{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T04:05:56Z","timestamp":1784261156750,"version":"3.55.0"},"reference-count":22,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Clinical Medical Research Center Project of Xi\u2019an Jiaotong University"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cell Transplant"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:p>To investigate the efficacy and safety of MTBF as conditioning regimen for salvage allogeneic hematopoietic stem cell transplantation (allo-HSCT) in patients with relapsed or refractory acute myeloid leukemia (R\/R AML). We conducted a single-arm prospective clinical trial (NCT06385808). The main outcome was cumulative incidence of relapse (CIR), and the secondary outcomes were progression-free survival (PFS), overall survival (OS), engraftment time, graft-versus-host disease (GVHD), and non-hematological adverse effects. Twenty-four R\/R AML patients from the First Affiliated Hospital of Xi\u2019an Jiaotong University were enrolled, and all achieved engraftment. Mucositis was the predominant toxicity and was managed appropriately. The two-year CIR was 10%. The two-year OS and PFS were 78.9 \u00b1 11.1% and 51.2 \u00b1 19.3%, respectively. Two patients experienced relapse, and three patients died of infection. Subgroup analyses demonstrated that maintenance treatment post-transplantation may improve OS. The MTBF regimen for salvage allo-HSCT in R\/R AML exhibited notable anti-leukemia activity and tolerable toxicity. (NCT06385808, Efficacy and Safety of\u2002MTBF\u2002Conditioning Regimen for Salvageable Allo-HSCT in the Treatment of R\/R AML).<\/jats:p>","DOI":"10.1177\/09636897261469013","type":"journal-article","created":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T12:10:54Z","timestamp":1784031054000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy and safety of mitoxantrone hydrochloride liposome\/ thiotepa\/ busulfan\/fludarabine (MTBF) conditioning regimen for salvage allogeneic hematopoietic stem cell transplantation in patients with relapsed or refractory acute myeloid leukemia: A single - Arm prospective clinical trial"],"prefix":"10.1177","volume":"35","author":[{"given":"Juan","family":"Ren","sequence":"first","affiliation":[{"name":"The First Affiliated Hospital of Xi\u2019an Jiaotong University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tongxin","family":"Zhang","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Xi\u2019an Jiaotong University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqi","family":"Wang","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Xi\u2019an Jiaotong University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huachao","family":"Zhu","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Xi\u2019an Jiaotong University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruimin","family":"Liu","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Xi\u2019an Jiaotong University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengcheng","family":"He","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Xi\u2019an Jiaotong University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2472-4076","authenticated-orcid":false,"given":"Xiaoning","family":"Wang","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Xi\u2019an Jiaotong University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,7,14]]},"reference":[{"key":"e_1_3_8_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/joim.70004"},{"key":"e_1_3_8_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/HS9.0000000000000952"},{"key":"e_1_3_8_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-019-0727-4"},{"key":"e_1_3_8_5_2","doi-asserted-by":"publisher","DOI":"10.7150\/jca.105557"},{"issue":"2","key":"e_1_3_8_6_2","first-page":"365","article-title":"[Clinical Analysis of Mitoxantrone Liposome in the Treatment of Children with High-Risk Acute Myeloid Leukemia]","volume":"32","author":"Jiao YQ","year":"2024","unstructured":"Jiao YQ, Xiong H, Chen Z, et al. [Clinical Analysis of Mitoxantrone Liposome in the Treatment of Children with High-Risk Acute Myeloid Leukemia]. Zhongguo Shi Yan Xue Ye Xue Za Zhi 2024; 32(2): 365\u2013369.","journal-title":"Zhongguo Shi Yan Xue Ye Xue Za Zhi"},{"key":"e_1_3_8_7_2","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2025017116"},{"key":"e_1_3_8_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtct.2025.05.016"},{"key":"e_1_3_8_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2025.04.001"},{"issue":"2","key":"e_1_3_8_10_2","first-page":"179","article-title":"[Progress in hematopoietic stem cell transplantation for acute myeloid leukemia]","volume":"46","author":"Zhu XL","year":"2025","unstructured":"Zhu XL, Huang XJ, Wang Y. [Progress in hematopoietic stem cell transplantation for acute myeloid leukemia]. Zhonghua Xue Ye Xue Za Zhi 2025; 46(2): 179\u2013185.","journal-title":"Zhonghua Xue Ye Xue Za Zhi"},{"key":"e_1_3_8_11_2","first-page":"S0041","article-title":"The Application of Personalized Conditioning Regimens in Relapsed\/Refractory Acute Myeloid Leukemia Receiving Allogeneic Hematopoietic Stem Cell Transplantation","volume":"13","author":"Liu S","year":"2025","unstructured":"Liu S, Zhou B, Qian C, et al. The Application of Personalized Conditioning Regimens in Relapsed\/Refractory Acute Myeloid Leukemia Receiving Allogeneic Hematopoietic Stem Cell Transplantation. 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