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We herein observed 7 months and investigated the viable tumors formation, the survival rate, the distribution of the injected cells in different reproductive organs after intravenous (IV) injection of the human menstrual blood\u2013derived MSCs (LXT- and CDH-huMenSCs), and the human umbilical MSCs (huMSCs). The survival rate was not different among the huMenSCs, the huMSCs, and the negative control (IV injection of PBS) group. The longevities of the mice died within the observation period of the LXT and the huMSCs groups were significantly longer than that in the other groups; the positive control (IV injection of LLC (Lewis lung carcinoma cells)) group had the shortest longevity. The number of visible tumors in the huMenSCs, huMSCs, and the negative control group was lower than that in the positive control group. Human-sourced DNA was only detected in the ovaries of the huMSCs-injected mice. The histological morphology of the CDH- group had more normal follicles than that in other groups; the CDH- and the huMSCs group had more atretic follicles than that in other groups. In the huMenSCs and the huMSCs groups, the testis seminiferous tubules were fuller and more orderly arranged than the negative control group. The endometrial thickness of the LXT- group was thicker than that of the huMSCs- and the negative control groups, whereas the number of uterine glands was similar among all groups. The results suggested that IV administrations of xenogeneic huMenSCs and huMSCs in nude mice did not cause tumor formation. The injected huMenSCs from different donors functioned differentially on the mice\u2019s life-span, endometrial thickness, and the number of follicles.<\/jats:p>","DOI":"10.1177\/09636897261446726","type":"journal-article","created":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T11:31:25Z","timestamp":1780140685000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparative analysis of the bio-safety of HuMSCs and HuMenSCs in the nude mice and their impacts on reproductive organs\u2019 histological morphology"],"prefix":"10.1177","volume":"35","author":[{"given":"Zhaoyi","family":"Li","sequence":"first","affiliation":[{"name":"School of Pharmacy, Faculty of Medicine &amp; State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanxian","family":"Huang","sequence":"additional","affiliation":[{"name":"Fuyuan Bio-life Co., Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tai Ip","family":"Chan","sequence":"additional","affiliation":[{"name":"Kiang Wu Hospital, Macau, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Xiao","sequence":"additional","affiliation":[{"name":"Kiang Wu Hospital, Macau, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8487-6568","authenticated-orcid":false,"given":"Yibing","family":"Han","sequence":"additional","affiliation":[{"name":"Laboratory of Drug Discovery from Natural Resources and Industrialization, School of Pharmacy, Macau University of Science and Technology, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi Zhun","family":"Zhu","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Faculty of Medicine &amp; State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, China"},{"name":"Laboratory of Drug Discovery from Natural Resources and Industrialization, School of Pharmacy, Macau University of Science and Technology, China"},{"name":"Shanghai Key Laboratory of Bioactive Small Molecules, Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,5,30]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2021.05.012"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2025.1623959"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-018-1105-9"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-019-1503-7"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/stem.3016"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/52.3.921"},{"key":"e_1_3_3_8_2","first-page":"247","article-title":"Observations on the immunobiology of \u2018nude\u2019 mice","volume":"20","author":"Pantelouris E","year":"1971","unstructured":"Pantelouris E. 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