{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T17:31:47Z","timestamp":1792171907922,"version":"4.4.0"},"reference-count":83,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"General Project of Science and Technology Development Fund of Nanjing Medical University","award":["NMUB20240092"],"award-info":[{"award-number":["NMUB20240092"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cell Transplant"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Androgenic alopecia (AGA) is a common hair follicle miniaturization disease driven by androgens. Fibroblasts, especially dermal papilla (DP) cells, are considered the core of the pathogenesis of AGA, but there is a lack of systematic synthesis of evidence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To systematically review the role of fibroblasts (DP cells and dermal sheath cells) in the pathogenesis of AGA, with a focus on androgen signaling transduction, paracrine signaling, disruption of stem cell niche, inflammation, and fibrosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data sources<\/jats:title>\n                    <jats:p>PubMed and Web of Science, covering the period from August 23, 2025 to May 28, 2026, including human basic research, animal model studies, and clinical pathology studies related to AGA fibroblast function. Two reviewers independently screened literature, extracted data, and evaluated the risk of bias.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Result<\/jats:title>\n                    <jats:p>Through retrieval, a total of 1592 articles were identified, and 43 articles were ultimately included. DP cells consistently express high levels of androgen receptor (AR) and 5\u03b1-reductase type II. Activation of androgens (dihydrotestosterone) in DP cells leads to: (1) downregulation of Wnt\/\u03b2-catenin signaling and upregulation of TGF-\u03b2\/BMP pathway; (2) Changes in secretion profile (decrease in VEGF\/IGF-1 and increase in DKK-1\/TGF-\u03b21); (3) DP cell aggregation behavior is impaired; (4) Destruction of hair follicle stem cell activation; (5) Inducing inflammation and fibrosis around hair follicles. The evidence for dermal sheath cells as a DP cell bank is still limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>DP cells are the main transducers of androgen signaling in AGA, driving follicle miniaturization through multiple interrelated mechanisms. The current evidence supports DP cell dysfunction as a therapeutic strategy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/09636897261468231","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T12:24:47Z","timestamp":1783945487000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["The central role of fibroblasts in androgenic alopecia: A systematic umbrella review"],"prefix":"10.1177","volume":"35","author":[{"given":"Shanshan","family":"Yu","sequence":"first","affiliation":[{"name":"Women\u2019s Hospital of Nanjing Medical University (Nanjing Women and Children\u2019s Healthcare Hospital)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Ji","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Nanjing Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2493-3718","authenticated-orcid":false,"given":"Yingying","family":"Wu","sequence":"additional","affiliation":[{"name":"Women\u2019s Hospital of Nanjing Medical University (Nanjing Women and Children\u2019s Healthcare Hospital)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyun","family":"Li","sequence":"additional","affiliation":[{"name":"Women\u2019s Hospital of Nanjing Medical University (Nanjing Women and Children\u2019s Healthcare Hospital)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Yan","sequence":"additional","affiliation":[{"name":"Women\u2019s Hospital of Nanjing Medical University (Nanjing Women and Children\u2019s Healthcare Hospital)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongfang","family":"Xu","sequence":"additional","affiliation":[{"name":"Women\u2019s Hospital of Nanjing Medical University (Nanjing Women and Children\u2019s Healthcare Hospital)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutong","family":"Shi","sequence":"additional","affiliation":[{"name":"Women\u2019s Hospital of Nanjing Medical University (Nanjing Women and Children\u2019s Healthcare Hospital)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Li","sequence":"additional","affiliation":[{"name":"Women\u2019s Hospital of Nanjing Medical University (Nanjing Women and Children\u2019s Healthcare