{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T20:28:05Z","timestamp":1791836885333,"version":"4.3.4"},"reference-count":55,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T00:00:00Z","timestamp":1743033600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T00:00:00Z","timestamp":1743033600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cell Transplant"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:p>\n                    This study aimed to investigate the impact of human umbilical cord\u2013derived mesenchymal stromal cells (hUC-MSCs) on food allergy (FA) mice induced by ovalbumin. The percentage of regulatory T cells (Tregs) was assessed by administering hUC-MSCs intravenously to FA mouse models with oral challenges, allergic responses and levels of related allergic cytokines. The phenotypes of hUC-MSCs were analysed using flow cytometric analysis. Immunohistochemistry was used for histology observation. Real-time polymerase chain reaction (PCR) was used for gene expression. Jejunum tissue was analysed by transcriptome sequencing. Our results demonstrated that in the current FA model, hUC-MSC therapy significantly alleviated allergic responses and diarrhoea. Levels of immunoglobulin E (IgE), as well as cytokines, such as interleukin (IL)-6 and tumour necrosis factor-\u03b1 associated with T helper 2 cells, were reduced. Conversely, transforming growth factor (TGF)-\u03b2 levels increased with hUC-MSC therapy. In addition, enhanced TGF-\u03b2 expression along with IL-10 messenger ribonucleic acid levels and an increased percentage of CD4\n                    <jats:sup>+<\/jats:sup>\n                    Foxp3\n                    <jats:sup>+<\/jats:sup>\n                    Tregs were observed. In long-term FA mice models, hUC-MSC therapy exhibited sustained effects in mitigating rectal temperature decrease and mortality rates while reducing the levels of IgE, IL-6 and proportion of IgE+ cells; it also elevated TGF-\u03b2 levels. Furthermore, hUC-MSC therapy attenuated pathological injury in both current and long-term FA mouse models. Transcriptome sequencing showed that upregulated differentially expressed genes were mainly concentrated in neural activation\u2013ligand interaction, the cyclic guanosine monophosphate\u2013protein kinase G signalling pathway and the TGF-\u03b2 signalling pathway. The hUC-MSC therapy holds promise for alleviating both immediate and persistent FA conditions; targeting TGF-\u03b2 and IL-10 secreted by hUC-MSCs may be a potential approach for treating FA.\n                  <\/jats:p>","DOI":"10.1177\/09636897251326899","type":"journal-article","created":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T08:36:17Z","timestamp":1743064577000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Therapeutic and continuative effects of human umbilical cord\u2013derived mesenchymal stromal cells in food-allergic mice"],"prefix":"10.1177","volume":"34","author":[{"given":"Yuan","family":"Zhao","sequence":"first","affiliation":[{"name":"The Second School of Clinical Medicine, Southern Medical University, Guangzhou, China"},{"name":"Department of Pediatrics, The Sixth Medical Center of PLA General Hospital, Beijing, China"},{"name":"Department of Neonatology, Children\u2019s Hospital of Shanxi, Women Health Center of Shanxi, Taiyuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yabing","family":"Ding","sequence":"additional","affiliation":[{"name":"The Second School of Clinical Medicine, Southern Medical University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoyan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The Sixth Medical Center of PLA General Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The Sixth Medical Center of PLA General Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dou","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The Sixth Medical Center of PLA General Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3544-6772","authenticated-orcid":false,"given":"Zuo","family":"Luan","sequence":"additional","affiliation":[{"name":"The Second School of Clinical Medicine, Southern Medical University, Guangzhou, China"},{"name":"Department of Pediatrics, The Sixth Medical Center of PLA General Hospital, Beijing, China"},{"name":"Department of Pediatrics, The Second School of Clinical Medicine, Southern Medical University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,3,27]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1159\/000525961"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.11.003"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2022.11328"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.03.023"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2015.05.010"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1159\/000511239"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.98"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/all.13404"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-018-8669-0"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.06.003"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.3390\/medicina55100684"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.33549\/physiolres.934892"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.2217\/imt-2019-0194"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10020511"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.3727\/096368915X686841"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2008.0393"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-61779-815-3_17"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2024.117120"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1159\/000445433"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2018.05.010"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/all.12650"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.3109\/08923973.2012.745871"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2018.01.011"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2018.6763"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1005-4847"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.01.021"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.4014\/jmb.1708.08051"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-019-1478-4"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-23396-1"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2012.09.024"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.7150\/thno.45434"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.a.23242"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.692004"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.3390\/medicina56030111"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.11.032"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep04649"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.888949"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13770-021-00395-4"},{"issue":"6","key":"e_1_3_2_40_2","article-title":"Food allergy: diagnosis, management & emerging therapies","volume":"139","author":"Robison RG","year":"2014","unstructured":"Robison RG. Food allergy: diagnosis, management & emerging therapies. Indian J Med Res. 2014;139(6):805\u201313.","journal-title":"Indian J Med Res"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.4014\/jmb.2106.06037"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2017.12.021"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-017-0600-8"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.20668"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2008.0253"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-020-02912-y"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.122.059062"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.3791\/55224"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.29572"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2021.101322"},{"issue":"2","key":"e_1_3_2_51_2","article-title":"Latest findings on the placenta from the point of view of immunology, tolerance and mesenchymal stem cells","volume":"84","author":"Macholdov\u00e1 K","year":"2019","unstructured":"Macholdov\u00e1 K, Mach\u00e1\u010dkov\u00e1 E, Pro\u0161kov\u00e1 V, Hromadn\u00edkov\u00e1 I, Klubal R. Latest findings on the placenta from the point of view of immunology, tolerance and mesenchymal stem cells. Ceska Gynekol. 2019;84(2):154\u201360.","journal-title":"Ceska Gynekol"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2008.055277"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-021-00610-y"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2012.11.053"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2013.12.010"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2017.05.010"}],"container-title":["Cell Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09636897251326899","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/09636897251326899","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09636897251326899","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:36:09Z","timestamp":1777390569000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/09636897251326899"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,27]]},"references-count":55,"alternative-id":["10.1177\/09636897251326899"],"URL":"https:\/\/doi.org\/10.1177\/09636897251326899","relation":{},"ISSN":["0963-6897","1555-3892"],"issn-type":[{"value":"0963-6897","type":"print"},{"value":"1555-3892","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,27]]},"article-number":"09636897251326899"}}