{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T14:06:03Z","timestamp":1781359563983,"version":"3.54.1"},"reference-count":24,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cell Transplant"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:p>\n                    The impact of early tacrolimus (TAC) blood levels on acute graft-versus-host disease (aGVHD) and transplant outcomes in adults undergoing haploidentical hematopoietic stem cell transplantation (haplo-HSCT) with posttransplant cyclophosphamide (PTCy) is incompletely investigated. We retrospectively analyzed 161 T-cell\u2013replete haplo-HSCT with PTCy, TAC, and mycophenolate-mofetil. TAC trough levels from weeks 1\u20132 (w1\/2) and weeks 3\u20134 (w3\/4) posttransplant were categorized as \u201cLow\u201d or \u201cHigh\u201d using a threshold of 10 ng\/ml. Outcomes assessed included grade III\u2013IV acute graft-versus-host-disease (aGVHD), nonrelapse mortality (NRM), relapse, and overall survival (OS). Multivariate analyses controlled for relevant patient and transplant factors. Higher w1\/2 TAC (\u226510 ng\/ml) in weeks 1\u20132 had no association with aGVHD III\/IV (35% vs. 35%,\n                    <jats:italic>P<\/jats:italic>\n                    = 0.71). Higher TAC levels during w3\/4 were associated with a trend toward decreased aGVHD III\u2013IV incidence (8% vs. 20%;\n                    <jats:italic>P<\/jats:italic>\n                    = 0.09). Multivariate analysis confirmed w3\/4 TAC levels as protective against aGVHD III\/IV (sub-Hazard Ratio [sHR] = 0.83, 95% CI: 0.70\u20130.98,\n                    <jats:italic>P<\/jats:italic>\n                    = 0.03) and NRM (sHR = 0.82, 95% CI: 0.71\u20130.95,\n                    <jats:italic>P<\/jats:italic>\n                    = 0.01), while w1\/2 TAC levels had no significant impact on the above outcomes. TAC levels did not significantly impact OS or relapse. We conclude that following PTCy-based haplo-HSCT, higher TAC levels during weeks 3\u20134 may decrease aGVHD and NRM.\n                  <\/jats:p>","DOI":"10.1177\/09636897251366368","type":"journal-article","created":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T08:52:59Z","timestamp":1755161579000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["The impact of tacrolimus levels on acute GVHD and transplant outcomes in haploidentical hematopoietic stem cell transplantation: A retrospective analysis"],"prefix":"10.1177","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5713-6257","authenticated-orcid":false,"given":"Alexander","family":"Nikoloudis","sequence":"first","affiliation":[{"name":"Department of Internal Medicine I: Hematology with Stem Cell Transplantation, Hemostaseology and Medical Oncology, Ordensklinikum Linz Elisabethinen, Linz, Austria"},{"name":"Faculty of Medicine, Johannes Kepler University Linz, Linz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronika","family":"Buxhofer-Ausch","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I: Hematology with Stem Cell Transplantation, Hemostaseology and Medical Oncology, Ordensklinikum Linz Elisabethinen, Linz, Austria"},{"name":"Faculty of Medicine, Johannes Kepler University Linz, Linz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ameya","family":"Kunte","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I: Hematology with Stem Cell Transplantation, Hemostaseology and Medical Oncology, Ordensklinikum Linz Elisabethinen, Linz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Groiss","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I: Hematology with Stem Cell Transplantation, Hemostaseology and Medical Oncology, Ordensklinikum Linz Elisabethinen, Linz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenz","family":"Mair","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I: Hematology with Stem Cell Transplantation, Hemostaseology and Medical Oncology, Ordensklinikum Linz Elisabethinen, Linz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Aichinger","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I: Hematology with Stem Cell Transplantation, Hemostaseology and Medical Oncology, Ordensklinikum Linz Elisabethinen, Linz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michaela","family":"Binder","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I: Hematology with Stem Cell Transplantation, Hemostaseology and Medical Oncology, Ordensklinikum Linz Elisabethinen, Linz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Hasengruber","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I: Hematology with Stem Cell Transplantation, Hemostaseology and Medical Oncology, Ordensklinikum Linz Elisabethinen, Linz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emine","family":"Kaynak","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I: Hematology with Stem Cell Transplantation, Hemostaseology and Medical Oncology, Ordensklinikum Linz Elisabethinen, Linz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dagmar","family":"Wipplinger","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I: Hematology with Stem Cell Transplantation, Hemostaseology and Medical Oncology, Ordensklinikum Linz Elisabethinen, Linz, 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Austria"},{"name":"Faculty of Medicine, Johannes Kepler University Linz, Linz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigrid","family":"Machherndl-Spandl","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I: Hematology with Stem Cell Transplantation, Hemostaseology and Medical Oncology, Ordensklinikum Linz Elisabethinen, Linz, Austria"},{"name":"Faculty of Medicine, Johannes Kepler University Linz, Linz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger","family":"Rumpold","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I: Hematology with Stem Cell Transplantation, Hemostaseology and Medical Oncology, Ordensklinikum Linz Elisabethinen, Linz, Austria"},{"name":"Faculty of Medicine, Johannes Kepler University Linz, Linz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ansgar","family":"Weltermann","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I: Hematology with Stem Cell Transplantation, Hemostaseology and Medical Oncology, Ordensklinikum Linz Elisabethinen, Linz, Austria"},{"name":"Faculty of Medicine, Johannes Kepler University Linz, Linz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Petzer","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I: Hematology with Stem Cell Transplantation, Hemostaseology and Medical Oncology, Ordensklinikum Linz Elisabethinen, Linz, Austria"},{"name":"Faculty of Medicine, Johannes Kepler University Linz, Linz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Clausen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I: Hematology with Stem Cell Transplantation, 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