{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T14:24:31Z","timestamp":1779114271201,"version":"3.51.4"},"reference-count":51,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Basic project of Science and Technology Department of Guizhou Province","award":["ZK[2022]-145"],"award-info":[{"award-number":["ZK[2022]-145"]}]},{"name":"Health Commission of Guizhou Province Scientific Research Project","award":["gzwkj 2022-136"],"award-info":[{"award-number":["gzwkj 2022-136"]}]},{"name":"project for Ministry of Education on Birth Defects and Related Maternal and Child Diseases","award":["2025KF03"],"award-info":[{"award-number":["2025KF03"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cell Transplant"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:p>\n                    To address the lack of effective treatments for germinal matrix hemorrhage-intraventricular hemorrhage (GMH-IVH), a devastating condition in preterm infants with poor prognosis, this study investigated the neuroprotective potential and underlying mechanism of human umbilical cord-derived mesenchymal stem cells (HUCMSCs). Using a collagenase VII-S-induced GMH neonatal rat model and lipopolysaccharide-stimulated BV2 microglial cells,\n                    <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    experiments were performed.\n                    <jats:italic toggle=\"yes\">In vivo<\/jats:italic>\n                    results showed that intraventricular HUCMSCs administration alleviated cerebral injury (reduced ventricular enlargement and cortical damage) and improved motor, memory, and cognitive functions in GMH rats. Both HUCMSCs and MSC-conditioned medium (MSC-CM) modulated microglial polarization toward the pro-resolving phenotype, suppressed pro-inflammatory polarization, and decreased\n                    <jats:italic toggle=\"yes\">TNF-\u03b1<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">IL-6<\/jats:italic>\n                    expression. Mechanistically, MSCs downregulated ROCK2 protein levels; the ROCK agonist PA abrogated MSC-CM\u2019s anti-inflammatory effects, while the ROCK inhibitor Y27632 mimicked MSC-CM\u2019s pro-M2 polarization. Collectively, this study demonstrates that HUCMSCs exert neuroprotection against GMH by suppressing ROCK2 to regulate microglial polarization, thereby mitigating neuroinflammation and promoting nerve repair, highlighting MSCs as a promising therapeutic strategy for GMH-IVH.\n                  <\/jats:p>","DOI":"10.1177\/09636897261443446","type":"journal-article","created":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T12:49:25Z","timestamp":1778935765000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Downregulating ROCK2 by human umbilical cord mesenchymal stem cells promotes pro-resolving microglial polarization and alleviates cerebral injury in germinal matrix hemorrhage"],"prefix":"10.1177","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-5480-6310","authenticated-orcid":false,"given":"Mengting","family":"Yang","sequence":"first","affiliation":[{"name":"School of Pediatrics, 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