{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T22:46:52Z","timestamp":1791413212137,"version":"4.3.3"},"reference-count":34,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T00:00:00Z","timestamp":1750809600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T00:00:00Z","timestamp":1750809600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170210"],"award-info":[{"award-number":["82170210"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFA1103500"],"award-info":[{"award-number":["2022YFA1103500"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cell Transplant"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:p>\n                    Obesity is a well-known risk factor for many diseases, but the impact of baseline body mass index (BMI) on the outcomes of allogeneic hematopoietic stem cell transplantation (allo-HSCT) remains controversial. To elucidate the influence of pretransplant BMI on post-allo-HSCT outcomes including graft-versus-host disease (GVHD), overall survival (OS), relapse-free survival (RFS), and nonrelapse mortality (NRM), we conducted a retrospective study using registry data which comprised 1092 adult patients who underwent allo-HSCT between 2015 and 2023. Among the 1092 eligible patients (53.2% male), 56.5% were normal-weight; 24.8% were overweight and 9.1% were obese. Multivariable analyses revealed that compared with normal-weight patients, obese individuals had a higher risk of grade II\u2013IV and III\u2013IV acute GVHD (aGVHD), especially in the gastrointestinal system, with aHRs of 2.08 (95% CI, 1.47\u20132.94), 2.60 (95% CI, 1.52\u20134.44), and 3.71 (95% CI, 2.00\u20136.88), respectively. The probability of OS and RFS was significantly lower in overweight (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.034,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.015, respectively) and obese patients (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.033,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.024, respectively) as compared with normal-weight patients, with aHRs increasing by ~38% (aHR, 1.38; 95% CI, 1.03\u20131.86), ~40% (aHR, 1.40; 95% CI, 1.07\u20131.83), ~58% (aHR, 1.58; 95% CI, 1.04\u20132.40), and ~56% (aHR, 1.56; 95% CI, 1.06\u20132.29), respectively. Furthermore, the NRM of obese patients was statistically higher than normal-weight patients (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.02, sHR, 2.19; 95% CI, 1.12\u20134.27). A subgroup analysis revealed that the adverse effects of obesity on OS, RFS, and NRM were primarily observed in the subgroup of patients aged &lt; 40 years and patients with acute lymphoblastic leukemia. The increased risk of grade II\u2013IV aGVHD due to obesity was observed across all subgroups. In conclusion, Obesity prior to allo-HSCT increases the risk of aGVHD and NRM, leading to poorer OS. These findings underscore the importance of closely monitoring high-risk patients and offering opportunities for early intervention.\n                  <\/jats:p>","DOI":"10.1177\/09636897251349377","type":"journal-article","created":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T11:50:42Z","timestamp":1750852242000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Prognostic effect of body mass index in patients with acute leukemia undergoing allogeneic hematopoietic stem cell transplantation: A retrospective cohort study"],"prefix":"10.1177","volume":"34","author":[{"given":"Jing","family":"Yu","sequence":"first","affiliation":[{"name":"School of Medicine, Zhejiang University, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuoyue","family":"Shi","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China"},{"name":"Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou, China"},{"name":"Institute of Hematology, Zhejiang University, Hangzhou, China"},{"name":"Zhejiang Province Engineering Laboratory for Stem Cell and Immunity Therapy, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hengwei","family":"Wu","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China"},{"name":"Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou, China"},{"name":"Institute of Hematology, Zhejiang University, Hangzhou, China"},{"name":"Zhejiang Province Engineering Laboratory for Stem Cell and Immunity Therapy, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Luo","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China"},{"name":"Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou, China"},{"name":"Institute of Hematology, Zhejiang University, Hangzhou, China"},{"name":"Zhejiang Province Engineering Laboratory for Stem Cell and Immunity Therapy, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Yu","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China"},{"name":"Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou, China"},{"name":"Institute of Hematology, Zhejiang University, Hangzhou, China"},{"name":"Zhejiang Province Engineering Laboratory for Stem Cell and Immunity Therapy, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yamin","family":"Tan","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Lai","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China"},{"name":"Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou, China"},{"name":"Institute of Hematology, Zhejiang University, Hangzhou, China"},{"name":"Zhejiang Province Engineering Laboratory for Stem Cell and Immunity Therapy, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lizhen","family":"Liu","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China"},{"name":"Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou, China"},{"name":"Institute of Hematology, Zhejiang University, Hangzhou, China"},{"name":"Zhejiang Province Engineering Laboratory for Stem Cell and Immunity Therapy, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huarui","family":"Fu","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China"},{"name":"Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou, China"},{"name":"Institute of Hematology, Zhejiang University, Hangzhou, China"},{"name":"Zhejiang Province Engineering Laboratory for Stem Cell and Immunity Therapy, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yishan","family":"Ye","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China"},{"name":"Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou, China"},{"name":"Institute of Hematology, Zhejiang University, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luxin","family":"Yang","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China"},{"name":"Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou, China"},{"name":"Institute of Hematology, Zhejiang University, Hangzhou, China"},{"name":"Zhejiang Province Engineering Laboratory for Stem Cell and Immunity Therapy, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Congxiao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Huang","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China"},{"name":"Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou, China"},{"name":"Institute of Hematology, Zhejiang University, Hangzhou, China"},{"name":"Zhejiang Province Engineering Laboratory for Stem Cell and Immunity Therapy, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jimin","family":"Shi","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China"},{"name":"Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou, China"},{"name":"Institute of Hematology, Zhejiang University, Hangzhou, China"},{"name":"Zhejiang Province 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