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Umbilical cord\u2013derived mesenchymal stem cells (UC-MSCs) may support liver repair, but their delivery via the hepatic artery has not been evaluated. This study assessed the safety and exploratory efficacy of allogeneic UC-MSCs infusion in cirrhosis. Twenty patients with liver cirrhosis entered a single-center open-label pilot trial in Hanoi, Vietnam, between 2020 and 2023; 17 completed follow-up and were included in exploratory analyses. All received a single hepatic artery infusion of UC-MSCs at 1 \u00d7 10\n                    <jats:sup>6<\/jats:sup>\n                    cells\/kg and were assessed at baseline, 3, 6, and 12 months for liver function, Model for End-stage Liver Disease (MELD) and Child\u2013Pugh scores, Chronic Liver Disease Questionnaire (CLDQ), and adverse events. No serious adverse events occurred; mild events were self-limited. Albumin increased at 3 and 6 months (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.048;\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.027). Bilirubin, liver enzymes, coagulation, and MELD remained stable. Child\u2013Pugh score decreased transiently at 3 months (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.024). CLDQ increased across most domains, except systemic symptoms. Hepatic artery infusion of UC-MSCs was safe and well tolerated, with observed increases in albumin and in most CLDQ domains, while other parameters remained stable. Findings are exploratory because of the small sample size and lack of a control group and therefore require confirmation in larger, controlled studies.\n                  <\/jats:p>","DOI":"10.1177\/09636897261449975","type":"journal-article","created":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T10:27:26Z","timestamp":1779791246000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Safety and preliminary efficacy of allogeneic umbilical cord\u2013derived mesenchymal stem cells administered via the hepatic artery in patients with liver cirrhosis: A phase I open-label trial"],"prefix":"10.1177","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-5553-2164","authenticated-orcid":false,"given":"Liem Thanh","family":"Nguyen","sequence":"first","affiliation":[{"name":"Vinmec Research Institute of Stem Cell and Gene Technology (VRISG), College of Health Sciences, VinUniversity, Hanoi, Vietnam"},{"name":"Vinmec Times City International Hospital, Vinmec Healthcare System, Hanoi, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9544-5835","authenticated-orcid":false,"given":"Hoang-Phuong","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Vinmec Research Institute of Stem Cell and Gene Technology (VRISG), College of Health Sciences, VinUniversity, Hanoi, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang Thi","family":"Bui","sequence":"additional","affiliation":[{"name":"Vinmec Times City International Hospital, Vinmec Healthcare System, Hanoi, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quyen Thi","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Vinmec Research Institute of Stem Cell and Gene Technology (VRISG), College of Health Sciences, VinUniversity, Hanoi, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4592-340X","authenticated-orcid":false,"given":"Phan Van","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Vinmec Times City International Hospital, Vinmec Healthcare System, Hanoi, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hien Thi Thu","family":"Ha","sequence":"additional","affiliation":[{"name":"Vinmec Times City International Hospital, Vinmec Healthcare System, Hanoi, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,5,26]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/HC9.0000000000000026"},{"issue":"6","key":"e_1_3_3_3_2","first-page":"85","article-title":"The etiology, diagnosis and prevention of liver cirrhosis: part 1 of a series on liver cirrhosis","volume":"110","author":"Wiegand J","year":"2013","unstructured":"Wiegand J, Berg T. 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