect cellular graft viability and other properties, including the gauge of the syringe needle and the injection rate. We systematically compared the synchronous withdrawal injection (SWI) and fixed-point injection (FPI) procedures in agarose and rat brain models.\n                    <jats:italic toggle=\"yes\">In vitro<\/jats:italic>\n                    assessments revealed superior dye dispersion with SWI compared to FPI, and\n                    <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                    analyses confirmed that SWI reduced the tissue injury and improved cell distribution in the striatum. We applied this robot-assisted technique to evaluate the accuracy and safety of cell transplantation in canine models. Overall, this strategy enhances the accuracy and safety of graft delivery, potentially improving outcomes and advancing therapeutic strategies for the clinical treatment of neurodegenerative disorders.\n                  <\/jats:p>","DOI":"10.1177\/09636897251323351","type":"journal-article","created":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T01:01:46Z","timestamp":1742346106000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Robot-Assisted Stereotactic Microinjection Method for Precision Cell Transplantation in Rat and Canine Models"],"prefix":"10.1177","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8187-0355","authenticated-orcid":false,"given":"Deqiang","family":"Han","sequence":"first","affiliation":[{"name":"Cell Therapy Center, Beijing Municipal Geriatric Medical Research Center, National Clinical Research Center for Geriatric Diseases, and Key Laboratory of Neurodegenerative Diseases, Ministry of Education, Xuanwu Hospital Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sichang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Xuanwu Hospital Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Cell Therapy Center, Beijing Municipal Geriatric Medical Research Center, National Clinical Research Center for Geriatric Diseases, and Key Laboratory of Neurodegenerative Diseases, Ministry of Education, Xuanwu Hospital Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueyao","family":"Wang","sequence":"additional","affiliation":[{"name":"Cell Therapy Center, Beijing Municipal Geriatric Medical Research Center, National Clinical Research Center for Geriatric Diseases, and Key Laboratory of Neurodegenerative Diseases, Ministry of Education, Xuanwu Hospital Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingzhe","family":"Wang","sequence":"additional","affiliation":[{"name":"Cell Therapy Center, Beijing Municipal Geriatric Medical Research Center, National Clinical Research Center for Geriatric Diseases, and Key Laboratory of Neurodegenerative Diseases, Ministry of Education, Xuanwu Hospital Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianqi","family":"Zheng","sequence":"additional","affiliation":[{"name":"Cell Therapy Center, Beijing Municipal Geriatric Medical Research Center, National Clinical Research Center for Geriatric Diseases, and Key Laboratory of Neurodegenerative Diseases, Ministry of Education, Xuanwu Hospital Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1508-510X","authenticated-orcid":false,"given":"Zhiguo","family":"Chen","sequence":"additional","affiliation":[{"name":"Cell Therapy Center, Beijing Municipal Geriatric Medical Research Center, National Clinical Research Center for Geriatric Diseases, and Key Laboratory of Neurodegenerative Diseases, Ministry of Education, Xuanwu Hospital Capital Medical University, Beijing, China"},{"name":"Center of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing, China"},{"name":"Center of Parkinson\u2019s Disease, Beijing Institute for Brain Disorders, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,3,18]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-220721"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2023.03.017"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41583-019-0257-7"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awae204"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1915872"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnrt.2024.100136"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnrt.2023.100055"},{"key":"e_1_3_3_9_2","first-page":"83","article-title":"Clinical considerations in Parkinson\u2019s disease cell therapy","author":"Xue J","year":"2023","unstructured":"Xue J, Wu Y, Bao Y, Zhao M, Li F, Sun J, Sun Y, Wang J, Chen L, Mao Y, Schweitzer JS, et al. Clinical considerations in Parkinson\u2019s disease cell therapy. Ageing Res Rev. 2023;83.","journal-title":"Ageing Res Rev"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2011.11.002"},{"key":"e_1_3_3_11_2","article-title":"Drug delivery pathways to the central nervous system via the brain glymphatic system circumventing the blood-brain barrier","author":"Wang X","unstructured":"Wang X, Yin Y, Zhou H, Chi B, Guan L, Li P, Li J, Wang Y. Drug delivery pathways to the central nervous system via the brain glymphatic system circumventing the blood-brain barrier. Exploration. 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Human neural progenitor cells retain viability, phenotype, proliferation, and lineage differentiation when labeled with a novel iron oxide nanoparticle, Molday ION Rhodamine B. Int J Nanomedicine. 2013;8:4593\u20134600.","journal-title":"Int J Nanomedicine"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.7150\/thno.80271"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.7150\/thno.26643"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.scib.2023.10.020"},{"key":"e_1_3_3_24_2","article-title":"Devices for cell transplantation into the central nervous system: design considerations and emerging technologies","volume":"4","author":"Potts MB","year":"2013","unstructured":"Potts MB, Silvestrini MT, Lim DA. Devices for cell transplantation into the central nervous system: design considerations and emerging technologies. 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