Hospital)"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,7,13]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.4103\/npmj.npmj_47_24"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-017-1280-y"},{"key":"e_1_3_7_4_2","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2022.2109567"},{"key":"e_1_3_7_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-019-00479-x"},{"key":"e_1_3_7_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.70167"},{"key":"e_1_3_7_7_2","doi-asserted-by":"publisher","DOI":"10.1080\/13548506.2023.2242049"},{"key":"e_1_3_7_8_2","doi-asserted-by":"publisher","DOI":"10.4103\/jfmpc.jfmpc_1151_23"},{"key":"e_1_3_7_9_2","doi-asserted-by":"publisher","DOI":"10.1055\/a-2196-4713"},{"key":"e_1_3_7_10_2","doi-asserted-by":"publisher","DOI":"10.1684\/ejd.2025.4815"},{"key":"e_1_3_7_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/dth.13202"},{"key":"e_1_3_7_12_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12030893"},{"key":"e_1_3_7_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.abd.2022.09.006"},{"key":"e_1_3_7_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.136.2.205"},{"key":"e_1_3_7_15_2","first-page":"112","article-title":"Bioinspired engineering ADSC nanovesicles thermosensitive hydrogel enhance autophagy of dermal papilla cells for androgenetic alopecia treatment","volume":"36","author":"Xiong J","year":"2024","unstructured":"Xiong J, Liu Z, Jia L, et al. Bioinspired engineering ADSC nanovesicles thermosensitive hydrogel enhance autophagy of dermal papilla cells for androgenetic alopecia treatment. Bioact Mater 2024; 36: 112\u2013125. https:\/\/doi.org\/10.1016\/j.bioactmat.2024.02.023","journal-title":"Bioact Mater"},{"key":"e_1_3_7_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-020-00441-y"},{"key":"e_1_3_7_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.111100"},{"key":"e_1_3_7_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2024.05.006"},{"key":"e_1_3_7_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-022-03730-w"},{"key":"e_1_3_7_20_2","doi-asserted-by":"publisher","DOI":"10.1159\/000510152"},{"key":"e_1_3_7_21_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms231911904"},{"key":"e_1_3_7_22_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules29102288"},{"key":"e_1_3_7_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.1995.32"},{"key":"e_1_3_7_24_2","doi-asserted-by":"publisher","DOI":"10.7150\/thno.39566"},{"key":"e_1_3_7_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/ced.12888"},{"key":"e_1_3_7_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12335779"},{"key":"e_1_3_7_27_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2826.2001.00635.x"},{"key":"e_1_3_7_28_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1999.03156.x"},{"key":"e_1_3_7_29_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2007.050906"},{"key":"e_1_3_7_30_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28145517"},{"key":"e_1_3_7_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-08968-2"},{"issue":"2","key":"e_1_3_7_32_2","first-page":"222","article-title":"Progenitor-derived endothelin controls dermal sheath contraction for hair follicle regression","volume":"25","author":"Martino P","year":"2023","unstructured":"Martino P, Sunkara R, Heitman N, et al. Progenitor-derived endothelin controls dermal sheath contraction for hair follicle regression. Nat Cell Biol 2023; 25(2): 222\u2013234. https:\/\/doi.org\/10.1038\/s41556-022-01065-w","journal-title":"Nat Cell Biol"},{"key":"e_1_3_7_33_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12015-022-10411-2"},{"key":"e_1_3_7_34_2","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.b24-00302"},{"key":"e_1_3_7_35_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26010095"},{"key":"e_1_3_7_36_2","doi-asserted-by":"publisher","DOI":"10.1111\/exd.14948"},{"key":"e_1_3_7_37_2","doi-asserted-by":"publisher","DOI":"10.1111\/exd.14204"},{"key":"e_1_3_7_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2022.06.005"},{"key":"e_1_3_7_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature12783"},{"key":"e_1_3_7_40_2","doi-asserted-by":"publisher","DOI":"10.1111\/ics.12489"},{"key":"e_1_3_7_41_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23168959"},{"issue":"2","key":"e_1_3_7_42_2","first-page":"195","article-title":"Adenosine stimulates growth of dermal papilla and lengthens the anagen phase by increasing the cysteine level via fibroblast growth factors 2 and 7 in an organ culture of mouse vibrissae hair follicles","volume":"29","author":"Hwang KA","year":"2012","unstructured":"Hwang KA, Hwang YL, Lee MH, et al. Adenosine stimulates growth of dermal papilla and lengthens the anagen phase by increasing the cysteine level via fibroblast growth factors 2 and 7 in an organ culture of mouse vibrissae hair follicles. Int J Mol Med 2012; 29(2): 195\u2013201. https:\/\/doi.org\/10.3892\/ijmm.2011.817","journal-title":"Int J Mol