{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:48:15Z","timestamp":1777510095901,"version":"3.51.4"},"reference-count":35,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170205"],"award-info":[{"award-number":["82170205"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cell Transplant"],"published-print":{"date-parts":[[2026,2]]},"abstract":"\n NPM1<\/jats:italic>\n -mutated acute myeloid leukemia (AML) is a distinct entity with specific biological and clinicopathological features. Prognosis varies depending on the associated mutations and clinical characteristics. This study evaluated the prognostic factors of\n NPM1<\/jats:italic>\n -mutated AML in patients who underwent allogeneic hematopoietic stem cell transplantation (allo-HSCT). We enrolled 139 patients with\n NPM1<\/jats:italic>\n -mutated AML who underwent allo-HSCT. The median age at allo-HSCT was 47 years with a median follow-up of 1,134 days. The 3-year cumulative incidence of relapse (CIR), leukemia-free survival (LFS), and overall survival (OS) rates were 15.1%, 78.4%, and 78.0%, respectively.\n FLT3-ITD<\/jats:italic>\n mutations showed higher CIR (22.6% vs 5.3%,\n P<\/jats:italic>\n = 0.006), lower LFS (70.9% vs 88.1%,\n P<\/jats:italic>\n = 0.019), and reduced OS (70.8% vs 87.5%,\n P<\/jats:italic>\n = 0.036).\n FLT3-ITD<\/jats:italic>\n and DTA mutations indicated adverse prognosis, while\n IDH1\/2<\/jats:italic>\n mutations showed improved outcomes. Matched sibling donor (MSD) allo-HSCT patients had higher CIR and lower LFS and OS than unrelated donor (URD) or haploidentical-related donor (HRD) recipients. Pre-HSCT MRD status affected the outcomes, with MRD+ and nCR patients showing worse outcomes. Multivariable analysis identified\n FLT3-ITD<\/jats:italic>\n , MSD, and pre-MRD status as significant predictors. In conclusion,\n FLT3-ITD<\/jats:italic>\n and DTA mutations are associated with an adverse prognosis, whereas HRD or URD transplants may offer better outcomes than MSD allo-HSCT.\n <\/jats:p>","DOI":"10.1177\/09636897251414205","type":"journal-article","created":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T02:40:37Z","timestamp":1770950437000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Prognostic impact of clinico-genetic characteristics and donor types in\n NPM1<\/i>\n -mutated AML undergoing allogeneic hematopoietic stem cell transplantation"],"prefix":"10.1177","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-9384-5967","authenticated-orcid":false,"given":"Xiaolin","family":"Yuan","sequence":"first","affiliation":[{"name":"Bone Marrow Transplantation Center, The First Affiliated Hospital and Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, China"},{"name":"Department of Hematology, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yibo","family":"Wu","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Center, The First Affiliated Hospital and Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, China"},{"name":"Institute of Hematology, Zhejiang University, Hangzhou, China"},{"name":"Zhejiang Province Engineering Research Center for Stem Cell and Immunity Therapy, Hangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tingting","family":"Yang","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Center, The First Affiliated Hospital and Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, China"},{"name":"Institute of Hematology, Zhejiang University, Hangzhou, China"},{"name":"Zhejiang Province Engineering Research Center for Stem Cell and Immunity Therapy, Hangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Panpan","family":"Zhu","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Center, The First Affiliated Hospital and Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, China"},{"name":"Institute of Hematology, Zhejiang University, Hangzhou, China"},{"name":"Zhejiang Province Engineering Research Center for Stem Cell and Immunity Therapy, Hangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyu","family":"Lai","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Center, The First Affiliated Hospital and Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, China"},{"name":"Institute of Hematology, Zhejiang University, Hangzhou, China"},{"name":"Zhejiang Province Engineering Research Center for Stem Cell and Immunity Therapy, Hangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lizhen","family":"Liu","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Center, The First Affiliated Hospital and Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, China"},{"name":"Institute of Hematology, Zhejiang University, Hangzhou, China"},{"name":"Zhejiang Province Engineering Research Center for Stem Cell and Immunity Therapy, Hangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luxin","family":"Yang","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Center, The First Affiliated Hospital and Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, China"},{"name":"Institute of Hematology, Zhejiang University, Hangzhou, China"},{"name":"Zhejiang Province Engineering Research Center for Stem Cell and Immunity Therapy, Hangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jimin","family":"Shi","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Center, The First Affiliated Hospital and Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, China"},{"name":"Institute of Hematology, Zhejiang University, Hangzhou, China"},{"name":"Zhejiang Province Engineering Research Center for Stem Cell and Immunity Therapy, Hangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Yu","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Center, The First Affiliated Hospital and Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, China"},{"name":"Institute of Hematology, Zhejiang University, Hangzhou, China"},{"name":"Zhejiang Province Engineering Research Center for Stem Cell and Immunity Therapy, Hangzhou, 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China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Sun","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Center, The First Affiliated Hospital and Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, China"},{"name":"Institute of Hematology, Zhejiang University, Hangzhou, China"},{"name":"Zhejiang Province Engineering Research Center for Stem Cell and Immunity Therapy, Hangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjun","family":"Wu","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Center, The First Affiliated Hospital and Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, China"},{"name":"Institute of Hematology, Zhejiang University, Hangzhou, China"},{"name":"Zhejiang Province Engineering Research Center for Stem Cell and Immunity Therapy, Hangzhou, 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