{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T14:08:08Z","timestamp":1780582088331,"version":"3.54.1"},"reference-count":32,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Clinical Research Incubation Project"},{"DOI":"10.13039\/501100013365","name":"West China Hospital, Sichuan University","doi-asserted-by":"crossref","award":["2022HXFH031"],"award-info":[{"award-number":["2022HXFH031"]}],"id":[{"id":"10.13039\/501100013365","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cell Transplant"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:p>\n                    Although post-transplant cyclophosphamide (PTCy) is widely used to prevent graft-versus-host disease (GVHD), its protective effect remains inadequate in patients undergoing myeloablative haploidentical peripheral blood stem cell transplantation (haplo-PBSCT). We retrospectively evaluated the efficacy of PTCy combined with either pre-transplant or post-transplant antithymocyte globulin (ATG) for GVHD prevention in 114 haplo-PBSCT recipients. The PTCy+FTATG group (n = 74) received ATG at a total dose of 5 mg\/kg on days \u22123 to \u22121, together with PTCy at 25 mg\/kg on days +3 and +4. The PTCy+PTATG group (n = 40) received PTCy at 50 mg\/kg on days +3 and +4, followed by ATG at 2.5 mg\/kg on day +8. Both univariate and multivariate analyses showed that PTCy+FTATG prophylaxis significantly lowered the risk of grade II\u2013IV acute GVHD (9.5% vs 27.5% [HR 0.24; 95% CI: 0.10\u20130.59;\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.002]) and grade III\u2013IV acute GVHD (5.4% vs 17.5% [HR 0.19; 95% CI: 0.07\u20130.54;\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.002]). The 2-year cumulative incidence of chronic GVHD was 16.7% in the PTCy+FTATG group and 27.5% in the PTCy+PTATG group (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.15). At 2 years, overall survival (OS), progression-free survival (PFS), and graft-versus-host disease-free relapse-free survival (GRFS) were 87.8% vs 72.5% (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.04), 82.2% vs 65.0% (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.03), and 78.1% vs 55.0% (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.005), respectively. These results suggest that half-dose PTCy combined with low-dose pre-transplant ATG may be a promising strategy for GVHD prophylaxis.\n                  <\/jats:p>","DOI":"10.1177\/09636897261454024","type":"journal-article","created":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T11:03:22Z","timestamp":1780311802000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of the efficacy of pre-transplant and post-transplant antithymocyte globulin combined with post-transplant cyclophosphamide for graft-\n                    <i>versus<\/i>\n                    -host disease prophylaxis in myeloablative haploidentical peripheral blood stem cell transplantation"],"prefix":"10.1177","volume":"35","author":[{"given":"Xuelian","family":"Jin","sequence":"first","affiliation":[{"name":"Department of Hematology, West China Hospital, Sichuan University, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Hematology, West China Hospital, Sichuan University, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Hematology, West China Hospital, Sichuan University, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhigang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Hematology, West China Hospital, Sichuan University, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pu","family":"Kuang","sequence":"additional","affiliation":[{"name":"Department of Hematology, West China Hospital, Sichuan University, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hematology, West China Hospital, Sichuan University, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Hematology, West China Hospital, Sichuan University, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Hematology, West China Hospital, Sichuan University, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zerong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematology, West China Hospital, Sichuan University, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajia","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Hematology, West China Hospital, Sichuan University, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zilin","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Hematology, West China Hospital, Sichuan University, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9292-9623","authenticated-orcid":false,"given":"Xinchuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Hematology, West China Hospital, Sichuan University, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,6,1]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.72.8428"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2012.06.019"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2015.03.003"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2020.05.001"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-020-00882-6"},{"key":"e_1_3_3_7_2","article-title":"G-CSF-primed peripheral blood stem cell haploidentical transplantation could achieve satisfactory clinical outcomes for acute leukemia patients in the first complete remission: a registered study","volume":"11","author":"Ma YR","year":"2021","unstructured":"Ma YR, Zhang X, Xu L, Wang Y, Yan C, Chen H, Chen Y, Han W, Wang F, Wang J, et al. G-CSF-primed peripheral blood stem cell haploidentical transplantation could achieve satisfactory clinical outcomes for acute leukemia patients in the first complete remission: a registered study. Front Oncol. 2021;11:631625.","journal-title":"Front Oncol"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.980464"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.70050"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-019-0726-7"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2018.07.008"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-024-02216-3"},{"key":"e_1_3_3_13_2","article-title":"Low-dose anti-thymocyte globulin plus low-dose post-transplant cyclophosphamide-based regimen for prevention of graft-versus-host disease after haploidentical peripheral blood stem cell transplants: a large sample, long-term follow-up retrospective study","volume":"14","author":"Li X","year":"2023","unstructured":"Li X, Yang J, Cai Y, Huang C, Xu X, Qiu H, Niu J, Zhou K, Zhang Y, Xia X, et al. Low-dose anti-thymocyte globulin plus low-dose post-transplant cyclophosphamide-based regimen for prevention of graft-versus-host disease after haploidentical peripheral blood stem cell transplants: a large sample, long-term follow-up retrospective study. Front Immunol. 2023;14: 1252879.","journal-title":"Front Immunol"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1177\/20406207251353011"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.5966\/sctm.2012-0115"},{"issue":"3","key":"e_1_3_3_16_2","article-title":"Chronic cutaneous graft-versus-host disease in man","volume":"91","author":"Shulman HM","year":"1978","unstructured":"Shulman HM, Sale GE, Lerner KG, Barker EA, Weiden PL, Sullivan K, Gallucci B, Thomas ED, Storb R. Chronic cutaneous graft-versus-host disease in man. Am J Pathol. 1978; 91(3): 545\u201370.","journal-title":"Am J Pathol"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-016-2654-6"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI124218"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.16189"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-015-0186-5"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-023-05206-5"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020003005"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2018.12.142"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/tid.12455"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-015-2423-y"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2012.07.003"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtct.2024.07.017"},{"issue":"12","key":"e_1_3_3_28_2","article-title":"Lower incidence of cytomegalovirus reactivation following post-transplantation cyclophosphamide HLA-mismatched unrelated donor transplantation","volume":"27","author":"Camargo JF","year":"2021","unstructured":"Camargo JF, Ebisu Y, Jimenez-Jimenez A, Natori Y, Moroz I, Morris MI, Alencar M, Anderson AD, Lekakis L, Beitinjaneh A, et al. Lower incidence of cytomegalovirus reactivation following post-transplantation cyclophosphamide HLA-mismatched unrelated donor transplantation. 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