Med"},{"key":"e_1_3_7_43_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-013-1745-0"},{"key":"e_1_3_7_44_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.724310"},{"key":"e_1_3_7_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2022.11.004"},{"key":"e_1_3_7_46_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells12121645"},{"key":"e_1_3_7_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.139292"},{"key":"e_1_3_7_48_2","doi-asserted-by":"publisher","DOI":"10.1002\/cbin.70045"},{"key":"e_1_3_7_49_2","doi-asserted-by":"publisher","DOI":"10.24272\/j.issn.2095-8137.2025.034"},{"key":"e_1_3_7_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.reth.2022.10.005"},{"key":"e_1_3_7_51_2","doi-asserted-by":"publisher","DOI":"10.21873\/invivo.11592"},{"issue":"2","key":"e_1_3_7_52_2","first-page":"220","article-title":"Endothelin signalling drives dermal sheath smooth muscle contraction for hair follicle regression","volume":"25","year":"2023","unstructured":"Endothelin signalling drives dermal sheath smooth muscle contraction for hair follicle regression. Nat Cell Biol, 2023. 25(2): p. 220\u2013221.","journal-title":"Nat Cell Biol"},{"key":"e_1_3_7_53_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.116.3.563"},{"key":"e_1_3_7_54_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.114.4.887"},{"key":"e_1_3_7_55_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-0716-4510-9_5"},{"key":"e_1_3_7_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2016.02.002"},{"key":"e_1_3_7_57_2","doi-asserted-by":"publisher","DOI":"10.5070\/D36GZ420MW"},{"key":"e_1_3_7_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-202X(93)90513-H"},{"key":"e_1_3_7_59_2","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.80481"},{"key":"e_1_3_7_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.111247"},{"key":"e_1_3_7_61_2","doi-asserted-by":"publisher","DOI":"10.1080\/14728214.2024.2346590"},{"key":"e_1_3_7_62_2","doi-asserted-by":"publisher","DOI":"10.1159\/000525067"},{"key":"e_1_3_7_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2025.02.029"},{"key":"e_1_3_7_64_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21155342"},{"key":"e_1_3_7_65_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12462307"},{"key":"e_1_3_7_66_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27196443"},{"key":"e_1_3_7_67_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-023-03398-1"},{"key":"e_1_3_7_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/bs.vh.2023.01.001"},{"key":"e_1_3_7_69_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1007024726889"},{"key":"e_1_3_7_70_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21144915"},{"key":"e_1_3_7_71_2","doi-asserted-by":"publisher","DOI":"10.1111\/bph.15438"},{"key":"e_1_3_7_72_2","doi-asserted-by":"publisher","DOI":"10.1155\/2023\/5548112"},{"key":"e_1_3_7_73_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.115913"},{"key":"e_1_3_7_74_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.02-0043fje"},{"key":"e_1_3_7_75_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells8050466"},{"key":"e_1_3_7_76_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2025.03.042"},{"key":"e_1_3_7_77_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-023-00662-3"},{"key":"e_1_3_7_78_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-021-02527-y"},{"key":"e_1_3_7_79_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.09.059"},{"key":"e_1_3_7_80_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2019.12.056"},{"key":"e_1_3_7_81_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.22377"},{"key":"e_1_3_7_82_2","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2017.6779"},{"issue":"6","key":"e_1_3_7_83_2","first-page":"1785","article-title":"Cell Therapy for Androgenetic Alopecia: Elixir or Trick? Stem","volume":"19","author":"Mao Y","year":"2023","unstructured":"Mao Y, Liu P, Wei J, et al. Cell Therapy for Androgenetic Alopecia: Elixir or Trick? Stem. Cell Rev Rep 2023; 19(6): 1785\u20131799. https:\/\/doi.org\/10.1007\/s12015-023-10532-2","journal-title":"Cell Rev Rep"},{"key":"e_1_3_7_84_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00266-025-04817-9"}],"container-title":["Cell Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09636897261468231","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/09636897261468231","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/09636897261468231","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T06:48:23Z","timestamp":1784184503000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/09636897261468231"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":83,"alternative-id":["10.1177\/09636897261468231"],"URL":"https:\/\/doi.org\/10.1177\/09636897261468231","relation":{},"ISSN":["0963-6897","1555-3892"],"issn-type":[{"value":"0963-6897","type":"print"},{"value":"1555-3892","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"article-number":"09636897261468231"}}